The value of hippocampal volume, shape, and texture for 11-year prediction of dementia: a population-based study
Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Standard
The value of hippocampal volume, shape, and texture for 11-year prediction of dementia : a population-based study. / Achterberg, Hakim C.; Sørensen, Lauge; Wolters, Frank J.; Niessen, Wiro J.; Vernooij, Meike W.; Ikram, M. Arfan; Nielsen, Mads; de Bruijne, Marleen.
I: Neurobiology of Aging, Bind 81, 2019, s. 58-66.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - The value of hippocampal volume, shape, and texture for 11-year prediction of dementia
T2 - a population-based study
AU - Achterberg, Hakim C.
AU - Sørensen, Lauge
AU - Wolters, Frank J.
AU - Niessen, Wiro J.
AU - Vernooij, Meike W.
AU - Ikram, M. Arfan
AU - Nielsen, Mads
AU - de Bruijne, Marleen
PY - 2019
Y1 - 2019
N2 - Hippocampal volume and shape are known magnetic resonance imaging biomarkers of neurodegeneration. Recently, hippocampal texture has been shown to improve prediction of dementia in patients with mild cognitive impairment, but it is unknown whether texture adds prognostic information beyond volume and shape and whether the predictive value extends to cognitively healthy individuals. Using 510 subjects from the Rotterdam Study, a prospective, population-based cohort study, we investigated if hippocampal volume, shape, texture, and their combination were predictive of dementia and determined how predictive performance varied with time to diagnosis and presence of early clinical symptoms of dementia. All features showed significant predictive performance with the area under the receiver operating characteristic curve ranging from 0.700 for texture alone to 0.788 for the combination of volume and texture. Although predictive performance extended to those without objective cognitive complaints or mild cognitive impairment, performance decreased with increasing follow-up time. We conclude that a combination of multiple hippocampal features on magnetic resonance imaging performs better in predicting dementia in the general population than any feature by itself.
AB - Hippocampal volume and shape are known magnetic resonance imaging biomarkers of neurodegeneration. Recently, hippocampal texture has been shown to improve prediction of dementia in patients with mild cognitive impairment, but it is unknown whether texture adds prognostic information beyond volume and shape and whether the predictive value extends to cognitively healthy individuals. Using 510 subjects from the Rotterdam Study, a prospective, population-based cohort study, we investigated if hippocampal volume, shape, texture, and their combination were predictive of dementia and determined how predictive performance varied with time to diagnosis and presence of early clinical symptoms of dementia. All features showed significant predictive performance with the area under the receiver operating characteristic curve ranging from 0.700 for texture alone to 0.788 for the combination of volume and texture. Although predictive performance extended to those without objective cognitive complaints or mild cognitive impairment, performance decreased with increasing follow-up time. We conclude that a combination of multiple hippocampal features on magnetic resonance imaging performs better in predicting dementia in the general population than any feature by itself.
KW - Dementia
KW - Hippocampal shape
KW - Hippocampal texture
KW - MRI
KW - Population-based
KW - Prediction
UR - http://www.scopus.com/inward/record.url?scp=85067598499&partnerID=8YFLogxK
U2 - 10.1016/j.neurobiolaging.2019.05.007
DO - 10.1016/j.neurobiolaging.2019.05.007
M3 - Journal article
C2 - 31247459
AN - SCOPUS:85067598499
VL - 81
SP - 58
EP - 66
JO - Neurobiology of Aging
JF - Neurobiology of Aging
SN - 0197-4580
ER -
ID: 223454795