Volume and dimensions of angiographically normal coronary arteries assessed by multidetector computed tomography
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Volume and dimensions of angiographically normal coronary arteries assessed by multidetector computed tomography. / Sørensen, Samuel Kiil; Kühl, Jørgen Tobias; Fuchs, Andreas; Norsk, Jakob Boesgaard; Køber, Lars Valeur; Nordestgaard, Børge Grønne; Kofoed, Klaus Fuglsang.
I: Journal of Cardiovascular Computed Tomography, Bind 11, Nr. 4, 2017, s. 295-301.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Volume and dimensions of angiographically normal coronary arteries assessed by multidetector computed tomography
AU - Sørensen, Samuel Kiil
AU - Kühl, Jørgen Tobias
AU - Fuchs, Andreas
AU - Norsk, Jakob Boesgaard
AU - Køber, Lars Valeur
AU - Nordestgaard, Børge Grønne
AU - Kofoed, Klaus Fuglsang
N1 - Copyright © 2017 Society of Cardiovascular Computed Tomography. Published by Elsevier Inc. All rights reserved.
PY - 2017
Y1 - 2017
N2 - BACKGROUND: The objective of this study was to determine normal values for coronary artery volume (CAV) and individual vasculature and segment dimensions.METHODS: We examined 200 healthy volunteers with an Agatston score of 0 and a normal, high quality coronary CTA. Using 320 slice multidetector row CT and designated vessel tracing software with border detection algorithm, the main coronary arteries and branches were delineated and total and segmental dimensions calculated.RESULTS: 2931 segments (98.9%) could be adequately delineated. Of the 173 subjects with adequate coronary delineations, 140 subjects (81%) received nitroglycerin (NTG) prior to the scan. CAV was 4.33 ml (95% CI: 2.27-6.39) in subjects with NTG and 2.55 ml (95% CI: 0.34-4.76) in subjects without NTG (p < 0.0001). Left ventricular mass (LVM) was strongly correlated with CAV (p < 0.0001) independently of body surface area and gender, whereas gender was not independently correlated with CAV. From right, balanced to left coronary dominance, the left anterior descending artery vasculature mean contribution to CAV increased slightly (37%, 40% and 43%, p = 0.002), and the mean contributions of right coronary artery (RCA) and left circumflex artery (LCX) vasculature was inversely related - from right, balanced to left 46%, 32% and 16% for RCA (p < 0.0001); and 16%, 27% and 38% for LCX (p < 0.0001).CONCLUSION: Normal values for coronary artery volume as assessed by coronary CTA are reported. They strongly correlate with NTG administration and left ventricular mass. The respective contribution of the left and right coronary vascularture is influenced by coronary dominance.
AB - BACKGROUND: The objective of this study was to determine normal values for coronary artery volume (CAV) and individual vasculature and segment dimensions.METHODS: We examined 200 healthy volunteers with an Agatston score of 0 and a normal, high quality coronary CTA. Using 320 slice multidetector row CT and designated vessel tracing software with border detection algorithm, the main coronary arteries and branches were delineated and total and segmental dimensions calculated.RESULTS: 2931 segments (98.9%) could be adequately delineated. Of the 173 subjects with adequate coronary delineations, 140 subjects (81%) received nitroglycerin (NTG) prior to the scan. CAV was 4.33 ml (95% CI: 2.27-6.39) in subjects with NTG and 2.55 ml (95% CI: 0.34-4.76) in subjects without NTG (p < 0.0001). Left ventricular mass (LVM) was strongly correlated with CAV (p < 0.0001) independently of body surface area and gender, whereas gender was not independently correlated with CAV. From right, balanced to left coronary dominance, the left anterior descending artery vasculature mean contribution to CAV increased slightly (37%, 40% and 43%, p = 0.002), and the mean contributions of right coronary artery (RCA) and left circumflex artery (LCX) vasculature was inversely related - from right, balanced to left 46%, 32% and 16% for RCA (p < 0.0001); and 16%, 27% and 38% for LCX (p < 0.0001).CONCLUSION: Normal values for coronary artery volume as assessed by coronary CTA are reported. They strongly correlate with NTG administration and left ventricular mass. The respective contribution of the left and right coronary vascularture is influenced by coronary dominance.
KW - Adult
KW - Algorithms
KW - Automation
KW - Computed Tomography Angiography
KW - Coronary Angiography/methods
KW - Coronary Vessels/diagnostic imaging
KW - Female
KW - Humans
KW - Male
KW - Middle Aged
KW - Multidetector Computed Tomography
KW - Nitroglycerin/administration & dosage
KW - Predictive Value of Tests
KW - Radiographic Image Interpretation, Computer-Assisted
KW - Reference Values
KW - Software
KW - Vasodilator Agents/administration & dosage
U2 - 10.1016/j.jcct.2017.04.001
DO - 10.1016/j.jcct.2017.04.001
M3 - Journal article
C2 - 28420590
VL - 11
SP - 295
EP - 301
JO - Journal of Cardiovascular Computed Tomography
JF - Journal of Cardiovascular Computed Tomography
SN - 1934-5925
IS - 4
ER -
ID: 194623336