Unique splicing pattern of the TCF7L2 gene in human pancreatic islets

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Standard

Unique splicing pattern of the TCF7L2 gene in human pancreatic islets. / Osmark, P; Hansson, O; Jonsson, Anna Elisabet; Rönn, T; Groop, L; Renström, E.

I: Diabetologia, Bind 52, Nr. 5, 05.2009, s. 850-4.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Osmark, P, Hansson, O, Jonsson, AE, Rönn, T, Groop, L & Renström, E 2009, 'Unique splicing pattern of the TCF7L2 gene in human pancreatic islets', Diabetologia, bind 52, nr. 5, s. 850-4. https://doi.org/10.1007/s00125-009-1293-z

APA

Osmark, P., Hansson, O., Jonsson, A. E., Rönn, T., Groop, L., & Renström, E. (2009). Unique splicing pattern of the TCF7L2 gene in human pancreatic islets. Diabetologia, 52(5), 850-4. https://doi.org/10.1007/s00125-009-1293-z

Vancouver

Osmark P, Hansson O, Jonsson AE, Rönn T, Groop L, Renström E. Unique splicing pattern of the TCF7L2 gene in human pancreatic islets. Diabetologia. 2009 maj;52(5):850-4. https://doi.org/10.1007/s00125-009-1293-z

Author

Osmark, P ; Hansson, O ; Jonsson, Anna Elisabet ; Rönn, T ; Groop, L ; Renström, E. / Unique splicing pattern of the TCF7L2 gene in human pancreatic islets. I: Diabetologia. 2009 ; Bind 52, Nr. 5. s. 850-4.

Bibtex

@article{f210c2a7d6a84186945c1018ff87bfb2,
title = "Unique splicing pattern of the TCF7L2 gene in human pancreatic islets",
abstract = "Intronic variation in the TCF7L2 gene exhibits the strongest association to type 2 diabetes observed to date, but the mechanism whereby this genetic variation translates into altered biological function is largely unknown. A possible explanation is a genotype-dependent difference in the complex splicing pattern; however, this has not previously been characterised in pancreatic or insulin target tissues. Here, the detailed TCF7L2 splicing pattern in five human tissues is described and dependence on risk genotype explored.",
keywords = "Adipose Tissue, Adult, Aged, Alternative Splicing, Cadaver, Diabetes Mellitus, Type 2, Exons, Female, Genetic Variation, Humans, Islets of Langerhans, Lymphocytes, Male, Middle Aged, Muscle, Skeletal, RNA, Reference Values, Reverse Transcriptase Polymerase Chain Reaction, TCF Transcription Factors, Tissue Donors, Transcription Factor 7-Like 2 Protein, Transcription, Genetic",
author = "P Osmark and O Hansson and Jonsson, {Anna Elisabet} and T R{\"o}nn and L Groop and E Renstr{\"o}m",
year = "2009",
month = may,
doi = "10.1007/s00125-009-1293-z",
language = "English",
volume = "52",
pages = "850--4",
journal = "Diabetologia",
issn = "0012-186X",
publisher = "Springer",
number = "5",

}

RIS

TY - JOUR

T1 - Unique splicing pattern of the TCF7L2 gene in human pancreatic islets

AU - Osmark, P

AU - Hansson, O

AU - Jonsson, Anna Elisabet

AU - Rönn, T

AU - Groop, L

AU - Renström, E

PY - 2009/5

Y1 - 2009/5

N2 - Intronic variation in the TCF7L2 gene exhibits the strongest association to type 2 diabetes observed to date, but the mechanism whereby this genetic variation translates into altered biological function is largely unknown. A possible explanation is a genotype-dependent difference in the complex splicing pattern; however, this has not previously been characterised in pancreatic or insulin target tissues. Here, the detailed TCF7L2 splicing pattern in five human tissues is described and dependence on risk genotype explored.

AB - Intronic variation in the TCF7L2 gene exhibits the strongest association to type 2 diabetes observed to date, but the mechanism whereby this genetic variation translates into altered biological function is largely unknown. A possible explanation is a genotype-dependent difference in the complex splicing pattern; however, this has not previously been characterised in pancreatic or insulin target tissues. Here, the detailed TCF7L2 splicing pattern in five human tissues is described and dependence on risk genotype explored.

KW - Adipose Tissue

KW - Adult

KW - Aged

KW - Alternative Splicing

KW - Cadaver

KW - Diabetes Mellitus, Type 2

KW - Exons

KW - Female

KW - Genetic Variation

KW - Humans

KW - Islets of Langerhans

KW - Lymphocytes

KW - Male

KW - Middle Aged

KW - Muscle, Skeletal

KW - RNA

KW - Reference Values

KW - Reverse Transcriptase Polymerase Chain Reaction

KW - TCF Transcription Factors

KW - Tissue Donors

KW - Transcription Factor 7-Like 2 Protein

KW - Transcription, Genetic

U2 - 10.1007/s00125-009-1293-z

DO - 10.1007/s00125-009-1293-z

M3 - Journal article

C2 - 19247628

VL - 52

SP - 850

EP - 854

JO - Diabetologia

JF - Diabetologia

SN - 0012-186X

IS - 5

ER -

ID: 46404471