The Skin Microbiome in Inflammatory Skin Diseases
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The Skin Microbiome in Inflammatory Skin Diseases. / Nørreslet, Line Brok; Agner, Tove; Clausen, Maja Lisa.
I: Current Dermatology Reports, Bind 9, Nr. 2, 2020, s. 141-151.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - The Skin Microbiome in Inflammatory Skin Diseases
AU - Nørreslet, Line Brok
AU - Agner, Tove
AU - Clausen, Maja Lisa
PY - 2020
Y1 - 2020
N2 - Purpose of Review: Ongoing investigations of the human skin microbiome strongly suggest a connection to skin diseases and skin health. This review provides an overview of recent literature on the skin microbiome in relation to skin diseases, with a specific focus on common inflammatory skin conditions, such as atopic dermatitis, psoriasis, hidradenitis suppurativa, acne, and rosacea. Recent Findings: In healthy subjects, the skin microbiome mediates fundamental processes involving the immune response and epidermal development and differentiation. Microbiome characteristics in inflammatory skin diseases differ depending on disease, as both topography and disease severity and even host genetics seem to influence the microbiome composition. Not only the bacterial species are important but also different strains within the same species can act differently, where some can be commensal and protect against microbial dysbiosis, whereas others can induce skin inflammation and immune reactions in humans. Summary: The interplay between skin microbes, host genetics, and the immune system is anticipated to be of importance for both the development and severity of many skin diseases. However, the causality of specific pathogens and the effect on the pathogenesis in relation to inflammatory skin diseases is yet to be understood.
AB - Purpose of Review: Ongoing investigations of the human skin microbiome strongly suggest a connection to skin diseases and skin health. This review provides an overview of recent literature on the skin microbiome in relation to skin diseases, with a specific focus on common inflammatory skin conditions, such as atopic dermatitis, psoriasis, hidradenitis suppurativa, acne, and rosacea. Recent Findings: In healthy subjects, the skin microbiome mediates fundamental processes involving the immune response and epidermal development and differentiation. Microbiome characteristics in inflammatory skin diseases differ depending on disease, as both topography and disease severity and even host genetics seem to influence the microbiome composition. Not only the bacterial species are important but also different strains within the same species can act differently, where some can be commensal and protect against microbial dysbiosis, whereas others can induce skin inflammation and immune reactions in humans. Summary: The interplay between skin microbes, host genetics, and the immune system is anticipated to be of importance for both the development and severity of many skin diseases. However, the causality of specific pathogens and the effect on the pathogenesis in relation to inflammatory skin diseases is yet to be understood.
KW - Atopic dermatitis
KW - Bacteria
KW - Dysbiosis
KW - Eczema
KW - Human skin microbiome
KW - Inflammatory skin disease
U2 - 10.1007/s13671-020-00297-z
DO - 10.1007/s13671-020-00297-z
M3 - Review
AN - SCOPUS:85083773172
VL - 9
SP - 141
EP - 151
JO - Current Dermatology Reports
JF - Current Dermatology Reports
SN - 2162-4933
IS - 2
ER -
ID: 260196218