A nutrient sensor mechanism controls Drosophila growth

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

A nutrient sensor mechanism controls Drosophila growth. / Colombani, Julien; Raisin, Sophie; Pantalacci, Sophie; Radimerski, Thomas; Montagne, Jacques; Léopold, Pierre.

In: Cell, Vol. 114, No. 6, 19.09.2003, p. 739-49.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Colombani, J, Raisin, S, Pantalacci, S, Radimerski, T, Montagne, J & Léopold, P 2003, 'A nutrient sensor mechanism controls Drosophila growth', Cell, vol. 114, no. 6, pp. 739-49.

APA

Colombani, J., Raisin, S., Pantalacci, S., Radimerski, T., Montagne, J., & Léopold, P. (2003). A nutrient sensor mechanism controls Drosophila growth. Cell, 114(6), 739-49.

Vancouver

Colombani J, Raisin S, Pantalacci S, Radimerski T, Montagne J, Léopold P. A nutrient sensor mechanism controls Drosophila growth. Cell. 2003 Sep 19;114(6):739-49.

Author

Colombani, Julien ; Raisin, Sophie ; Pantalacci, Sophie ; Radimerski, Thomas ; Montagne, Jacques ; Léopold, Pierre. / A nutrient sensor mechanism controls Drosophila growth. In: Cell. 2003 ; Vol. 114, No. 6. pp. 739-49.

Bibtex

@article{f2b1afd5d9c949ac8016183bd4de819c,
title = "A nutrient sensor mechanism controls Drosophila growth",
abstract = "Organisms modulate their growth according to nutrient availability. Although individual cells in a multicellular animal may respond directly to nutrient levels, growth of the entire organism needs to be coordinated. Here, we provide evidence that in Drosophila, coordination of organismal growth originates from the fat body, an insect organ that retains endocrine and storage functions of the vertebrate liver. In a genetic screen for growth modifiers, we identified slimfast, a gene that encodes an amino acid transporter. Remarkably, downregulation of slimfast specifically within the fat body causes a global growth defect similar to that seen in Drosophila raised under poor nutritional conditions. This involves TSC/TOR signaling in the fat body, and a remote inhibition of organismal growth via local repression of PI3-kinase signaling in peripheral tissues. Our results demonstrate that the fat body functions as a nutrient sensor that restricts global growth through a humoral mechanism.",
keywords = "Amino Acid Transport Systems/deficiency, Amino Acids/deficiency, Animals, Down-Regulation/physiology, Drosophila Proteins/deficiency, Drosophila melanogaster/cytology, Fat Body/metabolism, Feedback, Physiological/genetics, Food Deprivation/physiology, Gene Expression Regulation, Developmental/genetics, Juvenile Hormones/deficiency, Nutritional Physiological Phenomena/physiology, Phosphatidylinositol 3-Kinases/metabolism, Receptor Protein-Tyrosine Kinases/metabolism, Signal Transduction/physiology",
author = "Julien Colombani and Sophie Raisin and Sophie Pantalacci and Thomas Radimerski and Jacques Montagne and Pierre L{\'e}opold",
year = "2003",
month = sep,
day = "19",
language = "English",
volume = "114",
pages = "739--49",
journal = "Cell",
issn = "0092-8674",
publisher = "Cell Press",
number = "6",

}

RIS

TY - JOUR

T1 - A nutrient sensor mechanism controls Drosophila growth

AU - Colombani, Julien

AU - Raisin, Sophie

AU - Pantalacci, Sophie

AU - Radimerski, Thomas

AU - Montagne, Jacques

AU - Léopold, Pierre

PY - 2003/9/19

Y1 - 2003/9/19

N2 - Organisms modulate their growth according to nutrient availability. Although individual cells in a multicellular animal may respond directly to nutrient levels, growth of the entire organism needs to be coordinated. Here, we provide evidence that in Drosophila, coordination of organismal growth originates from the fat body, an insect organ that retains endocrine and storage functions of the vertebrate liver. In a genetic screen for growth modifiers, we identified slimfast, a gene that encodes an amino acid transporter. Remarkably, downregulation of slimfast specifically within the fat body causes a global growth defect similar to that seen in Drosophila raised under poor nutritional conditions. This involves TSC/TOR signaling in the fat body, and a remote inhibition of organismal growth via local repression of PI3-kinase signaling in peripheral tissues. Our results demonstrate that the fat body functions as a nutrient sensor that restricts global growth through a humoral mechanism.

AB - Organisms modulate their growth according to nutrient availability. Although individual cells in a multicellular animal may respond directly to nutrient levels, growth of the entire organism needs to be coordinated. Here, we provide evidence that in Drosophila, coordination of organismal growth originates from the fat body, an insect organ that retains endocrine and storage functions of the vertebrate liver. In a genetic screen for growth modifiers, we identified slimfast, a gene that encodes an amino acid transporter. Remarkably, downregulation of slimfast specifically within the fat body causes a global growth defect similar to that seen in Drosophila raised under poor nutritional conditions. This involves TSC/TOR signaling in the fat body, and a remote inhibition of organismal growth via local repression of PI3-kinase signaling in peripheral tissues. Our results demonstrate that the fat body functions as a nutrient sensor that restricts global growth through a humoral mechanism.

KW - Amino Acid Transport Systems/deficiency

KW - Amino Acids/deficiency

KW - Animals

KW - Down-Regulation/physiology

KW - Drosophila Proteins/deficiency

KW - Drosophila melanogaster/cytology

KW - Fat Body/metabolism

KW - Feedback, Physiological/genetics

KW - Food Deprivation/physiology

KW - Gene Expression Regulation, Developmental/genetics

KW - Juvenile Hormones/deficiency

KW - Nutritional Physiological Phenomena/physiology

KW - Phosphatidylinositol 3-Kinases/metabolism

KW - Receptor Protein-Tyrosine Kinases/metabolism

KW - Signal Transduction/physiology

M3 - Journal article

C2 - 14505573

VL - 114

SP - 739

EP - 749

JO - Cell

JF - Cell

SN - 0092-8674

IS - 6

ER -

ID: 213244238