Tuberculosis among HIV-positive patients across Europe: changes over time and risk factors
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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Tuberculosis among HIV-positive patients across Europe: changes over time and risk factors. / Kruk, Alexey; Bannister, Wendy; Podlekareva, Daria N; Chentsova, Nelly P; Rakhmanova, Aza G; Horban, Andrzej; Domingo, Perre; Mocroft, Amanda; Lundgren, Jens D; Kirk, Ole; on behalf of the EuroSIDA study group.
I: AIDS, Bind 25, Nr. 12, 31.07.2011, s. 1505-13.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Tuberculosis among HIV-positive patients across Europe: changes over time and risk factors
AU - Kruk, Alexey
AU - Bannister, Wendy
AU - Podlekareva, Daria N
AU - Chentsova, Nelly P
AU - Rakhmanova, Aza G
AU - Horban, Andrzej
AU - Domingo, Perre
AU - Mocroft, Amanda
AU - Lundgren, Jens D
AU - Kirk, Ole
AU - on behalf of the EuroSIDA study group
PY - 2011/7/31
Y1 - 2011/7/31
N2 - OBJECTIVE:: To describe temporal changes in the incidence rate of tuberculosis (TB) (pulmonary or extrapulmonary) among HIV-positive patients in western Europe and risk factors of TB across Europe. METHODS:: Poisson regression models were used to determine temporal changes in incidence rate of TB among 11¿952 patients from western Europe (1994-2010), and to assess risk factors for TB among 12¿673 patients from across Europe with follow-up after 2001. RESULTS:: Two hundred and seventy-seven TB events occurred during 84¿221 person-years of follow-up (PYFU) in western Europe. The incidence rate declined from 1.91 [95% confidence interval (CI) 1.51-2.37)] in 1994-1995 to 0.12 (0.07-0.21)/100 PYFU in 2002-2003, and remained stable thereafter. After January 2001, 159 TB events were diagnosed; 65 cases in western Europe and 94 cases in eastern Europe; resulting in incidence rates of 0.12 (0.09-0.14) and 0.65 (0.52-0.79)/100 PYFU, respectively. In multivariable analysis, incidence rate of TB was approximately four-fold higher in eastern Europe compared with western Europe [incidence rate ratio (IRR) 4.25 (2.78-6.49), P¿
AB - OBJECTIVE:: To describe temporal changes in the incidence rate of tuberculosis (TB) (pulmonary or extrapulmonary) among HIV-positive patients in western Europe and risk factors of TB across Europe. METHODS:: Poisson regression models were used to determine temporal changes in incidence rate of TB among 11¿952 patients from western Europe (1994-2010), and to assess risk factors for TB among 12¿673 patients from across Europe with follow-up after 2001. RESULTS:: Two hundred and seventy-seven TB events occurred during 84¿221 person-years of follow-up (PYFU) in western Europe. The incidence rate declined from 1.91 [95% confidence interval (CI) 1.51-2.37)] in 1994-1995 to 0.12 (0.07-0.21)/100 PYFU in 2002-2003, and remained stable thereafter. After January 2001, 159 TB events were diagnosed; 65 cases in western Europe and 94 cases in eastern Europe; resulting in incidence rates of 0.12 (0.09-0.14) and 0.65 (0.52-0.79)/100 PYFU, respectively. In multivariable analysis, incidence rate of TB was approximately four-fold higher in eastern Europe compared with western Europe [incidence rate ratio (IRR) 4.25 (2.78-6.49), P¿
U2 - 10.1097/QAD.0b013e328348fafd
DO - 10.1097/QAD.0b013e328348fafd
M3 - Journal article
C2 - 21610489
VL - 25
SP - 1505
EP - 1513
JO - AIDS
JF - AIDS
SN - 1350-2840
IS - 12
ER -
ID: 33864212