Regulation of ciliary membrane protein trafficking and signalling by kinesin motor proteins
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Regulation of ciliary membrane protein trafficking and signalling by kinesin motor proteins. / Morthorst, Stine Kjær; Christensen, Søren Tvorup; Pedersen, Lotte Bang.
I: F E B S Journal, Bind 285, Nr. 24, 2018, s. 4535-4564.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - Regulation of ciliary membrane protein trafficking and signalling by kinesin motor proteins
AU - Morthorst, Stine Kjær
AU - Christensen, Søren Tvorup
AU - Pedersen, Lotte Bang
N1 - This article is protected by copyright. All rights reserved.
PY - 2018
Y1 - 2018
N2 - Primary cilia are antenna-like sensory organelles that regulate a substantial number of cellular signalling pathways in vertebrates, both during embryonic development as well as in adulthood, and mutations in genes coding for ciliary proteins are causative of an expanding group of pleiotropic diseases known as ciliopathies. Cilia consist of a microtubule-based axoneme core, which is subtended by a basal body and covered by a bilayer lipid membrane of unique protein and lipid composition. Cilia are dynamic organelles, and the ability of cells to regulate ciliary protein and lipid content in response to specific cellular and environmental cues is crucial for balancing ciliary signalling output. Here we discuss mechanisms involved in regulation of ciliary membrane protein trafficking and signalling, with main focus on kinesin-2 and kinesin-3 family members. This article is protected by copyright. All rights reserved.
AB - Primary cilia are antenna-like sensory organelles that regulate a substantial number of cellular signalling pathways in vertebrates, both during embryonic development as well as in adulthood, and mutations in genes coding for ciliary proteins are causative of an expanding group of pleiotropic diseases known as ciliopathies. Cilia consist of a microtubule-based axoneme core, which is subtended by a basal body and covered by a bilayer lipid membrane of unique protein and lipid composition. Cilia are dynamic organelles, and the ability of cells to regulate ciliary protein and lipid content in response to specific cellular and environmental cues is crucial for balancing ciliary signalling output. Here we discuss mechanisms involved in regulation of ciliary membrane protein trafficking and signalling, with main focus on kinesin-2 and kinesin-3 family members. This article is protected by copyright. All rights reserved.
U2 - 10.1111/febs.14583
DO - 10.1111/febs.14583
M3 - Review
C2 - 29894023
VL - 285
SP - 4535
EP - 4564
JO - F E B S Journal
JF - F E B S Journal
SN - 1742-464X
IS - 24
ER -
ID: 197964239