Types I and III procollagen extension peptides in serum respond to fracture in humans

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Standard

Types I and III procollagen extension peptides in serum respond to fracture in humans. / Joerring, S; Jensen, L T; Andersen, G R; Johansen, J S.

I: Archives of Orthopaedic and Trauma Surgery, Bind 111, Nr. 5, 1992, s. 265-7.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Joerring, S, Jensen, LT, Andersen, GR & Johansen, JS 1992, 'Types I and III procollagen extension peptides in serum respond to fracture in humans', Archives of Orthopaedic and Trauma Surgery, bind 111, nr. 5, s. 265-7. https://doi.org/10.1007/BF00571521

APA

Joerring, S., Jensen, L. T., Andersen, G. R., & Johansen, J. S. (1992). Types I and III procollagen extension peptides in serum respond to fracture in humans. Archives of Orthopaedic and Trauma Surgery, 111(5), 265-7. https://doi.org/10.1007/BF00571521

Vancouver

Joerring S, Jensen LT, Andersen GR, Johansen JS. Types I and III procollagen extension peptides in serum respond to fracture in humans. Archives of Orthopaedic and Trauma Surgery. 1992;111(5):265-7. https://doi.org/10.1007/BF00571521

Author

Joerring, S ; Jensen, L T ; Andersen, G R ; Johansen, J S. / Types I and III procollagen extension peptides in serum respond to fracture in humans. I: Archives of Orthopaedic and Trauma Surgery. 1992 ; Bind 111, Nr. 5. s. 265-7.

Bibtex

@article{4a835303fc3946249e10244ba270026a,

title = "Types I and III procollagen extension peptides in serum respond to fracture in humans",

abstract = "Markers of types I and III collagen turnover were measured in serial blood samples in 16 patients with a Colles' fracture. The collagen markers were the carboxy-terminal extension peptide of type I procollagen (PICP) and the amino-terminal extension peptide of type III procollagen (PIIINP). Significant increases were found of PIIINP within 1 week and of PICP within 2 weeks. This sequential appearance of PIIINP and PICP was found to be in agreement with the appearance of types III and I collagen during early fracture healing as demonstrated in previous animal experimental studies. PICP had levelled off after 9 months, whereas PIIINP remained elevated. Osteocalcin, a serum marker of osteoblast activity, increased within 1 week and levelled off after 9 months. Correlations between the change in osteocalcin and those in PICP and PIIINP, respectively, were weak. These new biochemical markers may prove relevant as non-invasive markers of normal and pathological fracture healing in humans.",

keywords = "Adult, Aged, Aged, 80 and over, Colles' Fracture, Female, Humans, Male, Middle Aged, Osteocalcin, Peptide Fragments, Procollagen, Journal Article, Research Support, Non-U.S. Gov't",

author = "S Joerring and Jensen, {L T} and Andersen, {G R} and Johansen, {J S}",

year = "1992",

doi = "10.1007/BF00571521",

language = "English",

volume = "111",

pages = "265--7",

journal = "Archives of Orthopaedic and Trauma Surgery",

issn = "0936-8051",

publisher = "Springer",

number = "5",

}

RIS

TY - JOUR

T1 - Types I and III procollagen extension peptides in serum respond to fracture in humans

AU - Joerring, S

AU - Jensen, L T

AU - Andersen, G R

AU - Johansen, J S

PY - 1992

Y1 - 1992

N2 - Markers of types I and III collagen turnover were measured in serial blood samples in 16 patients with a Colles' fracture. The collagen markers were the carboxy-terminal extension peptide of type I procollagen (PICP) and the amino-terminal extension peptide of type III procollagen (PIIINP). Significant increases were found of PIIINP within 1 week and of PICP within 2 weeks. This sequential appearance of PIIINP and PICP was found to be in agreement with the appearance of types III and I collagen during early fracture healing as demonstrated in previous animal experimental studies. PICP had levelled off after 9 months, whereas PIIINP remained elevated. Osteocalcin, a serum marker of osteoblast activity, increased within 1 week and levelled off after 9 months. Correlations between the change in osteocalcin and those in PICP and PIIINP, respectively, were weak. These new biochemical markers may prove relevant as non-invasive markers of normal and pathological fracture healing in humans.

AB - Markers of types I and III collagen turnover were measured in serial blood samples in 16 patients with a Colles' fracture. The collagen markers were the carboxy-terminal extension peptide of type I procollagen (PICP) and the amino-terminal extension peptide of type III procollagen (PIIINP). Significant increases were found of PIIINP within 1 week and of PICP within 2 weeks. This sequential appearance of PIIINP and PICP was found to be in agreement with the appearance of types III and I collagen during early fracture healing as demonstrated in previous animal experimental studies. PICP had levelled off after 9 months, whereas PIIINP remained elevated. Osteocalcin, a serum marker of osteoblast activity, increased within 1 week and levelled off after 9 months. Correlations between the change in osteocalcin and those in PICP and PIIINP, respectively, were weak. These new biochemical markers may prove relevant as non-invasive markers of normal and pathological fracture healing in humans.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Colles' Fracture

KW - Female

KW - Humans

KW - Male

KW - Middle Aged

KW - Osteocalcin

KW - Peptide Fragments

KW - Procollagen

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1007/BF00571521

DO - 10.1007/BF00571521

M3 - Journal article

C2 - 1389778

VL - 111

SP - 265

EP - 267

JO - Archives of Orthopaedic and Trauma Surgery

JF - Archives of Orthopaedic and Trauma Surgery

SN - 0936-8051

IS - 5

ER -

ID: 168533374