Vitamin D prenatal programming of childhood metabolomics profiles at age 3 y
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Vitamin D prenatal programming of childhood metabolomics profiles at age 3 y. / Blighe, Kevin; Chawes, Bo L; Kelly, Rachel S; Mirzakhani, Hooman; McGeachie, Michael; Litonjua, Augusto A; Weiss, Scott T; Lasky-Su, Jessica A.
I: The American Journal of Clinical Nutrition, Bind 106, Nr. 4, 2017, s. 1092-1099.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Vitamin D prenatal programming of childhood metabolomics profiles at age 3 y
AU - Blighe, Kevin
AU - Chawes, Bo L
AU - Kelly, Rachel S
AU - Mirzakhani, Hooman
AU - McGeachie, Michael
AU - Litonjua, Augusto A
AU - Weiss, Scott T
AU - Lasky-Su, Jessica A
N1 - © 2017 American Society for Nutrition.
PY - 2017
Y1 - 2017
N2 - Background: Vitamin D deficiency is implicated in a range of common complex diseases that may be prevented by gestational vitamin D repletion. Understanding the metabolic mechanisms related to in utero vitamin D exposure may therefore shed light on complex disease susceptibility.Objective: The goal was to analyze the programming role of in utero vitamin D exposure on children's metabolomics profiles.Design: First, unsupervised clustering was done with plasma metabolomics profiles from a case-control subset of 245 children aged 3 y with and without asthma from the Vitamin D Antenatal Asthma Reduction Trial (VDAART), in which pregnant women were randomly assigned to vitamin D supplementation or placebo. Thereafter, we analyzed the influence of maternal pre- and postsupplement vitamin D concentrations on cluster membership. Finally, we used the metabolites driving the clustering of children to identify the dominant metabolic pathways that were influential in each cluster.Results: We identified 3 clusters of children characterized by 1) high concentrations of fatty acids and amines and low maternal postsupplement vitamin D (mean ± SD; 27.5 ± 11.0 ng/mL), 2) high concentrations of amines, moderate concentrations of fatty acids, and normal maternal postsupplement vitamin D (34.0 ± 14.1 ng/mL), and 3) low concentrations of fatty acids, amines, and normal maternal postsupplement vitamin D (35.2 ± 15.9 ng/mL). Adjusting for sample storage time, maternal age and education, and both child asthma and vitamin D concentration at age 3 y did not modify the association between maternal postsupplement vitamin D and cluster membership (P = 0.0014). Maternal presupplement vitamin D did not influence cluster membership, whereas the combination of pre- and postsupplement concentrations did (P = 0.03).Conclusions: Young children can be clustered into distinct biologically meaningful groups by their metabolomics profiles. The clusters differed in concentrations of inflammatory mediators, and cluster membership was influenced by in utero vitamin D exposure, suggesting a prenatal programming role of vitamin D on the child's metabolome. This trial was registered at clinicaltrials.gov as NCT00920621.
AB - Background: Vitamin D deficiency is implicated in a range of common complex diseases that may be prevented by gestational vitamin D repletion. Understanding the metabolic mechanisms related to in utero vitamin D exposure may therefore shed light on complex disease susceptibility.Objective: The goal was to analyze the programming role of in utero vitamin D exposure on children's metabolomics profiles.Design: First, unsupervised clustering was done with plasma metabolomics profiles from a case-control subset of 245 children aged 3 y with and without asthma from the Vitamin D Antenatal Asthma Reduction Trial (VDAART), in which pregnant women were randomly assigned to vitamin D supplementation or placebo. Thereafter, we analyzed the influence of maternal pre- and postsupplement vitamin D concentrations on cluster membership. Finally, we used the metabolites driving the clustering of children to identify the dominant metabolic pathways that were influential in each cluster.Results: We identified 3 clusters of children characterized by 1) high concentrations of fatty acids and amines and low maternal postsupplement vitamin D (mean ± SD; 27.5 ± 11.0 ng/mL), 2) high concentrations of amines, moderate concentrations of fatty acids, and normal maternal postsupplement vitamin D (34.0 ± 14.1 ng/mL), and 3) low concentrations of fatty acids, amines, and normal maternal postsupplement vitamin D (35.2 ± 15.9 ng/mL). Adjusting for sample storage time, maternal age and education, and both child asthma and vitamin D concentration at age 3 y did not modify the association between maternal postsupplement vitamin D and cluster membership (P = 0.0014). Maternal presupplement vitamin D did not influence cluster membership, whereas the combination of pre- and postsupplement concentrations did (P = 0.03).Conclusions: Young children can be clustered into distinct biologically meaningful groups by their metabolomics profiles. The clusters differed in concentrations of inflammatory mediators, and cluster membership was influenced by in utero vitamin D exposure, suggesting a prenatal programming role of vitamin D on the child's metabolome. This trial was registered at clinicaltrials.gov as NCT00920621.
KW - Adult
KW - Amines/blood
KW - Asthma
KW - Child Health
KW - Child, Preschool
KW - Dietary Supplements
KW - Disease Susceptibility
KW - Fatty Acids/blood
KW - Female
KW - Humans
KW - Inflammation/blood
KW - Inflammation Mediators/blood
KW - Male
KW - Metabolic Networks and Pathways
KW - Metabolome/drug effects
KW - Metabolomics
KW - Pregnancy
KW - Pregnancy Complications/blood
KW - Prenatal Exposure Delayed Effects
KW - Vitamin D/blood
KW - Vitamin D Deficiency/blood
KW - Vitamins/blood
KW - Young Adult
U2 - 10.3945/ajcn.117.158220
DO - 10.3945/ajcn.117.158220
M3 - Journal article
C2 - 28835366
VL - 106
SP - 1092
EP - 1099
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
SN - 0002-9165
IS - 4
ER -
ID: 195190751