A nation-wide population-based longitudinal study mapping physical diseases in patients with bipolar disorder and their siblings
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A nation-wide population-based longitudinal study mapping physical diseases in patients with bipolar disorder and their siblings. / Kessing, Lars Vedel; Ziersen, Simon Christoffer; Andersen, Per Kragh; Vinberg, Maj.
In: Journal of Affective Disorders, Vol. 282, 2021, p. 18-25.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - A nation-wide population-based longitudinal study mapping physical diseases in patients with bipolar disorder and their siblings
AU - Kessing, Lars Vedel
AU - Ziersen, Simon Christoffer
AU - Andersen, Per Kragh
AU - Vinberg, Maj
PY - 2021
Y1 - 2021
N2 - Background: Patients with bipolar disorder may have increased risk of physical diseases due to genetic and environmental factors, but no study has systematically mapped all physical comorbidities in such subjects. The aim was to map rates of all physical diseases among patients and siblings to patients with bipolar disorder. Methods: We used Danish nation-wide population-based longitudinal register linkage to identify 19.955 patients with bipolar disorder, their 13.923 siblings and 20 sex, age and calendar matched control individuals from the general population. Follow-up was from 1995 to 2017. Results: Bipolar disorder was associated with increased rates of all physical disease categories compared with rates for control individuals, except for cancer. Further, bipolar disorder was associated with increased rates of separate disorders including ischemic heart disease, diabetes, dementia, hypertension, hypercholesterolemia and hyperlipidemia, hypothyroidism and infections. In contrast, siblings to patients with bipolar disorder who were unaffected by bipolar disorder had increased rates of certain disorders, only, comprising infectious and parasitic diseases, and diseases of the nervous system, digestive system and genitourinary system. Limitations: Underdetection of physical disorders is likely because data are not available for persons who do not seek help for their disorders. Conclusions: Bipolar disorder was associated with increased rates of all physical diseases categories, except cancer, and with separate disorders, likely involving inflammatory components in the pathogenesis. In contrast, unaffected siblings to patients with bipolar disorder had increased rates of certain disorders, only.
AB - Background: Patients with bipolar disorder may have increased risk of physical diseases due to genetic and environmental factors, but no study has systematically mapped all physical comorbidities in such subjects. The aim was to map rates of all physical diseases among patients and siblings to patients with bipolar disorder. Methods: We used Danish nation-wide population-based longitudinal register linkage to identify 19.955 patients with bipolar disorder, their 13.923 siblings and 20 sex, age and calendar matched control individuals from the general population. Follow-up was from 1995 to 2017. Results: Bipolar disorder was associated with increased rates of all physical disease categories compared with rates for control individuals, except for cancer. Further, bipolar disorder was associated with increased rates of separate disorders including ischemic heart disease, diabetes, dementia, hypertension, hypercholesterolemia and hyperlipidemia, hypothyroidism and infections. In contrast, siblings to patients with bipolar disorder who were unaffected by bipolar disorder had increased rates of certain disorders, only, comprising infectious and parasitic diseases, and diseases of the nervous system, digestive system and genitourinary system. Limitations: Underdetection of physical disorders is likely because data are not available for persons who do not seek help for their disorders. Conclusions: Bipolar disorder was associated with increased rates of all physical diseases categories, except cancer, and with separate disorders, likely involving inflammatory components in the pathogenesis. In contrast, unaffected siblings to patients with bipolar disorder had increased rates of certain disorders, only.
KW - Bipolar disorder
KW - Inflammation
KW - Physical diseases
KW - Siblings
U2 - 10.1016/j.jad.2020.12.072
DO - 10.1016/j.jad.2020.12.072
M3 - Journal article
C2 - 33387742
AN - SCOPUS:85098720104
VL - 282
SP - 18
EP - 25
JO - Journal of Affective Disorders
JF - Journal of Affective Disorders
SN - 0165-0327
ER -
ID: 258769881