Tropical diseases and risk of hypertension in the Amazon Basin: a cross-sectional study
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Tropical diseases and risk of hypertension in the Amazon Basin : a cross-sectional study. / Holm, Anna Engell; Gomes, Laura Cordeiro; Lima, Karine O.; Wegener, Alma; Matos, Luan O.; Vieira, Isabelle V. M.; Kaagaard, Molly D.; Pareek, Manan; de Souza, Rodrigo Medeiros; Farias Marinho, Claudio Romero; Biering-Sorensen, Tor; Silvestre, Odilson M.; Brainin, Philip.
I: Journal of Human Hypertension, Bind 36, 2022, s. 1121–1127.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - Tropical diseases and risk of hypertension in the Amazon Basin
T2 - a cross-sectional study
AU - Holm, Anna Engell
AU - Gomes, Laura Cordeiro
AU - Lima, Karine O.
AU - Wegener, Alma
AU - Matos, Luan O.
AU - Vieira, Isabelle V. M.
AU - Kaagaard, Molly D.
AU - Pareek, Manan
AU - de Souza, Rodrigo Medeiros
AU - Farias Marinho, Claudio Romero
AU - Biering-Sorensen, Tor
AU - Silvestre, Odilson M.
AU - Brainin, Philip
PY - 2022
Y1 - 2022
N2 - Although infectious diseases have been associated with cardiovascular conditions, little is known about tropical disease burden and hypertension. We hypothesized that a history of tropical infections was associated with hypertension. We examined participants from outpatient clinics in the Amazon Basin who were interviewed about prior exposure to tropical diseases, including dengue, malaria hospitalization, and leishmaniasis. Hypertension was defined as a prior physician diagnosis of hypertension, treatment with anti-hypertensive medication, or a systolic blood pressure >= 140 mmHg and/or a diastolic blood pressure >= 90 mmHg. We used logistic regression models to examine the relationship between tropical infectious disease and hypertension. We included 556 participants (mean age 41 +/- 15 years, 61% women) of whom 214 (38%) had hypertension and 354 (64%) had a history of tropical infectious disease. The distribution of tropical diseases was: dengue 270 (76%), malaria hospitalization 104 (29%) and leishmaniasis 48 (14%). Any prior tropical infection was significantly associated with prevalent hypertension (odds ratio 1.76 [95% CI 1.22-2.54], P = 0.003) and the association remained significant after adjusting for age, sex, body mass index, diabetes, hypercholesterolemia, socioeconomic status, smoking, vegetable intake and serum creatinine. Persons with a history of >= 2 tropical infections (n = 64) had the greatest risk of hypertension (odds ratio 2.04 [95% CI 1.15-3.63], P = 0.015). In adjusted models, prior infection with dengue was associated with hypertension (P = 0.006), but no associations were found with malaria hospitalization (P = 0.39) or leishmaniasis (P = 0.98). In conclusion, a history of tropical infectious disease was associated with hypertension. This finding supports the idea that pathogen burden may be related to cardiovascular conditions.
AB - Although infectious diseases have been associated with cardiovascular conditions, little is known about tropical disease burden and hypertension. We hypothesized that a history of tropical infections was associated with hypertension. We examined participants from outpatient clinics in the Amazon Basin who were interviewed about prior exposure to tropical diseases, including dengue, malaria hospitalization, and leishmaniasis. Hypertension was defined as a prior physician diagnosis of hypertension, treatment with anti-hypertensive medication, or a systolic blood pressure >= 140 mmHg and/or a diastolic blood pressure >= 90 mmHg. We used logistic regression models to examine the relationship between tropical infectious disease and hypertension. We included 556 participants (mean age 41 +/- 15 years, 61% women) of whom 214 (38%) had hypertension and 354 (64%) had a history of tropical infectious disease. The distribution of tropical diseases was: dengue 270 (76%), malaria hospitalization 104 (29%) and leishmaniasis 48 (14%). Any prior tropical infection was significantly associated with prevalent hypertension (odds ratio 1.76 [95% CI 1.22-2.54], P = 0.003) and the association remained significant after adjusting for age, sex, body mass index, diabetes, hypercholesterolemia, socioeconomic status, smoking, vegetable intake and serum creatinine. Persons with a history of >= 2 tropical infections (n = 64) had the greatest risk of hypertension (odds ratio 2.04 [95% CI 1.15-3.63], P = 0.015). In adjusted models, prior infection with dengue was associated with hypertension (P = 0.006), but no associations were found with malaria hospitalization (P = 0.39) or leishmaniasis (P = 0.98). In conclusion, a history of tropical infectious disease was associated with hypertension. This finding supports the idea that pathogen burden may be related to cardiovascular conditions.
KW - PATHOGEN BURDEN
KW - CUTANEOUS LEISHMANIASIS
KW - INFECTIOUS BURDEN
KW - BLOOD-PRESSURE
KW - PROTECTION
KW - CYTOKINES
KW - MALARIA
KW - TRENDS
U2 - 10.1038/s41371-021-00633-1
DO - 10.1038/s41371-021-00633-1
M3 - Journal article
C2 - 34775497
VL - 36
SP - 1121
EP - 1127
JO - Journal of Human Hypertension
JF - Journal of Human Hypertension
SN - 0950-9240
ER -
ID: 285735311