The systemic exposure to inhaled beclometasone/formoterol pMDI with valved holding chamber is independent of age and body size

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Standard

The systemic exposure to inhaled beclometasone/formoterol pMDI with valved holding chamber is independent of age and body size. / Govoni, Mirco; Piccinno, Annalisa; Lucci, Germano; Poli, Gianluigi; Acerbi, Daniela; Baronio, Roberta; Singh, Dave; Kuna, Piotr; Chawes, Bo L K; Bisgaard, Hans.

I: Pulmonary Pharmacology and Therapeutics, Bind 30, 02.2015, s. 102-109.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Govoni, M, Piccinno, A, Lucci, G, Poli, G, Acerbi, D, Baronio, R, Singh, D, Kuna, P, Chawes, BLK & Bisgaard, H 2015, 'The systemic exposure to inhaled beclometasone/formoterol pMDI with valved holding chamber is independent of age and body size', Pulmonary Pharmacology and Therapeutics, bind 30, s. 102-109. https://doi.org/10.1016/j.pupt.2014.04.003

APA

Govoni, M., Piccinno, A., Lucci, G., Poli, G., Acerbi, D., Baronio, R., Singh, D., Kuna, P., Chawes, B. L. K., & Bisgaard, H. (2015). The systemic exposure to inhaled beclometasone/formoterol pMDI with valved holding chamber is independent of age and body size. Pulmonary Pharmacology and Therapeutics, 30, 102-109. https://doi.org/10.1016/j.pupt.2014.04.003

Vancouver

Govoni M, Piccinno A, Lucci G, Poli G, Acerbi D, Baronio R o.a. The systemic exposure to inhaled beclometasone/formoterol pMDI with valved holding chamber is independent of age and body size. Pulmonary Pharmacology and Therapeutics. 2015 feb.;30:102-109. https://doi.org/10.1016/j.pupt.2014.04.003

Author

Govoni, Mirco ; Piccinno, Annalisa ; Lucci, Germano ; Poli, Gianluigi ; Acerbi, Daniela ; Baronio, Roberta ; Singh, Dave ; Kuna, Piotr ; Chawes, Bo L K ; Bisgaard, Hans. / The systemic exposure to inhaled beclometasone/formoterol pMDI with valved holding chamber is independent of age and body size. I: Pulmonary Pharmacology and Therapeutics. 2015 ; Bind 30. s. 102-109.

Bibtex

@article{dcba465e898d4737b53c0e2e8883742b,

title = "The systemic exposure to inhaled beclometasone/formoterol pMDI with valved holding chamber is independent of age and body size",

abstract = "BACKGROUND: Asthma guidelines recommend prescription of inhaled corticosteroids at a reduced dosage in children compared to older patients in order to minimize the systemic exposure and risk of unwanted side effects. In children, pressurized metered dose inhalers (pMDI) are recommended in combination with a valved holding chamber (VHC) to overcome the problem of coordinating inhalation with actuation. However, the influence of age and body size on the systemic exposure of drugs to be administered via a pMDI with VHC is still not fully elucidated. Therefore, we aimed to compare the systemic exposure to the active ingredients of a fixed combination of beclometasone-dipropionate/formoterol-fumarate administered via pMDI with VHC in children, adolescents and adults.METHODS: The pharmacokinetics of formoterol and beclometasone-17-monopropionate (active metabolite of beclometasone-dipropionate) was evaluated over 8 h from three studies, each performed in a different age and body size group. Children (7-11 years, n = 20), adolescents (12-17 years, n = 29) and adults (≥18 years, n = 24) received a single dose of beclometasone/formoterol (children: 200 μg/24 μg, adolescents and adults: 400 μg/24 μg) via pMDI with AeroChamber Plus{\texttrademark}.RESULTS: The systemic exposure in children in comparison to adolescents was equivalent for formoterol while it was halved for beclometasone-17-monopropionate in accordance with the halved dose of beclometasone administered in children (90% CIs within 0.8-1.25 for formoterol and 0.4-0.625 for beclometasone-17-monopropionate). The systemic exposure to beclometasone-17-monopropionate and formoterol was equivalent between adolescents and adults.CONCLUSIONS: The systemic exposure to the active ingredients of a fixed dose combination of beclometasone/formoterol administered via pMDI with AeroChamber Plus{\texttrademark} correlates with the nominal dose independently of patient age and body size. Thus, dose reduction in relation to age when using a pMDI with VHC may be unnecessary for reducing the systemic exposure in children.",

author = "Mirco Govoni and Annalisa Piccinno and Germano Lucci and Gianluigi Poli and Daniela Acerbi and Roberta Baronio and Dave Singh and Piotr Kuna and Chawes, {Bo L K} and Hans Bisgaard",

year = "2015",

month = feb,

doi = "10.1016/j.pupt.2014.04.003",

language = "English",

volume = "30",

pages = "102--109",

journal = "Pulmonary Pharmacology and Therapeutics",

issn = "1094-5539",

publisher = "Academic Press",

}

RIS

TY - JOUR

T1 - The systemic exposure to inhaled beclometasone/formoterol pMDI with valved holding chamber is independent of age and body size

AU - Govoni, Mirco

AU - Piccinno, Annalisa

AU - Lucci, Germano

AU - Poli, Gianluigi

AU - Acerbi, Daniela

AU - Baronio, Roberta

AU - Singh, Dave

AU - Kuna, Piotr

AU - Chawes, Bo L K

AU - Bisgaard, Hans

PY - 2015/2

Y1 - 2015/2

N2 - BACKGROUND: Asthma guidelines recommend prescription of inhaled corticosteroids at a reduced dosage in children compared to older patients in order to minimize the systemic exposure and risk of unwanted side effects. In children, pressurized metered dose inhalers (pMDI) are recommended in combination with a valved holding chamber (VHC) to overcome the problem of coordinating inhalation with actuation. However, the influence of age and body size on the systemic exposure of drugs to be administered via a pMDI with VHC is still not fully elucidated. Therefore, we aimed to compare the systemic exposure to the active ingredients of a fixed combination of beclometasone-dipropionate/formoterol-fumarate administered via pMDI with VHC in children, adolescents and adults.METHODS: The pharmacokinetics of formoterol and beclometasone-17-monopropionate (active metabolite of beclometasone-dipropionate) was evaluated over 8 h from three studies, each performed in a different age and body size group. Children (7-11 years, n = 20), adolescents (12-17 years, n = 29) and adults (≥18 years, n = 24) received a single dose of beclometasone/formoterol (children: 200 μg/24 μg, adolescents and adults: 400 μg/24 μg) via pMDI with AeroChamber Plus™.RESULTS: The systemic exposure in children in comparison to adolescents was equivalent for formoterol while it was halved for beclometasone-17-monopropionate in accordance with the halved dose of beclometasone administered in children (90% CIs within 0.8-1.25 for formoterol and 0.4-0.625 for beclometasone-17-monopropionate). The systemic exposure to beclometasone-17-monopropionate and formoterol was equivalent between adolescents and adults.CONCLUSIONS: The systemic exposure to the active ingredients of a fixed dose combination of beclometasone/formoterol administered via pMDI with AeroChamber Plus™ correlates with the nominal dose independently of patient age and body size. Thus, dose reduction in relation to age when using a pMDI with VHC may be unnecessary for reducing the systemic exposure in children.

AB - BACKGROUND: Asthma guidelines recommend prescription of inhaled corticosteroids at a reduced dosage in children compared to older patients in order to minimize the systemic exposure and risk of unwanted side effects. In children, pressurized metered dose inhalers (pMDI) are recommended in combination with a valved holding chamber (VHC) to overcome the problem of coordinating inhalation with actuation. However, the influence of age and body size on the systemic exposure of drugs to be administered via a pMDI with VHC is still not fully elucidated. Therefore, we aimed to compare the systemic exposure to the active ingredients of a fixed combination of beclometasone-dipropionate/formoterol-fumarate administered via pMDI with VHC in children, adolescents and adults.METHODS: The pharmacokinetics of formoterol and beclometasone-17-monopropionate (active metabolite of beclometasone-dipropionate) was evaluated over 8 h from three studies, each performed in a different age and body size group. Children (7-11 years, n = 20), adolescents (12-17 years, n = 29) and adults (≥18 years, n = 24) received a single dose of beclometasone/formoterol (children: 200 μg/24 μg, adolescents and adults: 400 μg/24 μg) via pMDI with AeroChamber Plus™.RESULTS: The systemic exposure in children in comparison to adolescents was equivalent for formoterol while it was halved for beclometasone-17-monopropionate in accordance with the halved dose of beclometasone administered in children (90% CIs within 0.8-1.25 for formoterol and 0.4-0.625 for beclometasone-17-monopropionate). The systemic exposure to beclometasone-17-monopropionate and formoterol was equivalent between adolescents and adults.CONCLUSIONS: The systemic exposure to the active ingredients of a fixed dose combination of beclometasone/formoterol administered via pMDI with AeroChamber Plus™ correlates with the nominal dose independently of patient age and body size. Thus, dose reduction in relation to age when using a pMDI with VHC may be unnecessary for reducing the systemic exposure in children.

U2 - 10.1016/j.pupt.2014.04.003

DO - 10.1016/j.pupt.2014.04.003

M3 - Journal article

C2 - 24746942

VL - 30

SP - 102

EP - 109

JO - Pulmonary Pharmacology and Therapeutics

JF - Pulmonary Pharmacology and Therapeutics

SN - 1094-5539

ER -

ID: 138496017