Ubiquitylation and degradation of elongating RNA polymerase II: the last resort
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Ubiquitylation and degradation of elongating RNA polymerase II : the last resort. / Wilson, Marcus D; Harreman, Michelle; Svejstrup, Jesper Q.
I: BBA Gene Regulatory Mechanisms, Bind 1829, Nr. 1, 01.2013, s. 151-7.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Ubiquitylation and degradation of elongating RNA polymerase II
T2 - the last resort
AU - Wilson, Marcus D
AU - Harreman, Michelle
AU - Svejstrup, Jesper Q
N1 - Copyright © 2012 Elsevier B.V. All rights reserved.
PY - 2013/1
Y1 - 2013/1
N2 - During its journey across a gene, RNA polymerase II has to contend with a number of obstacles to its progression, including nucleosomes, DNA-binding proteins, DNA damage, and sequences that are intrinsically difficult to transcribe. Not surprisingly, a large number of elongation factors have evolved to ensure that transcription stalling or arrest does not occur. If, however, the polymerase cannot be restarted, it becomes poly-ubiquitylated and degraded by the proteasome. This process is highly regulated, ensuring that only RNAPII molecules that cannot otherwise be salvaged are degraded. In this review, we describe the mechanisms and factors responsible for the last resort mechanism of transcriptional elongation. This article is part of a Special Issue entitled: RNA polymerase II Transcript Elongation.
AB - During its journey across a gene, RNA polymerase II has to contend with a number of obstacles to its progression, including nucleosomes, DNA-binding proteins, DNA damage, and sequences that are intrinsically difficult to transcribe. Not surprisingly, a large number of elongation factors have evolved to ensure that transcription stalling or arrest does not occur. If, however, the polymerase cannot be restarted, it becomes poly-ubiquitylated and degraded by the proteasome. This process is highly regulated, ensuring that only RNAPII molecules that cannot otherwise be salvaged are degraded. In this review, we describe the mechanisms and factors responsible for the last resort mechanism of transcriptional elongation. This article is part of a Special Issue entitled: RNA polymerase II Transcript Elongation.
KW - Animals
KW - DNA Damage
KW - DNA Repair
KW - Genomic Instability
KW - Humans
KW - Models, Biological
KW - Proteolysis
KW - RNA Polymerase II
KW - Transcription Elongation, Genetic
KW - Ubiquitination
U2 - 10.1016/j.bbagrm.2012.08.002
DO - 10.1016/j.bbagrm.2012.08.002
M3 - Journal article
C2 - 22960598
VL - 1829
SP - 151
EP - 157
JO - BBA Gene Regulatory Mechanisms
JF - BBA Gene Regulatory Mechanisms
SN - 1874-9399
IS - 1
ER -
ID: 47713381