The role of cytokines in migraine: A systematic review
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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The role of cytokines in migraine : A systematic review. / Thuraiaiyah, Janu; Erritzøe-Jervild, Mai; Al-Khazali, Haidar Muhsen; Schytz, Henrik Winther; Younis, Samaira.
I: Cephalalgia, Bind 42, Nr. 14, 2022, s. 1565-1588.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - The role of cytokines in migraine
T2 - A systematic review
AU - Thuraiaiyah, Janu
AU - Erritzøe-Jervild, Mai
AU - Al-Khazali, Haidar Muhsen
AU - Schytz, Henrik Winther
AU - Younis, Samaira
N1 - Publisher Copyright: © International Headache Society 2022.
PY - 2022
Y1 - 2022
N2 - Background: Cytokines are important endogenous substances that are involved in immune and inflammatory responses. Neurogenic inflammation has been proposed to play a role in migraine involving altered cytokine levels. Therefore, we aimed to provide a systematic review on the current knowledge on cytokine levels in migraine patients during and outside attacks. Methods: Databases of PubMed and Embase were systematically searched for studies investigating cytokine levels in migraine patients during and outside attacks. Results: Screening yielded identification of 45 articles investigating 18 cytokines in total. We found that the interictal level of the anti-inflammatory cytokine, interleukin 10, was decreased, while the level of transforming growth factor beta 1 was increased in migraine patients compared to controls. Levels of pro-inflammatory cytokines, tumor necrosis factor α and interleukin 6, were increased outside attacks compared to controls. Ictal levels of cytokines were unchanged or varying compared to the interictal state in migraine patients. Three studies reported dynamic cytokines levels during the course of an attack. Conclusion: The findings of the current review underline a possible involvement of cytokines in the proposed inflammatory mechanisms of migraine. However, future studies are needed to expand our knowledge of the exact role of cytokines in the migraine pathophysiology with focus on cytokines TNF-α, IL-1ß, IL-6 and IL-10 while applying refined methodology.
AB - Background: Cytokines are important endogenous substances that are involved in immune and inflammatory responses. Neurogenic inflammation has been proposed to play a role in migraine involving altered cytokine levels. Therefore, we aimed to provide a systematic review on the current knowledge on cytokine levels in migraine patients during and outside attacks. Methods: Databases of PubMed and Embase were systematically searched for studies investigating cytokine levels in migraine patients during and outside attacks. Results: Screening yielded identification of 45 articles investigating 18 cytokines in total. We found that the interictal level of the anti-inflammatory cytokine, interleukin 10, was decreased, while the level of transforming growth factor beta 1 was increased in migraine patients compared to controls. Levels of pro-inflammatory cytokines, tumor necrosis factor α and interleukin 6, were increased outside attacks compared to controls. Ictal levels of cytokines were unchanged or varying compared to the interictal state in migraine patients. Three studies reported dynamic cytokines levels during the course of an attack. Conclusion: The findings of the current review underline a possible involvement of cytokines in the proposed inflammatory mechanisms of migraine. However, future studies are needed to expand our knowledge of the exact role of cytokines in the migraine pathophysiology with focus on cytokines TNF-α, IL-1ß, IL-6 and IL-10 while applying refined methodology.
KW - chemokine
KW - cytokine
KW - Headache
KW - inflammation
KW - migraine
KW - pathophysiology
U2 - 10.1177/03331024221118924
DO - 10.1177/03331024221118924
M3 - Review
C2 - 35962530
AN - SCOPUS:85135956529
VL - 42
SP - 1565
EP - 1588
JO - Cephalalgia
JF - Cephalalgia
SN - 0800-1952
IS - 14
ER -
ID: 321646271