Walking Time Is Associated With Hippocampal Volume in Overweight and Obese Office Workers

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

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Walking Time Is Associated With Hippocampal Volume in Overweight and Obese Office Workers. / Bergman, Frida; Matsson-Frost, Tove; Jonasson, Lars; Chorell, Elin; Sörlin, Ann; Wennberg, Patrik; Öhberg, Fredrik; Ryberg, Mats; Levine, James A.; Olsson, Tommy; Boraxbekk, Carl Johan.

I: Frontiers in Human Neuroscience, Bind 14, 307, 2020.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Bergman, F, Matsson-Frost, T, Jonasson, L, Chorell, E, Sörlin, A, Wennberg, P, Öhberg, F, Ryberg, M, Levine, JA, Olsson, T & Boraxbekk, CJ 2020, 'Walking Time Is Associated With Hippocampal Volume in Overweight and Obese Office Workers', Frontiers in Human Neuroscience, bind 14, 307. https://doi.org/10.3389/fnhum.2020.00307

APA

Bergman, F., Matsson-Frost, T., Jonasson, L., Chorell, E., Sörlin, A., Wennberg, P., Öhberg, F., Ryberg, M., Levine, J. A., Olsson, T., & Boraxbekk, C. J. (2020). Walking Time Is Associated With Hippocampal Volume in Overweight and Obese Office Workers. Frontiers in Human Neuroscience, 14, [307]. https://doi.org/10.3389/fnhum.2020.00307

Vancouver

Bergman F, Matsson-Frost T, Jonasson L, Chorell E, Sörlin A, Wennberg P o.a. Walking Time Is Associated With Hippocampal Volume in Overweight and Obese Office Workers. Frontiers in Human Neuroscience. 2020;14. 307. https://doi.org/10.3389/fnhum.2020.00307

Author

Bergman, Frida ; Matsson-Frost, Tove ; Jonasson, Lars ; Chorell, Elin ; Sörlin, Ann ; Wennberg, Patrik ; Öhberg, Fredrik ; Ryberg, Mats ; Levine, James A. ; Olsson, Tommy ; Boraxbekk, Carl Johan. / Walking Time Is Associated With Hippocampal Volume in Overweight and Obese Office Workers. I: Frontiers in Human Neuroscience. 2020 ; Bind 14.

Bibtex

@article{cb05916c59494f088b7d0679a3f3d037,

title = "Walking Time Is Associated With Hippocampal Volume in Overweight and Obese Office Workers",

abstract = "Objectives: To investigate the long-term effects on cognition and brain function after installing treadmill workstations in offices for 13 months. Methods: Eighty healthy overweight or obese office workers aged 40–67 years were individually randomized to an intervention group, receiving a treadmill workstation and encouraging emails, or to a control group, continuing to work as usual. Effects on cognitive function, hippocampal volume, prefrontal cortex (PFC) thickness, and circulating brain-derived neurotrophic factor (BDNF) were analyzed. Further, mediation analyses between changes in walking time and light-intensity physical activity (LPA) on changes in BDNF and hippocampal volume between baseline and 13 months, and multivariate analyses of the baseline data with percentage sitting time as the response variable, were performed. Results: No group by time interactions were observed for any of the outcomes. In the mediation analyses, positive associations between changes in walking time and LPA on changes in hippocampal volume were observed, although not mediated by changes in BDNF levels. In the multivariate analyses, a negative association between percentage sitting time and hippocampal volume was observed, however only among those older than 51 years of age. Conclusion: Although no group by time interactions were observed, our analyses suggest that increased walking and LPA may have positive effects on hippocampal volume and that sedentary behavior is associated with brain structures of importance for memory functions. Trial Registration: www.ClinicalTrials.gov as NCT01997970.",

keywords = "brain function, cognition, office work, physical activity, randomized controlled trial, sedentary behavior",

author = "Frida Bergman and Tove Matsson-Frost and Lars Jonasson and Elin Chorell and Ann S{\"o}rlin and Patrik Wennberg and Fredrik {\"O}hberg and Mats Ryberg and Levine, {James A.} and Tommy Olsson and Boraxbekk, {Carl Johan}",

note = "Publisher Copyright: {\textcopyright} Copyright {\textcopyright} 2020 Bergman, Matsson-Frost, Jonasson, Chorell, S{\"o}rlin, Wennberg, {\"O}hberg, Ryberg, Levine, Olsson and Boraxbekk.",

year = "2020",

doi = "10.3389/fnhum.2020.00307",

language = "English",

volume = "14",

journal = "Frontiers in Human Neuroscience",

issn = "1662-5161",

publisher = "Frontiers Research Foundation",

}

RIS

TY - JOUR

T1 - Walking Time Is Associated With Hippocampal Volume in Overweight and Obese Office Workers

AU - Bergman, Frida

AU - Matsson-Frost, Tove

AU - Jonasson, Lars

AU - Chorell, Elin

AU - Sörlin, Ann

AU - Wennberg, Patrik

AU - Öhberg, Fredrik

AU - Ryberg, Mats

AU - Levine, James A.

AU - Olsson, Tommy

AU - Boraxbekk, Carl Johan

PY - 2020

Y1 - 2020

N2 - Objectives: To investigate the long-term effects on cognition and brain function after installing treadmill workstations in offices for 13 months. Methods: Eighty healthy overweight or obese office workers aged 40–67 years were individually randomized to an intervention group, receiving a treadmill workstation and encouraging emails, or to a control group, continuing to work as usual. Effects on cognitive function, hippocampal volume, prefrontal cortex (PFC) thickness, and circulating brain-derived neurotrophic factor (BDNF) were analyzed. Further, mediation analyses between changes in walking time and light-intensity physical activity (LPA) on changes in BDNF and hippocampal volume between baseline and 13 months, and multivariate analyses of the baseline data with percentage sitting time as the response variable, were performed. Results: No group by time interactions were observed for any of the outcomes. In the mediation analyses, positive associations between changes in walking time and LPA on changes in hippocampal volume were observed, although not mediated by changes in BDNF levels. In the multivariate analyses, a negative association between percentage sitting time and hippocampal volume was observed, however only among those older than 51 years of age. Conclusion: Although no group by time interactions were observed, our analyses suggest that increased walking and LPA may have positive effects on hippocampal volume and that sedentary behavior is associated with brain structures of importance for memory functions. Trial Registration: www.ClinicalTrials.gov as NCT01997970.

AB - Objectives: To investigate the long-term effects on cognition and brain function after installing treadmill workstations in offices for 13 months. Methods: Eighty healthy overweight or obese office workers aged 40–67 years were individually randomized to an intervention group, receiving a treadmill workstation and encouraging emails, or to a control group, continuing to work as usual. Effects on cognitive function, hippocampal volume, prefrontal cortex (PFC) thickness, and circulating brain-derived neurotrophic factor (BDNF) were analyzed. Further, mediation analyses between changes in walking time and light-intensity physical activity (LPA) on changes in BDNF and hippocampal volume between baseline and 13 months, and multivariate analyses of the baseline data with percentage sitting time as the response variable, were performed. Results: No group by time interactions were observed for any of the outcomes. In the mediation analyses, positive associations between changes in walking time and LPA on changes in hippocampal volume were observed, although not mediated by changes in BDNF levels. In the multivariate analyses, a negative association between percentage sitting time and hippocampal volume was observed, however only among those older than 51 years of age. Conclusion: Although no group by time interactions were observed, our analyses suggest that increased walking and LPA may have positive effects on hippocampal volume and that sedentary behavior is associated with brain structures of importance for memory functions. Trial Registration: www.ClinicalTrials.gov as NCT01997970.

KW - brain function

KW - cognition

KW - office work

KW - physical activity

KW - randomized controlled trial

KW - sedentary behavior

U2 - 10.3389/fnhum.2020.00307

DO - 10.3389/fnhum.2020.00307

M3 - Journal article

AN - SCOPUS:85090298824

VL - 14

JO - Frontiers in Human Neuroscience

JF - Frontiers in Human Neuroscience

SN - 1662-5161

M1 - 307

ER -

ID: 332184566