Transcription-replication conflicts at chromosomal fragile sites—consequences in M phase and beyond
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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Transcription-replication conflicts at chromosomal fragile sites—consequences in M phase and beyond. / Østergaard, Vibe Hallundbæk; Lisby, Michael.
I: Chromosoma, Bind 126, Nr. 2, 03.2017, s. 213-222.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - Transcription-replication conflicts at chromosomal fragile sites—consequences in M phase and beyond
AU - Østergaard, Vibe Hallundbæk
AU - Lisby, Michael
PY - 2017/3
Y1 - 2017/3
N2 - Collision between the molecular machineries responsible for transcription and replication is an important source of genome instability. Certain transcribed regions known as chromosomal fragile sites are particularly prone to recombine and mutate in a manner that correlates with specific transcription and replication patterns. At the same time, these chromosomal fragile sites engage in aberrant DNA structures in mitosis. Here, we discuss the mechanistic details of transcription–replication conflicts including putative scenarios for R-loop-induced replication inhibition to understand how transcription–replication conflicts transition from S phase into various aberrant DNA structures in mitosis.
AB - Collision between the molecular machineries responsible for transcription and replication is an important source of genome instability. Certain transcribed regions known as chromosomal fragile sites are particularly prone to recombine and mutate in a manner that correlates with specific transcription and replication patterns. At the same time, these chromosomal fragile sites engage in aberrant DNA structures in mitosis. Here, we discuss the mechanistic details of transcription–replication conflicts including putative scenarios for R-loop-induced replication inhibition to understand how transcription–replication conflicts transition from S phase into various aberrant DNA structures in mitosis.
KW - Anaphase bridges
KW - Chromosomal fragile sites
KW - Mitosis
KW - Replication
KW - Template switching
KW - Transcription
UR - http://www.scopus.com/inward/record.url?scp=84992740339&partnerID=8YFLogxK
U2 - 10.1007/s00412-016-0617-2
DO - 10.1007/s00412-016-0617-2
M3 - Review
C2 - 27796495
AN - SCOPUS:84992740339
VL - 126
SP - 213
EP - 222
JO - Chromosoma
JF - Chromosoma
SN - 0009-5915
IS - 2
ER -
ID: 174176586