TY - CHAP

T1 - The Risk of Thromboembolism in Users of Antidepressants and Antipsychotics

AU - Adelborg, Kasper

AU - Sundbøll, Jens

AU - Videbech, Poul

AU - Grove, Erik L

PY - 2017

Y1 - 2017

N2 - Arterial and venous thromboembolism are common causes of morbidity and mortality in the Western world. Mental disorders are also highly prevalent with a lifetime risk of experiencing any psychiatric disease ranging between 32 % and 37 %. Depression and schizophrenia may increase the risk of thromboembolism through genetic, behavioral, and biological mechanisms. Treatment of psychiatric patients with psychotropic drugs is imperative to improve quality of life and to reduce morbidity and mortality. However, studies have shown that psychotropic drugs themselves may modify the risk of arterial and venous thromboembolism, which should be taken into consideration when using these drugs in clinical practice. This association is, however, multifactorial, complex and susceptible to several confounding factors. Psychotropic drugs are widely prescribed, also among patients with cardiovascular disease. Therefore, understanding the association with thromboembolism and the underlying pathophysiological mechanisms is of major importance and will be reviewed in this chapter.

AB - Arterial and venous thromboembolism are common causes of morbidity and mortality in the Western world. Mental disorders are also highly prevalent with a lifetime risk of experiencing any psychiatric disease ranging between 32 % and 37 %. Depression and schizophrenia may increase the risk of thromboembolism through genetic, behavioral, and biological mechanisms. Treatment of psychiatric patients with psychotropic drugs is imperative to improve quality of life and to reduce morbidity and mortality. However, studies have shown that psychotropic drugs themselves may modify the risk of arterial and venous thromboembolism, which should be taken into consideration when using these drugs in clinical practice. This association is, however, multifactorial, complex and susceptible to several confounding factors. Psychotropic drugs are widely prescribed, also among patients with cardiovascular disease. Therefore, understanding the association with thromboembolism and the underlying pathophysiological mechanisms is of major importance and will be reviewed in this chapter.

KW - Antidepressive Agents/administration & dosage

KW - Antipsychotic Agents/administration & dosage

KW - Depression/drug therapy

KW - Gastrointestinal Hemorrhage/chemically induced

KW - Humans

KW - Quality of Life

KW - Risk Factors

KW - Schizophrenia/drug therapy

KW - Serotonin Uptake Inhibitors/administration & dosage

KW - Thromboembolism/chemically induced

U2 - 10.1007/5584_2016_125

DO - 10.1007/5584_2016_125

M3 - Book chapter

C2 - 27638627

VL - 906

T3 - Advances in Experimental Medicine and Biology

SP - 351

EP - 361

BT - Thrombosis and Embolism: from Research to Clinical Practice

ER -