TY - JOUR

T1 - Intensive Lifestyle Intervention Increases Plasma Midregional Proatrial Natriuretic Peptide Concentrations in Overweight Children

AU - Thomsen, Camilla F.

AU - Goharian, Tina S.

AU - Larsen, Kristian T.

AU - Goetze, Jens P.

AU - Andersen, Lars B.

AU - Jeppesen, Jorgen L.

PY - 2021

Y1 - 2021

N2 - BACKGROUND: Overweight adults have low circulating concentrations of ANP (atrial natriuretic peptide) and proANP fragments. We tested the hypothesis that an intensive lifestyle intervention with an intended weight loss would increase plasma concentrations of a proANP fragment in overweight children.METHODS AND RESULTS: We measured MR-proANP (midregional proANP) concentrations in plasma from overweight children who participated in the OOIS (Odense Overweight Intervention Study). OOIS randomized 115 overweight children (11-13 years, 55% girls) to an intensive day-camp intervention arm with increased physical activity and healthy diet or to a less intensive standard intervention arm for 6 weeks. We used linear mixed-effects modeling for repeated measures to estimate the difference in the mean change with 95% CIs in fasting plasma MR-proANP concentrations between the 2 arms, and we used partial least squares regression analysis to identify candidate mediators. Differences in weight, fitness, and metabolic factors were also analyzed. At baseline, fasting plasma MR-proANP concentrations were (median [interquartile range]) 35.0 pmol/L (26.8-42.0) in the day-camp intervention arm and 37.2 pmol/L (31.7-44.7) in standard intervention arm participants, respectively. After 6 weeks intervention, children in the day-camp intervention arm had increased their MR-proANP (5.4 pmol/L [0.8-10.0], P=0.022) and their fitness (2.33 mL O-2/min per kg [0.52-4.14], P=0.012) and they had deceased their body mass index (-2.12 kg/m(2) [-2.59 to -1.65], PCONCLUSIONS: An intensive lifestyle intervention increases plasma MR-proANP among overweight children.

AB - BACKGROUND: Overweight adults have low circulating concentrations of ANP (atrial natriuretic peptide) and proANP fragments. We tested the hypothesis that an intensive lifestyle intervention with an intended weight loss would increase plasma concentrations of a proANP fragment in overweight children.METHODS AND RESULTS: We measured MR-proANP (midregional proANP) concentrations in plasma from overweight children who participated in the OOIS (Odense Overweight Intervention Study). OOIS randomized 115 overweight children (11-13 years, 55% girls) to an intensive day-camp intervention arm with increased physical activity and healthy diet or to a less intensive standard intervention arm for 6 weeks. We used linear mixed-effects modeling for repeated measures to estimate the difference in the mean change with 95% CIs in fasting plasma MR-proANP concentrations between the 2 arms, and we used partial least squares regression analysis to identify candidate mediators. Differences in weight, fitness, and metabolic factors were also analyzed. At baseline, fasting plasma MR-proANP concentrations were (median [interquartile range]) 35.0 pmol/L (26.8-42.0) in the day-camp intervention arm and 37.2 pmol/L (31.7-44.7) in standard intervention arm participants, respectively. After 6 weeks intervention, children in the day-camp intervention arm had increased their MR-proANP (5.4 pmol/L [0.8-10.0], P=0.022) and their fitness (2.33 mL O-2/min per kg [0.52-4.14], P=0.012) and they had deceased their body mass index (-2.12 kg/m(2) [-2.59 to -1.65], PCONCLUSIONS: An intensive lifestyle intervention increases plasma MR-proANP among overweight children.

KW - atrial natriuretic peptide

KW - children

KW - fitness

KW - overweight

KW - weight loss

KW - NEPRILYSIN INHIBITION

KW - INSULIN SENSITIVITY

KW - CLEARANCE RECEPTOR

KW - RISK-FACTORS

KW - ATRIAL

KW - OBESITY

KW - IMPACT

KW - ASSOCIATIONS

KW - WEIGHT

KW - SYSTEM

U2 - 10.1161/JAHA.121.020676

DO - 10.1161/JAHA.121.020676

M3 - Journal article

C2 - 34180245

VL - 10

JO - Journal of the American Heart Association

JF - Journal of the American Heart Association

SN - 2047-9980

IS - 13

M1 - 020676

ER -