Vitamin E and acute graft-versus-host disease after myeloablative allogeneic hematopoietic cell transplantation
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Vitamin E and acute graft-versus-host disease after myeloablative allogeneic hematopoietic cell transplantation. / Gjaerde, Lars Klingen; Ostrowski, Sisse Rye; Minculescu, Lia; Andersen, Niels Smedegaard; Friis, Lone Smidstrup; Kornblit, Brian; Petersen, Soren Lykke; Schjodt, Ida; Sengelov, Henrik.
I: European Journal of Haematology, Bind 106, Nr. 3, 2021, s. 417-424.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Vitamin E and acute graft-versus-host disease after myeloablative allogeneic hematopoietic cell transplantation
AU - Gjaerde, Lars Klingen
AU - Ostrowski, Sisse Rye
AU - Minculescu, Lia
AU - Andersen, Niels Smedegaard
AU - Friis, Lone Smidstrup
AU - Kornblit, Brian
AU - Petersen, Soren Lykke
AU - Schjodt, Ida
AU - Sengelov, Henrik
PY - 2021
Y1 - 2021
N2 - Objectives Vitamin E has antioxidant and immunomodulatory effects that might influence the development of acute graft-versus-host disease (GvHD). We investigated the association between plasma vitamin E levels and acute GvHD.Methods We studied 115 adults who underwent myeloablative allogeneic hematopoietic cell transplantation between July 2015 and August 2018. Vitamin E was measured by high-performance liquid chromatography in stored plasma samples obtained pre-transplantation at day -23 (+/- 15 days) and post-transplantation at day +28 (+/- 3 days).Results Pre-transplantation vitamin E levels were inversely associated with grade II-IV acute GvHD (hazard ratio 0.68 per 10 mu mol/L increase, 95% confidence interval [CI]: 0.47-0.98). The association remained after adjustment for known prognostic factors for acute GvHD. Patients with levels below the median had a cumulative incidence of grade II-IV acute GvHD of 46% (CI: 33-59%) versus 21% (CI: 10-32%) in patients with levels above the median. No clear association with non-relapse mortality, relapse, or chronic GvHD was found. Post-transplantation vitamin E levels (measured in 72 [63%] patients) were correlated with pre-transplantation levels (rho = .31) but were not associated with subsequent grade II-IV acute GvHD.Conclusions High pre-transplantation vitamin E levels were associated with less acute GvHD.
AB - Objectives Vitamin E has antioxidant and immunomodulatory effects that might influence the development of acute graft-versus-host disease (GvHD). We investigated the association between plasma vitamin E levels and acute GvHD.Methods We studied 115 adults who underwent myeloablative allogeneic hematopoietic cell transplantation between July 2015 and August 2018. Vitamin E was measured by high-performance liquid chromatography in stored plasma samples obtained pre-transplantation at day -23 (+/- 15 days) and post-transplantation at day +28 (+/- 3 days).Results Pre-transplantation vitamin E levels were inversely associated with grade II-IV acute GvHD (hazard ratio 0.68 per 10 mu mol/L increase, 95% confidence interval [CI]: 0.47-0.98). The association remained after adjustment for known prognostic factors for acute GvHD. Patients with levels below the median had a cumulative incidence of grade II-IV acute GvHD of 46% (CI: 33-59%) versus 21% (CI: 10-32%) in patients with levels above the median. No clear association with non-relapse mortality, relapse, or chronic GvHD was found. Post-transplantation vitamin E levels (measured in 72 [63%] patients) were correlated with pre-transplantation levels (rho = .31) but were not associated with subsequent grade II-IV acute GvHD.Conclusions High pre-transplantation vitamin E levels were associated with less acute GvHD.
KW - acute graft‐
KW - versus‐
KW - host disease
KW - allogeneic hematopoietic cell transplantation
KW - vitamin E
KW - T-HELPER-1 CYTOKINE PRODUCTION
KW - HIGH-DOSE CHEMOTHERAPY
KW - ALPHA-TOCOPHEROL
KW - ANTIOXIDANT STATUS
KW - PLASMA
KW - SUPPLEMENTATION
KW - ADHESION
KW - RECIPIENTS
KW - MUCOSITIS
U2 - 10.1111/ejh.13567
DO - 10.1111/ejh.13567
M3 - Journal article
C2 - 33314420
VL - 106
SP - 417
EP - 424
JO - European Journal of Haematology
JF - European Journal of Haematology
SN - 0902-4441
IS - 3
ER -
ID: 269916055