Validation and incorporation of digital entheses into a preliminary GLobal OMERACT Ultrasound DActylitis Score (GLOUDAS) in psoriatic arthritis
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Validation and incorporation of digital entheses into a preliminary GLobal OMERACT Ultrasound DActylitis Score (GLOUDAS) in psoriatic arthritis. / Naredo, Esperanza; D'Agostino, Maria Antonietta; Terslev, Lene; Pineda, Carlos; Miguel, M. Isabel; Blasi, Joan; Bruyn, George A.; Kortekaas, Marion C.; Mandl, Peter; Nestorova, Rodina; Szkudlarek, Marcin; Todorov, Plamen; Vlad, Violeta; Wong, Priscilla; Bakewell, Catherine; Filippucci, Emilio; Zabotti, Alen; Micu, Mihaela; Vreju, Florentin; Mortada, Mohamed; Mendonça, José Alexandre; Guillen-Astete, Carlos A.; Olivas-Vergara, Otto; Iagnocco, Annamaria; Hanova, Petra; Tinazzi, Ilaria; Balint, Peter V.; Aydin, Sibel Zehra; Kane, David; Keen, Helen; Kaeley, Gurjit S.; Möller, Ingrid.
I: Annals of the Rheumatic Diseases, Bind 83, Nr. 8, 2024, s. 1060-1071.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Validation and incorporation of digital entheses into a preliminary GLobal OMERACT Ultrasound DActylitis Score (GLOUDAS) in psoriatic arthritis
AU - Naredo, Esperanza
AU - D'Agostino, Maria Antonietta
AU - Terslev, Lene
AU - Pineda, Carlos
AU - Miguel, M. Isabel
AU - Blasi, Joan
AU - Bruyn, George A.
AU - Kortekaas, Marion C.
AU - Mandl, Peter
AU - Nestorova, Rodina
AU - Szkudlarek, Marcin
AU - Todorov, Plamen
AU - Vlad, Violeta
AU - Wong, Priscilla
AU - Bakewell, Catherine
AU - Filippucci, Emilio
AU - Zabotti, Alen
AU - Micu, Mihaela
AU - Vreju, Florentin
AU - Mortada, Mohamed
AU - Mendonça, José Alexandre
AU - Guillen-Astete, Carlos A.
AU - Olivas-Vergara, Otto
AU - Iagnocco, Annamaria
AU - Hanova, Petra
AU - Tinazzi, Ilaria
AU - Balint, Peter V.
AU - Aydin, Sibel Zehra
AU - Kane, David
AU - Keen, Helen
AU - Kaeley, Gurjit S.
AU - Möller, Ingrid
N1 - Publisher Copyright: © Author(s) (or their employer(s)) 2024. No commercial re-use. See rights and permissions. Published by BMJ on behalf of EULAR.
PY - 2024
Y1 - 2024
N2 - Objectives The main objective was to generate a GLobal OMERACT Ultrasound DActylitis Score (GLOUDAS) in psoriatic arthritis and to test its reliability. To this end, we assessed the validity, feasibility and applicability of ultrasound assessment of finger entheses to incorporate them into the scoring system. Methods The study consisted of a stepwise process. First, in cadaveric specimens, we identified enthesis sites of the fingers by ultrasound and gross anatomy, and then verified presence of entheseal tissue in histological samples. We then selected the entheses to be incorporated into a dactylitis scoring system through a Delphi consensus process among international experts. Next, we established and defined the ultrasound components of dactylitis and their scoring systems using Delphi methodology. Finally, we tested the interobserver and intraobserver reliability of the consensus- based scoring systemin patients with psoriatic dactylitis. Results 32 entheses were identified in cadaveric fingers. The presence of entheseal tissues was confirmed in all cadaveric samples. Of these, following the consensus process, 12 entheses were selected for inclusion in GLOUDAS. Ultrasound components of GLOUDAS agreed on through the Delphi process were synovitis, tenosynovitis, enthesitis, subcutaneous tissue inflammation and periextensor tendon inflammation. The scoring system for each component was also agreed on. Interobserver reliability was fair to good (κ 0.39-0.71) and intraobserver reliability good to excellent (κ 0.80-0.88) for dactylitis components. Interobserver and intraobserver agreement for the total B-mode and Doppler mode scores (sum of the scores of the individual abnormalities) were excellent (interobserver intraclass correlation coefficient (ICC) 0.98 for B-mode and 0.99 for Doppler mode; intraobserver ICC 0.98 for both modes).
AB - Objectives The main objective was to generate a GLobal OMERACT Ultrasound DActylitis Score (GLOUDAS) in psoriatic arthritis and to test its reliability. To this end, we assessed the validity, feasibility and applicability of ultrasound assessment of finger entheses to incorporate them into the scoring system. Methods The study consisted of a stepwise process. First, in cadaveric specimens, we identified enthesis sites of the fingers by ultrasound and gross anatomy, and then verified presence of entheseal tissue in histological samples. We then selected the entheses to be incorporated into a dactylitis scoring system through a Delphi consensus process among international experts. Next, we established and defined the ultrasound components of dactylitis and their scoring systems using Delphi methodology. Finally, we tested the interobserver and intraobserver reliability of the consensus- based scoring systemin patients with psoriatic dactylitis. Results 32 entheses were identified in cadaveric fingers. The presence of entheseal tissues was confirmed in all cadaveric samples. Of these, following the consensus process, 12 entheses were selected for inclusion in GLOUDAS. Ultrasound components of GLOUDAS agreed on through the Delphi process were synovitis, tenosynovitis, enthesitis, subcutaneous tissue inflammation and periextensor tendon inflammation. The scoring system for each component was also agreed on. Interobserver reliability was fair to good (κ 0.39-0.71) and intraobserver reliability good to excellent (κ 0.80-0.88) for dactylitis components. Interobserver and intraobserver agreement for the total B-mode and Doppler mode scores (sum of the scores of the individual abnormalities) were excellent (interobserver intraclass correlation coefficient (ICC) 0.98 for B-mode and 0.99 for Doppler mode; intraobserver ICC 0.98 for both modes).
U2 - 10.1136/ard-2023-225278
DO - 10.1136/ard-2023-225278
M3 - Journal article
C2 - 38531611
AN - SCOPUS:85190122657
VL - 83
SP - 1060
EP - 1071
JO - Annals of the Rheumatic Diseases
JF - Annals of the Rheumatic Diseases
SN - 0003-4967
IS - 8
ER -
ID: 395996012