A naturalistic study of plasma lipid alterations in female patients with anorexia nervosa before and after weight restoration treatment
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A naturalistic study of plasma lipid alterations in female patients with anorexia nervosa before and after weight restoration treatment. / Hussain, Alia Arif; Carlsson, Jessica; Mortensen, Erik Lykke; Hemmingsen, Simone Daugaard; Bulik, Cynthia M.; Støving, René Klinkby; Sjögren, Jan Magnus.
In: Journal of Eating Disorders, Vol. 12, No. 1, 92, 2024.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - A naturalistic study of plasma lipid alterations in female patients with anorexia nervosa before and after weight restoration treatment
AU - Hussain, Alia Arif
AU - Carlsson, Jessica
AU - Mortensen, Erik Lykke
AU - Hemmingsen, Simone Daugaard
AU - Bulik, Cynthia M.
AU - Støving, René Klinkby
AU - Sjögren, Jan Magnus
N1 - Publisher Copyright: © The Author(s) 2024.
PY - 2024
Y1 - 2024
N2 - Background: Plasma lipid concentrations in patients with anorexia nervosa (AN) seem to be altered. Methods: We conducted a naturalistic study with 75 adult female patients with AN and 26 healthy female controls (HC). We measured plasma lipid profile, sex hormones and used self-report questionnaires at admission and discharge. Results: Total cholesterol (median (IQR): 4.9 (1.2)) and triglycerides (TG) (1.2 (0.8)) were elevated in AN at admission (BMI 15.3 (3.4)) compared with HC (4.3 (0.7), p = 0.003 and 0.9 (0.3), p = 0.006) and remained elevated at discharge (BMI 18.9 (2.9)) after weight restoration treatment. Estradiol (0.05 (0.1)) and testosterone (0.5 (0.7)) were lower in AN compared with HC (0.3 (0.3), p = < 0.001 and 0.8 (0.5), p = 0.03) and remained low at discharge. There was no change in eating disorder symptoms. Depression symptoms decreased (33 (17) to 30.5 (19), (p = 0.007)). Regression analyses showed that illness duration was a predictor of TG, age was a predictor of total cholesterol and LDL, while educational attainment predicted LDL and TG. Conclusion: Lipid concentrations remained elevated following weight restoration treatment, suggesting an underlying, premorbid dysregulation in the lipid metabolism in AN that persists following weight restoration. Elevated lipid concentrations may be present prior to illness onset in AN. Level of evidence: III: Evidence obtained from well-designed cohort or case–control analytic studies.
AB - Background: Plasma lipid concentrations in patients with anorexia nervosa (AN) seem to be altered. Methods: We conducted a naturalistic study with 75 adult female patients with AN and 26 healthy female controls (HC). We measured plasma lipid profile, sex hormones and used self-report questionnaires at admission and discharge. Results: Total cholesterol (median (IQR): 4.9 (1.2)) and triglycerides (TG) (1.2 (0.8)) were elevated in AN at admission (BMI 15.3 (3.4)) compared with HC (4.3 (0.7), p = 0.003 and 0.9 (0.3), p = 0.006) and remained elevated at discharge (BMI 18.9 (2.9)) after weight restoration treatment. Estradiol (0.05 (0.1)) and testosterone (0.5 (0.7)) were lower in AN compared with HC (0.3 (0.3), p = < 0.001 and 0.8 (0.5), p = 0.03) and remained low at discharge. There was no change in eating disorder symptoms. Depression symptoms decreased (33 (17) to 30.5 (19), (p = 0.007)). Regression analyses showed that illness duration was a predictor of TG, age was a predictor of total cholesterol and LDL, while educational attainment predicted LDL and TG. Conclusion: Lipid concentrations remained elevated following weight restoration treatment, suggesting an underlying, premorbid dysregulation in the lipid metabolism in AN that persists following weight restoration. Elevated lipid concentrations may be present prior to illness onset in AN. Level of evidence: III: Evidence obtained from well-designed cohort or case–control analytic studies.
KW - Anorexia nervosa
KW - Cholesterol
KW - Eating disorders
KW - Estradiol
KW - Lipids
KW - Sex hormones
KW - Testosterone
U2 - 10.1186/s40337-024-01055-3
DO - 10.1186/s40337-024-01055-3
M3 - Journal article
C2 - 38956654
AN - SCOPUS:85197256717
VL - 12
JO - Journal of Eating Disorders
JF - Journal of Eating Disorders
SN - 2050-2974
IS - 1
M1 - 92
ER -
ID: 397714243