Local administration of growth hormone stimulates tendon collagen synthesis in elderly men

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Standard

Local administration of growth hormone stimulates tendon collagen synthesis in elderly men. / Vestergaard, Poul Erik; Jørgensen, Jens Otto Lunde; Olesen, Jens; Bosnjak, Ermina; Holm, Lars; Frystyk, Jan; Langberg, Henning; Kjaer, Michael; Hansen, Mette Damborg.

I: Journal of Applied Physiology, Bind 113, Nr. 9, 11.2012, s. 1432-8.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Vestergaard, PE, Jørgensen, JOL, Olesen, J, Bosnjak, E, Holm, L, Frystyk, J, Langberg, H, Kjaer, M & Hansen, MD 2012, 'Local administration of growth hormone stimulates tendon collagen synthesis in elderly men', Journal of Applied Physiology, bind 113, nr. 9, s. 1432-8. https://doi.org/10.1152/japplphysiol.00816.2012

APA

Vestergaard, P. E., Jørgensen, J. O. L., Olesen, J., Bosnjak, E., Holm, L., Frystyk, J., Langberg, H., Kjaer, M., & Hansen, M. D. (2012). Local administration of growth hormone stimulates tendon collagen synthesis in elderly men. Journal of Applied Physiology, 113(9), 1432-8. https://doi.org/10.1152/japplphysiol.00816.2012

Vancouver

Vestergaard PE, Jørgensen JOL, Olesen J, Bosnjak E, Holm L, Frystyk J o.a. Local administration of growth hormone stimulates tendon collagen synthesis in elderly men. Journal of Applied Physiology. 2012 nov.;113(9):1432-8. https://doi.org/10.1152/japplphysiol.00816.2012

Author

Vestergaard, Poul Erik ; Jørgensen, Jens Otto Lunde ; Olesen, Jens ; Bosnjak, Ermina ; Holm, Lars ; Frystyk, Jan ; Langberg, Henning ; Kjaer, Michael ; Hansen, Mette Damborg. / Local administration of growth hormone stimulates tendon collagen synthesis in elderly men. I: Journal of Applied Physiology. 2012 ; Bind 113, Nr. 9. s. 1432-8.

Bibtex

@article{208024e458564c48b60bc83a85865b55,
title = "Local administration of growth hormone stimulates tendon collagen synthesis in elderly men",
abstract = "Tendon collagen content and circulating growth hormone (GH) are reduced in elderly. In a placebo-controlled, double-blinded study, we examined if local injections of rhGH enhance collagen synthesis in healthy elderly men (61 ± 1 yr). Two injections of rhGH or saline (control) were injected into each of the patient's patellar tendons, respectively. Subsequently, tendon collagen fractional synthesis rate (FSR) and an indirect marker of type I collagen synthesis (PINP) were measured. Within the first 6 h after the last injections, a tendency towards a higher tendon collagen FSR was observed in 10 out of 12 subjects (P = 0.08). Similarly, PINP was higher 3-4 h after the last GH injection (P = 0.05). Serum IGF-I did not change from baseline, whereas peritendinous bioactive IGF-I was higher in the GH leg vs. control (P = 0.05). In conclusion, local injections of rhGH increase tendon collagen synthesis in humans, either directly or indirectly by increasing local bioactive IGF-I.",
author = "Vestergaard, {Poul Erik} and J{\o}rgensen, {Jens Otto Lunde} and Jens Olesen and Ermina Bosnjak and Lars Holm and Jan Frystyk and Henning Langberg and Michael Kjaer and Hansen, {Mette Damborg}",
year = "2012",
month = nov,
doi = "10.1152/japplphysiol.00816.2012",
language = "English",
volume = "113",
pages = "1432--8",
journal = "Journal of Applied Physiology",
issn = "8750-7587",
publisher = "American Physiological Society",
number = "9",

}

RIS

TY - JOUR

T1 - Local administration of growth hormone stimulates tendon collagen synthesis in elderly men

AU - Vestergaard, Poul Erik

AU - Jørgensen, Jens Otto Lunde

AU - Olesen, Jens

AU - Bosnjak, Ermina

AU - Holm, Lars

AU - Frystyk, Jan

AU - Langberg, Henning

AU - Kjaer, Michael

AU - Hansen, Mette Damborg

PY - 2012/11

Y1 - 2012/11

N2 - Tendon collagen content and circulating growth hormone (GH) are reduced in elderly. In a placebo-controlled, double-blinded study, we examined if local injections of rhGH enhance collagen synthesis in healthy elderly men (61 ± 1 yr). Two injections of rhGH or saline (control) were injected into each of the patient's patellar tendons, respectively. Subsequently, tendon collagen fractional synthesis rate (FSR) and an indirect marker of type I collagen synthesis (PINP) were measured. Within the first 6 h after the last injections, a tendency towards a higher tendon collagen FSR was observed in 10 out of 12 subjects (P = 0.08). Similarly, PINP was higher 3-4 h after the last GH injection (P = 0.05). Serum IGF-I did not change from baseline, whereas peritendinous bioactive IGF-I was higher in the GH leg vs. control (P = 0.05). In conclusion, local injections of rhGH increase tendon collagen synthesis in humans, either directly or indirectly by increasing local bioactive IGF-I.

AB - Tendon collagen content and circulating growth hormone (GH) are reduced in elderly. In a placebo-controlled, double-blinded study, we examined if local injections of rhGH enhance collagen synthesis in healthy elderly men (61 ± 1 yr). Two injections of rhGH or saline (control) were injected into each of the patient's patellar tendons, respectively. Subsequently, tendon collagen fractional synthesis rate (FSR) and an indirect marker of type I collagen synthesis (PINP) were measured. Within the first 6 h after the last injections, a tendency towards a higher tendon collagen FSR was observed in 10 out of 12 subjects (P = 0.08). Similarly, PINP was higher 3-4 h after the last GH injection (P = 0.05). Serum IGF-I did not change from baseline, whereas peritendinous bioactive IGF-I was higher in the GH leg vs. control (P = 0.05). In conclusion, local injections of rhGH increase tendon collagen synthesis in humans, either directly or indirectly by increasing local bioactive IGF-I.

U2 - 10.1152/japplphysiol.00816.2012

DO - 10.1152/japplphysiol.00816.2012

M3 - Journal article

C2 - 22961272

VL - 113

SP - 1432

EP - 1438

JO - Journal of Applied Physiology

JF - Journal of Applied Physiology

SN - 8750-7587

IS - 9

ER -

ID: 44832886