TY - JOUR

T1 - The Skin Microbiome in Inflammatory Skin Diseases

AU - Nørreslet, Line Brok

AU - Agner, Tove

AU - Clausen, Maja Lisa

PY - 2020

Y1 - 2020

N2 - Purpose of Review: Ongoing investigations of the human skin microbiome strongly suggest a connection to skin diseases and skin health. This review provides an overview of recent literature on the skin microbiome in relation to skin diseases, with a specific focus on common inflammatory skin conditions, such as atopic dermatitis, psoriasis, hidradenitis suppurativa, acne, and rosacea. Recent Findings: In healthy subjects, the skin microbiome mediates fundamental processes involving the immune response and epidermal development and differentiation. Microbiome characteristics in inflammatory skin diseases differ depending on disease, as both topography and disease severity and even host genetics seem to influence the microbiome composition. Not only the bacterial species are important but also different strains within the same species can act differently, where some can be commensal and protect against microbial dysbiosis, whereas others can induce skin inflammation and immune reactions in humans. Summary: The interplay between skin microbes, host genetics, and the immune system is anticipated to be of importance for both the development and severity of many skin diseases. However, the causality of specific pathogens and the effect on the pathogenesis in relation to inflammatory skin diseases is yet to be understood.

AB - Purpose of Review: Ongoing investigations of the human skin microbiome strongly suggest a connection to skin diseases and skin health. This review provides an overview of recent literature on the skin microbiome in relation to skin diseases, with a specific focus on common inflammatory skin conditions, such as atopic dermatitis, psoriasis, hidradenitis suppurativa, acne, and rosacea. Recent Findings: In healthy subjects, the skin microbiome mediates fundamental processes involving the immune response and epidermal development and differentiation. Microbiome characteristics in inflammatory skin diseases differ depending on disease, as both topography and disease severity and even host genetics seem to influence the microbiome composition. Not only the bacterial species are important but also different strains within the same species can act differently, where some can be commensal and protect against microbial dysbiosis, whereas others can induce skin inflammation and immune reactions in humans. Summary: The interplay between skin microbes, host genetics, and the immune system is anticipated to be of importance for both the development and severity of many skin diseases. However, the causality of specific pathogens and the effect on the pathogenesis in relation to inflammatory skin diseases is yet to be understood.

KW - Atopic dermatitis

KW - Bacteria

KW - Dysbiosis

KW - Eczema

KW - Human skin microbiome

KW - Inflammatory skin disease

U2 - 10.1007/s13671-020-00297-z

DO - 10.1007/s13671-020-00297-z

M3 - Review

AN - SCOPUS:85083773172

VL - 9

SP - 141

EP - 151

JO - Current Dermatology Reports

JF - Current Dermatology Reports

SN - 2162-4933

IS - 2

ER -