Uteroglobin, an apically secreted protein of the uterine epithelium, is secreted non-polarized form MDCK cells and mainly basolaterally from Caco-2 cells

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Standard

Uteroglobin, an apically secreted protein of the uterine epithelium, is secreted non-polarized form MDCK cells and mainly basolaterally from Caco-2 cells. / Vogel, L K; Suske, G; Beato, M; Norén, Ove; Sjöström, H.

I: FEBS Letters, Bind 330, Nr. 3, 1993, s. 293-6.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Vogel, LK, Suske, G, Beato, M, Norén, O & Sjöström, H 1993, 'Uteroglobin, an apically secreted protein of the uterine epithelium, is secreted non-polarized form MDCK cells and mainly basolaterally from Caco-2 cells', FEBS Letters, bind 330, nr. 3, s. 293-6.

APA

Vogel, L. K., Suske, G., Beato, M., Norén, O., & Sjöström, H. (1993). Uteroglobin, an apically secreted protein of the uterine epithelium, is secreted non-polarized form MDCK cells and mainly basolaterally from Caco-2 cells. FEBS Letters, 330(3), 293-6.

Vancouver

Vogel LK, Suske G, Beato M, Norén O, Sjöström H. Uteroglobin, an apically secreted protein of the uterine epithelium, is secreted non-polarized form MDCK cells and mainly basolaterally from Caco-2 cells. FEBS Letters. 1993;330(3):293-6.

Author

Vogel, L K ; Suske, G ; Beato, M ; Norén, Ove ; Sjöström, H. / Uteroglobin, an apically secreted protein of the uterine epithelium, is secreted non-polarized form MDCK cells and mainly basolaterally from Caco-2 cells. I: FEBS Letters. 1993 ; Bind 330, Nr. 3. s. 293-6.

Bibtex

@article{0410f390e30e11ddb5fc000ea68e967b,
title = "Uteroglobin, an apically secreted protein of the uterine epithelium, is secreted non-polarized form MDCK cells and mainly basolaterally from Caco-2 cells",
abstract = "A complete cDNA encoding rabbit uteroglobin was constructed and expressed in MDCK and Caco-2 cells. The MDCK cells secrete uteroglobin in approximately equal amounts to the apical and the basolateral side, whereas the Caco-2 cells secrete uteroglobin mainly to the basolateral side. Both MDCK and Caco-2 cells thus secrete uteroglobin in a non-sorted manner. It has, however, previously been shown that uteroglobin is secreted exclusively at the apical membrane in primary cell culture of endometrial epithelial cells [S.K. Mani et al. (1991) Endocrinology 128, 1563-1573]. This suggests that either the endometrial epithelium has an apical default pathway or recognises a sorting signal not recognised by MDCK cells and Caco-2 cells. Our data thus show that a soluble molecule can be secreted at the apical, the basolateral or both membranes depending on the cell type.",
author = "Vogel, {L K} and G Suske and M Beato and Ove Nor{\'e}n and H Sj{\"o}str{\"o}m",
note = "Keywords: Animals; Cells, Cultured; Cloning, Molecular; DNA; Dogs; Endometrium; Female; Kidney; Rabbits; Uteroglobin",
year = "1993",
language = "English",
volume = "330",
pages = "293--6",
journal = "F E B S Letters",
issn = "0014-5793",
publisher = "JohnWiley & Sons Ltd",
number = "3",

}

RIS

TY - JOUR

T1 - Uteroglobin, an apically secreted protein of the uterine epithelium, is secreted non-polarized form MDCK cells and mainly basolaterally from Caco-2 cells

AU - Vogel, L K

AU - Suske, G

AU - Beato, M

AU - Norén, Ove

AU - Sjöström, H

N1 - Keywords: Animals; Cells, Cultured; Cloning, Molecular; DNA; Dogs; Endometrium; Female; Kidney; Rabbits; Uteroglobin

PY - 1993

Y1 - 1993

N2 - A complete cDNA encoding rabbit uteroglobin was constructed and expressed in MDCK and Caco-2 cells. The MDCK cells secrete uteroglobin in approximately equal amounts to the apical and the basolateral side, whereas the Caco-2 cells secrete uteroglobin mainly to the basolateral side. Both MDCK and Caco-2 cells thus secrete uteroglobin in a non-sorted manner. It has, however, previously been shown that uteroglobin is secreted exclusively at the apical membrane in primary cell culture of endometrial epithelial cells [S.K. Mani et al. (1991) Endocrinology 128, 1563-1573]. This suggests that either the endometrial epithelium has an apical default pathway or recognises a sorting signal not recognised by MDCK cells and Caco-2 cells. Our data thus show that a soluble molecule can be secreted at the apical, the basolateral or both membranes depending on the cell type.

AB - A complete cDNA encoding rabbit uteroglobin was constructed and expressed in MDCK and Caco-2 cells. The MDCK cells secrete uteroglobin in approximately equal amounts to the apical and the basolateral side, whereas the Caco-2 cells secrete uteroglobin mainly to the basolateral side. Both MDCK and Caco-2 cells thus secrete uteroglobin in a non-sorted manner. It has, however, previously been shown that uteroglobin is secreted exclusively at the apical membrane in primary cell culture of endometrial epithelial cells [S.K. Mani et al. (1991) Endocrinology 128, 1563-1573]. This suggests that either the endometrial epithelium has an apical default pathway or recognises a sorting signal not recognised by MDCK cells and Caco-2 cells. Our data thus show that a soluble molecule can be secreted at the apical, the basolateral or both membranes depending on the cell type.

M3 - Journal article

C2 - 8375500

VL - 330

SP - 293

EP - 296

JO - F E B S Letters

JF - F E B S Letters

SN - 0014-5793

IS - 3

ER -

ID: 9747103