Vertebral bone marrow (Modic) changes

Publikation: Bidrag til bog/antologi/rapport › Bidrag til bog/antologi › Forskning › fagfællebedømt

Standard

Vertebral bone marrow (Modic) changes. / Määttä, Juhani; Jensen, Tue Secher; Udby, Peter M.; Barajas, J. Nicolás; Samartzis, Dino; Niinimäki, Jaakko; Karppinen, Jaro I.

Spine Phenotypes. Academic Press, 2022. s. 223-252.

Publikation: Bidrag til bog/antologi/rapport › Bidrag til bog/antologi › Forskning › fagfællebedømt

Harvard

Määttä, J, Jensen, TS, Udby, PM, Barajas, JN, Samartzis, D, Niinimäki, J & Karppinen, JI 2022, Vertebral bone marrow (Modic) changes. i Spine Phenotypes. Academic Press, s. 223-252. https://doi.org/10.1016/B978-0-12-822778-7.00019-5

APA

Määttä, J., Jensen, T. S., Udby, P. M., Barajas, J. N., Samartzis, D., Niinimäki, J., & Karppinen, J. I. (2022). Vertebral bone marrow (Modic) changes. I Spine Phenotypes (s. 223-252). Academic Press. https://doi.org/10.1016/B978-0-12-822778-7.00019-5

Vancouver

Määttä J, Jensen TS, Udby PM, Barajas JN, Samartzis D, Niinimäki J o.a. Vertebral bone marrow (Modic) changes. I Spine Phenotypes. Academic Press. 2022. s. 223-252 https://doi.org/10.1016/B978-0-12-822778-7.00019-5

Author

Määttä, Juhani ; Jensen, Tue Secher ; Udby, Peter M. ; Barajas, J. Nicolás ; Samartzis, Dino ; Niinimäki, Jaakko ; Karppinen, Jaro I. / Vertebral bone marrow (Modic) changes. Spine Phenotypes. Academic Press, 2022. s. 223-252

Bibtex

@inbook{a5ed170548e6490a80ec95a12b8b9bd2,

title = "Vertebral bone marrow (Modic) changes",

abstract = "Modic changes (MCs) are bone marrow changes in the spine, and they are classified into three categories (types 1, 2, and 3) based on magnetic resonance imaging (MRI) appearance. They share several determinants with bone marrow changes at other sites of the body. The precise pathology of MCs is still unclear but includes structural disc damage and the inflammatory response to it, atypical mechanical loading, and possible bacterial etiology. In particular, Modic type 1 change (MC1) is thought to be associated with low back pain (LBP) but may also occur among the normal, asymptomatic population. However, MC1 may play a role, especially among patients with chronic, troublesome LBP. Clinically, MCs are diagnosed using MRI with no evident clinical tests or diagnostic algorithms. Unfortunately, no evidence-based treatment options exist yet for patients with pain and MCs although fusion surgery, antibiotic, and nerve ablation treatment are being explored. Overall, MCs are clinically important structural spine phenotypes, with varied etiology and prognostics and a need for refined classification.",

keywords = "Bone marrow edema, Endplate changes, Modic changes, Subchondral bone marrow, Vertebral bone marrow",

author = "Juhani M{\"a}{\"a}tt{\"a} and Jensen, {Tue Secher} and Udby, {Peter M.} and Barajas, {J. Nicol{\'a}s} and Dino Samartzis and Jaakko Niinim{\"a}ki and Karppinen, {Jaro I.}",

year = "2022",

doi = "10.1016/B978-0-12-822778-7.00019-5",

language = "English",

isbn = "9780128227794",

pages = "223--252",

booktitle = "Spine Phenotypes",

publisher = "Academic Press",

address = "United States",

}

RIS

TY - CHAP

T1 - Vertebral bone marrow (Modic) changes

AU - Määttä, Juhani

AU - Jensen, Tue Secher

AU - Udby, Peter M.

AU - Barajas, J. Nicolás

AU - Samartzis, Dino

AU - Niinimäki, Jaakko

AU - Karppinen, Jaro I.

PY - 2022

Y1 - 2022

N2 - Modic changes (MCs) are bone marrow changes in the spine, and they are classified into three categories (types 1, 2, and 3) based on magnetic resonance imaging (MRI) appearance. They share several determinants with bone marrow changes at other sites of the body. The precise pathology of MCs is still unclear but includes structural disc damage and the inflammatory response to it, atypical mechanical loading, and possible bacterial etiology. In particular, Modic type 1 change (MC1) is thought to be associated with low back pain (LBP) but may also occur among the normal, asymptomatic population. However, MC1 may play a role, especially among patients with chronic, troublesome LBP. Clinically, MCs are diagnosed using MRI with no evident clinical tests or diagnostic algorithms. Unfortunately, no evidence-based treatment options exist yet for patients with pain and MCs although fusion surgery, antibiotic, and nerve ablation treatment are being explored. Overall, MCs are clinically important structural spine phenotypes, with varied etiology and prognostics and a need for refined classification.

AB - Modic changes (MCs) are bone marrow changes in the spine, and they are classified into three categories (types 1, 2, and 3) based on magnetic resonance imaging (MRI) appearance. They share several determinants with bone marrow changes at other sites of the body. The precise pathology of MCs is still unclear but includes structural disc damage and the inflammatory response to it, atypical mechanical loading, and possible bacterial etiology. In particular, Modic type 1 change (MC1) is thought to be associated with low back pain (LBP) but may also occur among the normal, asymptomatic population. However, MC1 may play a role, especially among patients with chronic, troublesome LBP. Clinically, MCs are diagnosed using MRI with no evident clinical tests or diagnostic algorithms. Unfortunately, no evidence-based treatment options exist yet for patients with pain and MCs although fusion surgery, antibiotic, and nerve ablation treatment are being explored. Overall, MCs are clinically important structural spine phenotypes, with varied etiology and prognostics and a need for refined classification.

KW - Bone marrow edema

KW - Endplate changes

KW - Modic changes

KW - Subchondral bone marrow

KW - Vertebral bone marrow

U2 - 10.1016/B978-0-12-822778-7.00019-5

DO - 10.1016/B978-0-12-822778-7.00019-5

M3 - Book chapter

AN - SCOPUS:85142583248

SN - 9780128227794

SP - 223

EP - 252

BT - Spine Phenotypes

PB - Academic Press

ER -

ID: 335696096