A long-term follow-up study of the Hand Eczema Trial (HET): a randomized clinical trial of a secondary preventive programme introduced to Danish healthcare workers
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A long-term follow-up study of the Hand Eczema Trial (HET) : a randomized clinical trial of a secondary preventive programme introduced to Danish healthcare workers. / Graversgaard, Christine; Agner, Tove; Jemec, Gregor B. E.; Thomsen, Simon F.; Ibler, Kristina.
In: Contact Dermatitis, Vol. 78, No. 5, 05.2018, p. 329-334.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - A long-term follow-up study of the Hand Eczema Trial (HET)
T2 - a randomized clinical trial of a secondary preventive programme introduced to Danish healthcare workers
AU - Graversgaard, Christine
AU - Agner, Tove
AU - Jemec, Gregor B. E.
AU - Thomsen, Simon F.
AU - Ibler, Kristina
PY - 2018/5
Y1 - 2018/5
N2 - Background. Preventive skin care programmes have shown beneficial effects on the prevalence and severity of hand eczema, but most trials only report short-term outcomes. One such trial was the randomized Hand Eczema Trial (HET, 2009) investigating the effects of a secondary prevention programme in healthcare workers. Positive results have been reported at 5-month follow-up. Objectives. To examine the long-term (42-47 months) effects of the HET. Methods. The present study was a follow-up questionnaire study on the effect of the intervention. Outcomes were the presence and severity of hand eczema, health-related quality of life (HR-QoL), skin protective behaviour, and knowledge of skin protection. A supplementary outcome was general improvement/worsening of hand eczema. Results. Comparison of the outcomes at follow-up showed no marked differences between the two groups. General improvement was reported by 70% in the intervention group and by 54% in the control group (p=0.25). A small, statistically significant improvement was found regarding HR-QoL in the intervention group only (p=0.015). Conclusions. The impact of an intervention that is effective after 5 months is attenuated over time, with no long-term effect on the outcomes examined. We suggest that skin care education should be repeated at regular intervals
AB - Background. Preventive skin care programmes have shown beneficial effects on the prevalence and severity of hand eczema, but most trials only report short-term outcomes. One such trial was the randomized Hand Eczema Trial (HET, 2009) investigating the effects of a secondary prevention programme in healthcare workers. Positive results have been reported at 5-month follow-up. Objectives. To examine the long-term (42-47 months) effects of the HET. Methods. The present study was a follow-up questionnaire study on the effect of the intervention. Outcomes were the presence and severity of hand eczema, health-related quality of life (HR-QoL), skin protective behaviour, and knowledge of skin protection. A supplementary outcome was general improvement/worsening of hand eczema. Results. Comparison of the outcomes at follow-up showed no marked differences between the two groups. General improvement was reported by 70% in the intervention group and by 54% in the control group (p=0.25). A small, statistically significant improvement was found regarding HR-QoL in the intervention group only (p=0.015). Conclusions. The impact of an intervention that is effective after 5 months is attenuated over time, with no long-term effect on the outcomes examined. We suggest that skin care education should be repeated at regular intervals
KW - hand dermatitis
KW - hand eczema
KW - long-term follow-up
KW - occupational hand dermatitis
KW - occupational skin diasease
KW - prevention programme
KW - randomized clinical trial
KW - secondary prevention programme
U2 - 10.1111/cod.12964
DO - 10.1111/cod.12964
M3 - Journal article
VL - 78
SP - 329
EP - 334
JO - Contact Dermatitis
JF - Contact Dermatitis
SN - 0105-1873
IS - 5
ER -
ID: 215787623