Trying to remember: immunological B cell memory to malaria
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Trying to remember : immunological B cell memory to malaria. / Hviid, Lars; Barfod, Lea; Fowkes, Freya J I.
I: Trends in Parasitology, Bind 31, Nr. 3, 03.2015, s. 89-94.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - Trying to remember
T2 - immunological B cell memory to malaria
AU - Hviid, Lars
AU - Barfod, Lea
AU - Fowkes, Freya J I
N1 - Copyright © 2014 Elsevier Ltd. All rights reserved.
PY - 2015/3
Y1 - 2015/3
N2 - In areas with stable transmission of Plasmodium falciparum parasites, even partially-protective immunity to malaria is acquired only after years of exposure and several infections. It has long been speculated that malaria parasites are directly able to undermine the establishment and maintenance of immunological memory, and that the often transient antibody responses to this parasite are evidence of such a dysfunction. We propose that long-lived antibody responses may not always be a prerequisite for protection, and that antibody longevity varies in an exposure- and age-dependent manner.
AB - In areas with stable transmission of Plasmodium falciparum parasites, even partially-protective immunity to malaria is acquired only after years of exposure and several infections. It has long been speculated that malaria parasites are directly able to undermine the establishment and maintenance of immunological memory, and that the often transient antibody responses to this parasite are evidence of such a dysfunction. We propose that long-lived antibody responses may not always be a prerequisite for protection, and that antibody longevity varies in an exposure- and age-dependent manner.
U2 - 10.1016/j.pt.2014.12.009
DO - 10.1016/j.pt.2014.12.009
M3 - Review
C2 - 25596801
VL - 31
SP - 89
EP - 94
JO - Trends in Parasitology
JF - Trends in Parasitology
SN - 1471-4922
IS - 3
ER -
ID: 132650841