Transcriptome changes in STSV2-infected Sulfolobus islandicus REY15A undergoing continuous CRISPR spacer acquisition

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Standard

Transcriptome changes in STSV2-infected Sulfolobus islandicus REY15A undergoing continuous CRISPR spacer acquisition. / León Sobrino, Carlos; Kot, W.P.; Garrett, Roger Antony.

I: Molecular Microbiology, Bind 99, Nr. 4, 2016, s. 719-728.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

León Sobrino, C, Kot, WP & Garrett, RA 2016, 'Transcriptome changes in STSV2-infected Sulfolobus islandicus REY15A undergoing continuous CRISPR spacer acquisition', Molecular Microbiology, bind 99, nr. 4, s. 719-728. https://doi.org/10.1111/mmi.13263

APA

León Sobrino, C., Kot, W. P., & Garrett, R. A. (2016). Transcriptome changes in STSV2-infected Sulfolobus islandicus REY15A undergoing continuous CRISPR spacer acquisition. Molecular Microbiology, 99(4), 719-728. https://doi.org/10.1111/mmi.13263

Vancouver

León Sobrino C, Kot WP, Garrett RA. Transcriptome changes in STSV2-infected Sulfolobus islandicus REY15A undergoing continuous CRISPR spacer acquisition. Molecular Microbiology. 2016;99(4):719-728. https://doi.org/10.1111/mmi.13263

Author

León Sobrino, Carlos ; Kot, W.P. ; Garrett, Roger Antony. / Transcriptome changes in STSV2-infected Sulfolobus islandicus REY15A undergoing continuous CRISPR spacer acquisition. I: Molecular Microbiology. 2016 ; Bind 99, Nr. 4. s. 719-728.

Bibtex

@article{5b38aa1cd0cf4e14893611aaf09f0e5e,
title = "Transcriptome changes in STSV2-infected Sulfolobus islandicus REY15A undergoing continuous CRISPR spacer acquisition",
abstract = "A transcriptome study was performed on Sulfolobus islandicus REY15A actively undergoing CRISPR spacer acquisition from the crenarchaeal monocaudavirus STSV2 in rich and basal media over a 6 day period. Spacer acquisition preceded strong host growth retardation, altered transcriptional activity of four different CRISPR-Cas modules and changes in viral copy numbers, and with significant differences in the two media. Transcript levels of proteins involved in the cell cycle were reduced, while those of DNA replication, DNA repair, transcriptional regulation, and some antitoxin-toxin pairs and transposases were unchanged or enhanced. Antisense RNAs were implicated in the transcriptional regulation of adaptation and interference modules of the type I-A CRISPR-Cas system and evidence was found for the occurrence of functional coordination between the single CRISPR-Cas adaptation module and the functionally diverse interference modules.",
author = "{Le{\'o}n Sobrino}, Carlos and W.P. Kot and Garrett, {Roger Antony}",
year = "2016",
doi = "10.1111/mmi.13263",
language = "English",
volume = "99",
pages = "719--728",
journal = "Molecular Microbiology",
issn = "0950-382X",
publisher = "Wiley-Blackwell",
number = "4",

}

RIS

TY - JOUR

T1 - Transcriptome changes in STSV2-infected Sulfolobus islandicus REY15A undergoing continuous CRISPR spacer acquisition

AU - León Sobrino, Carlos

AU - Kot, W.P.

AU - Garrett, Roger Antony

PY - 2016

Y1 - 2016

N2 - A transcriptome study was performed on Sulfolobus islandicus REY15A actively undergoing CRISPR spacer acquisition from the crenarchaeal monocaudavirus STSV2 in rich and basal media over a 6 day period. Spacer acquisition preceded strong host growth retardation, altered transcriptional activity of four different CRISPR-Cas modules and changes in viral copy numbers, and with significant differences in the two media. Transcript levels of proteins involved in the cell cycle were reduced, while those of DNA replication, DNA repair, transcriptional regulation, and some antitoxin-toxin pairs and transposases were unchanged or enhanced. Antisense RNAs were implicated in the transcriptional regulation of adaptation and interference modules of the type I-A CRISPR-Cas system and evidence was found for the occurrence of functional coordination between the single CRISPR-Cas adaptation module and the functionally diverse interference modules.

AB - A transcriptome study was performed on Sulfolobus islandicus REY15A actively undergoing CRISPR spacer acquisition from the crenarchaeal monocaudavirus STSV2 in rich and basal media over a 6 day period. Spacer acquisition preceded strong host growth retardation, altered transcriptional activity of four different CRISPR-Cas modules and changes in viral copy numbers, and with significant differences in the two media. Transcript levels of proteins involved in the cell cycle were reduced, while those of DNA replication, DNA repair, transcriptional regulation, and some antitoxin-toxin pairs and transposases were unchanged or enhanced. Antisense RNAs were implicated in the transcriptional regulation of adaptation and interference modules of the type I-A CRISPR-Cas system and evidence was found for the occurrence of functional coordination between the single CRISPR-Cas adaptation module and the functionally diverse interference modules.

U2 - 10.1111/mmi.13263

DO - 10.1111/mmi.13263

M3 - Journal article

C2 - 26514343

VL - 99

SP - 719

EP - 728

JO - Molecular Microbiology

JF - Molecular Microbiology

SN - 0950-382X

IS - 4

ER -

ID: 147507294