Carotid plaque thickness is increased in chronic kidney disease and associated with carotid and coronary calcification
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Carotid plaque thickness is increased in chronic kidney disease and associated with carotid and coronary calcification. / Bjergfelt, Sasha S.; Sørensen, Ida M.H.; Hjortkjær, Henrik; Landler, Nino; Ballegaard, Ellen L.F.; Biering-Sørensen, Tor; Kofoed, Klaus F.; Lange, Theis; Feldt-Rasmussen, Bo; Sillesen, Henrik; Christoffersen, Christina; Bro, Susanne.
I: PLoS ONE, Bind 16, e0260417, 2021.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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T1 - Carotid plaque thickness is increased in chronic kidney disease and associated with carotid and coronary calcification
AU - Bjergfelt, Sasha S.
AU - Sørensen, Ida M.H.
AU - Hjortkjær, Henrik
AU - Landler, Nino
AU - Ballegaard, Ellen L.F.
AU - Biering-Sørensen, Tor
AU - Kofoed, Klaus F.
AU - Lange, Theis
AU - Feldt-Rasmussen, Bo
AU - Sillesen, Henrik
AU - Christoffersen, Christina
AU - Bro, Susanne
N1 - Publisher Copyright: © 2021 Bjergfelt et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PY - 2021
Y1 - 2021
N2 - Background Chronic kidney disease accelerates both atherosclerosis and arterial calcification. The aim of the present study was to explore whether maximal carotid plaque thickness (cPTmax) was increased in patients with chronic kidney disease compared to controls and associated with cardiovascular disease and severity of calcification in the carotid and coronary arteries. Methods The study group consisted of 200 patients with chronic kidney disease stage 3 from the Copenhagen Chronic Kidney Disease Cohort and 121 age- and sex-matched controls. cPTmax was assessed by ultrasound and arterial calcification by computed tomography scanning. Results Carotid plaques were present in 58% of patients (n = 115) compared with 40% of controls (n = 48), p = 0.002. Among participants with plaques, cPTmax (median, interquartile range) was significantly higher in patients compared with controls (1.9 (1.4-2.3) versus 1.5 (1.2- 1.8) mm), p = 0.001. Cardiovascular disease was present in 9% of patients without plaques (n = 85), 23% of patients with cPTmax 1.0-1.9 mm (n = 69) and 35% of patients with cPTmax >1.9 mm (n = 46), p = 0.001. Carotid and coronary calcium scores >400 were present in 0% and 4%, respectively, of patients with no carotid plaques, in 19% and 24% of patients with cPTmax 1.0-1.9 mm, and in 48% and 53% of patients with cPTmax >1.9 mm, p<0.001. Conclusions This is the first study showing that cPTmax is increased in patients with chronic kidney disease stage 3 compared to controls and closely associated with prevalent cardiovascular disease and severity of calcification in both the carotid and coronary arteries.
AB - Background Chronic kidney disease accelerates both atherosclerosis and arterial calcification. The aim of the present study was to explore whether maximal carotid plaque thickness (cPTmax) was increased in patients with chronic kidney disease compared to controls and associated with cardiovascular disease and severity of calcification in the carotid and coronary arteries. Methods The study group consisted of 200 patients with chronic kidney disease stage 3 from the Copenhagen Chronic Kidney Disease Cohort and 121 age- and sex-matched controls. cPTmax was assessed by ultrasound and arterial calcification by computed tomography scanning. Results Carotid plaques were present in 58% of patients (n = 115) compared with 40% of controls (n = 48), p = 0.002. Among participants with plaques, cPTmax (median, interquartile range) was significantly higher in patients compared with controls (1.9 (1.4-2.3) versus 1.5 (1.2- 1.8) mm), p = 0.001. Cardiovascular disease was present in 9% of patients without plaques (n = 85), 23% of patients with cPTmax 1.0-1.9 mm (n = 69) and 35% of patients with cPTmax >1.9 mm (n = 46), p = 0.001. Carotid and coronary calcium scores >400 were present in 0% and 4%, respectively, of patients with no carotid plaques, in 19% and 24% of patients with cPTmax 1.0-1.9 mm, and in 48% and 53% of patients with cPTmax >1.9 mm, p<0.001. Conclusions This is the first study showing that cPTmax is increased in patients with chronic kidney disease stage 3 compared to controls and closely associated with prevalent cardiovascular disease and severity of calcification in both the carotid and coronary arteries.
U2 - 10.1371/journal.pone.0260417
DO - 10.1371/journal.pone.0260417
M3 - Journal article
C2 - 34813630
AN - SCOPUS:85120068301
VL - 16
JO - PLoS ONE
JF - PLoS ONE
SN - 1932-6203
M1 - e0260417
ER -
ID: 286996026