Thyroid dysfunction and exudative age-related macular degeneration – A longitudinal nationwide registry-based cohort study

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Standard

Thyroid dysfunction and exudative age-related macular degeneration – A longitudinal nationwide registry-based cohort study. / Boulakh, Lena; Isaksen, Jonas L.; Poulsen, Henrik Enghusen; Faber, Jens; Heegaard, Steffen; Nygaard, Birte; Kanters, Jørgen Kim; Toft, Peter Bjerre; Udholm, Patricia Mortens; Bek, Toke; Hesgaard, Helena Buch; Ellervik, Christina.

I: Acta Ophthalmologica, 2024.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Boulakh, L, Isaksen, JL, Poulsen, HE, Faber, J, Heegaard, S, Nygaard, B, Kanters, JK, Toft, PB, Udholm, PM, Bek, T, Hesgaard, HB & Ellervik, C 2024, 'Thyroid dysfunction and exudative age-related macular degeneration – A longitudinal nationwide registry-based cohort study', Acta Ophthalmologica. https://doi.org/10.1111/aos.16705

APA

Boulakh, L., Isaksen, J. L., Poulsen, H. E., Faber, J., Heegaard, S., Nygaard, B., Kanters, J. K., Toft, P. B., Udholm, P. M., Bek, T., Hesgaard, H. B., & Ellervik, C. (2024). Thyroid dysfunction and exudative age-related macular degeneration – A longitudinal nationwide registry-based cohort study. Acta Ophthalmologica. https://doi.org/10.1111/aos.16705

Vancouver

Boulakh L, Isaksen JL, Poulsen HE, Faber J, Heegaard S, Nygaard B o.a. Thyroid dysfunction and exudative age-related macular degeneration – A longitudinal nationwide registry-based cohort study. Acta Ophthalmologica. 2024. https://doi.org/10.1111/aos.16705

Author

Boulakh, Lena ; Isaksen, Jonas L. ; Poulsen, Henrik Enghusen ; Faber, Jens ; Heegaard, Steffen ; Nygaard, Birte ; Kanters, Jørgen Kim ; Toft, Peter Bjerre ; Udholm, Patricia Mortens ; Bek, Toke ; Hesgaard, Helena Buch ; Ellervik, Christina. / Thyroid dysfunction and exudative age-related macular degeneration – A longitudinal nationwide registry-based cohort study. I: Acta Ophthalmologica. 2024.

Bibtex

@article{5af8438fd4f449a3aa0a939b18423eb1,

title = "Thyroid dysfunction and exudative age-related macular degeneration – A longitudinal nationwide registry-based cohort study",

abstract = "Purpose: The association between thyroid dysfunction and exudative age-related macular degeneration (AMD) is unknown. Methods: In this Danish longitudinal nationwide registry-based cohort study we included all Danish residents aged 50–100 between 2008 and 2018. Using the Danish national registries, we studied the association between thyroid dysfunction and exudative AMD. Thyroid dysfunction was classified as two consecutive redeemed prescriptions of thyroid hormones (hypothyroidism) or anti-thyroid medication (hyperthyroidism). Exudative AMD was classified as an ICD diagnosis of AMD and a code for anti-VEGF treatment. All patients are treated for exudative AMD in a hospital in Denmark, and we therefore have complete registration of this patient group. Results: We included 2 087 305 individuals, of which 1 072 567 (51.4%) were women; 59 318 (2.8%) had hypothyroidism, and 33 922 (1.6%) had hyperthyroidism. During a median follow-up of 11 years, 26 998 (1.3%) people developed exudative AMD. Hypothyroidism (adjusted hazard ratio [HR]: 1.17; 95% confidence interval [CI] 1.10–1.25; p < 0.001) and hyperthyroidism (HR: 1.23; 95% CI:1.13–1.34; p < 0.001) were both associated with the development of exudative AMD. The age-stratified analyses yielded similar results to the main analyses, except that the risks were exaggerated in the older part of the population. Conclusion: This is the first longitudinal nationwide study showing that both hypo- and hyperthyroidism are associated with an increased risk of exudative AMD. AMD is a quantitative problem in the population and our findings could have a public health impact. Further studies are needed to study the underlying mechanisms of the association.",

keywords = "AMD, exudative AMD, hyperthyroidism, hypothyroidism, systemic disease, thyroid disease, thyroid dysfunction",

author = "Lena Boulakh and Isaksen, {Jonas L.} and Poulsen, {Henrik Enghusen} and Jens Faber and Steffen Heegaard and Birte Nygaard and Kanters, {J{\o}rgen Kim} and Toft, {Peter Bjerre} and Udholm, {Patricia Mortens} and Toke Bek and Hesgaard, {Helena Buch} and Christina Ellervik",

note = "Publisher Copyright: {\textcopyright} 2024 The Authors. Acta Ophthalmologica published by John Wiley & Sons Ltd on behalf of Acta Ophthalmologica Scandinavica Foundation.",

year = "2024",

doi = "10.1111/aos.16705",

language = "English",

journal = "Acta Ophthalmologica",

issn = "1755-375X",

publisher = "Wiley-Blackwell",

}

RIS

TY - JOUR

T1 - Thyroid dysfunction and exudative age-related macular degeneration – A longitudinal nationwide registry-based cohort study

AU - Boulakh, Lena

AU - Isaksen, Jonas L.

AU - Poulsen, Henrik Enghusen

AU - Faber, Jens

AU - Heegaard, Steffen

AU - Nygaard, Birte

AU - Kanters, Jørgen Kim

AU - Toft, Peter Bjerre

AU - Udholm, Patricia Mortens

AU - Bek, Toke

AU - Hesgaard, Helena Buch

AU - Ellervik, Christina

PY - 2024

Y1 - 2024

N2 - Purpose: The association between thyroid dysfunction and exudative age-related macular degeneration (AMD) is unknown. Methods: In this Danish longitudinal nationwide registry-based cohort study we included all Danish residents aged 50–100 between 2008 and 2018. Using the Danish national registries, we studied the association between thyroid dysfunction and exudative AMD. Thyroid dysfunction was classified as two consecutive redeemed prescriptions of thyroid hormones (hypothyroidism) or anti-thyroid medication (hyperthyroidism). Exudative AMD was classified as an ICD diagnosis of AMD and a code for anti-VEGF treatment. All patients are treated for exudative AMD in a hospital in Denmark, and we therefore have complete registration of this patient group. Results: We included 2 087 305 individuals, of which 1 072 567 (51.4%) were women; 59 318 (2.8%) had hypothyroidism, and 33 922 (1.6%) had hyperthyroidism. During a median follow-up of 11 years, 26 998 (1.3%) people developed exudative AMD. Hypothyroidism (adjusted hazard ratio [HR]: 1.17; 95% confidence interval [CI] 1.10–1.25; p < 0.001) and hyperthyroidism (HR: 1.23; 95% CI:1.13–1.34; p < 0.001) were both associated with the development of exudative AMD. The age-stratified analyses yielded similar results to the main analyses, except that the risks were exaggerated in the older part of the population. Conclusion: This is the first longitudinal nationwide study showing that both hypo- and hyperthyroidism are associated with an increased risk of exudative AMD. AMD is a quantitative problem in the population and our findings could have a public health impact. Further studies are needed to study the underlying mechanisms of the association.

AB - Purpose: The association between thyroid dysfunction and exudative age-related macular degeneration (AMD) is unknown. Methods: In this Danish longitudinal nationwide registry-based cohort study we included all Danish residents aged 50–100 between 2008 and 2018. Using the Danish national registries, we studied the association between thyroid dysfunction and exudative AMD. Thyroid dysfunction was classified as two consecutive redeemed prescriptions of thyroid hormones (hypothyroidism) or anti-thyroid medication (hyperthyroidism). Exudative AMD was classified as an ICD diagnosis of AMD and a code for anti-VEGF treatment. All patients are treated for exudative AMD in a hospital in Denmark, and we therefore have complete registration of this patient group. Results: We included 2 087 305 individuals, of which 1 072 567 (51.4%) were women; 59 318 (2.8%) had hypothyroidism, and 33 922 (1.6%) had hyperthyroidism. During a median follow-up of 11 years, 26 998 (1.3%) people developed exudative AMD. Hypothyroidism (adjusted hazard ratio [HR]: 1.17; 95% confidence interval [CI] 1.10–1.25; p < 0.001) and hyperthyroidism (HR: 1.23; 95% CI:1.13–1.34; p < 0.001) were both associated with the development of exudative AMD. The age-stratified analyses yielded similar results to the main analyses, except that the risks were exaggerated in the older part of the population. Conclusion: This is the first longitudinal nationwide study showing that both hypo- and hyperthyroidism are associated with an increased risk of exudative AMD. AMD is a quantitative problem in the population and our findings could have a public health impact. Further studies are needed to study the underlying mechanisms of the association.

KW - AMD

KW - exudative AMD

KW - hyperthyroidism

KW - hypothyroidism

KW - systemic disease

KW - thyroid disease

KW - thyroid dysfunction

U2 - 10.1111/aos.16705

DO - 10.1111/aos.16705

M3 - Journal article

C2 - 38712900

AN - SCOPUS:85192148528

JO - Acta Ophthalmologica

JF - Acta Ophthalmologica

SN - 1755-375X

ER -

ID: 391631645