A novel treatment for weight reduction by the recombinant "Pichia pastoris" yeast expressing the hybrid protein of "irisin-furin-transferrin"
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A novel treatment for weight reduction by the recombinant "Pichia pastoris" yeast expressing the hybrid protein of "irisin-furin-transferrin". / Jalili, Mahsa; Bazi, Zahra; Hekmatdoost, Azita.
In: Journal of Integrative Medicine, Vol. 14, No. 1, 2016, p. 1-4.Research output: Contribution to journal › Review › Research › peer-review
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TY - JOUR
T1 - A novel treatment for weight reduction by the recombinant "Pichia pastoris" yeast expressing the hybrid protein of "irisin-furin-transferrin"
AU - Jalili, Mahsa
AU - Bazi, Zahra
AU - Hekmatdoost, Azita
N1 - (Ekstern)
PY - 2016
Y1 - 2016
N2 - Obesity is a major health problem across the world, but there are few ways to effectively treat or manage it in the long term. Researchers are searching for more convenient, cost-effective and noninvasive therapies for overweight and obese people. Recent studies have illustrated that the microbiome of the body's different organs can be used as a vehicle for in-situ gene therapy. We suggest that the recombinant form of "Pichia pastoris" yeast expressing the hybrid protein of "irisin-furin-transferrin" under the control of the enolase 1 promoter is a new nutraceutical strategy to absorb fewer calories from intestinal nutrients, and induce a higher metabolic rate to expend more calories, similar to that from engaging in physical activity. By comparison, this method can be a long-term, noninvasive treatment and can be used for obese patients who have movement limitations.
AB - Obesity is a major health problem across the world, but there are few ways to effectively treat or manage it in the long term. Researchers are searching for more convenient, cost-effective and noninvasive therapies for overweight and obese people. Recent studies have illustrated that the microbiome of the body's different organs can be used as a vehicle for in-situ gene therapy. We suggest that the recombinant form of "Pichia pastoris" yeast expressing the hybrid protein of "irisin-furin-transferrin" under the control of the enolase 1 promoter is a new nutraceutical strategy to absorb fewer calories from intestinal nutrients, and induce a higher metabolic rate to expend more calories, similar to that from engaging in physical activity. By comparison, this method can be a long-term, noninvasive treatment and can be used for obese patients who have movement limitations.
KW - Biotechnology
KW - DNA, recombinant
KW - Nutrition
KW - Obesity
UR - http://www.scopus.com/inward/record.url?scp=85057497264&partnerID=8YFLogxK
U2 - 10.1016/S2095-4964(16)60242-X
DO - 10.1016/S2095-4964(16)60242-X
M3 - Review
C2 - 26778222
AN - SCOPUS:85057497264
VL - 14
SP - 1
EP - 4
JO - Journal of integrative medicine
JF - Journal of integrative medicine
SN - 2095-4964
IS - 1
ER -
ID: 248338664