The R213G polymorphism in SOD3 protects against allergic airway inflammation

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The R213G polymorphism in SOD3 protects against allergic airway inflammation. / Gaurav, Rohit; Varasteh, Jason T; Weaver, Michael R; Jacobson, Sean R; Hernandez-Lagunas, Laura; Liu, Qing; Nozik-Grayck, Eva; Chu, Hong Wei; Alam, Rafeul; Nordestgaard, Børge G; Kobylecki, Camilla J; Afzal, Shoaib; Chupp, Geoffrey L; Bowler, Russell P.

I: JCI insight, Bind 2, Nr. 17, e95072, 2017.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Gaurav, R, Varasteh, JT, Weaver, MR, Jacobson, SR, Hernandez-Lagunas, L, Liu, Q, Nozik-Grayck, E, Chu, HW, Alam, R, Nordestgaard, BG, Kobylecki, CJ, Afzal, S, Chupp, GL & Bowler, RP 2017, 'The R213G polymorphism in SOD3 protects against allergic airway inflammation', JCI insight, bind 2, nr. 17, e95072. https://doi.org/10.1172/jci.insight.95072

APA

Gaurav, R., Varasteh, J. T., Weaver, M. R., Jacobson, S. R., Hernandez-Lagunas, L., Liu, Q., Nozik-Grayck, E., Chu, H. W., Alam, R., Nordestgaard, B. G., Kobylecki, C. J., Afzal, S., Chupp, G. L., & Bowler, R. P. (2017). The R213G polymorphism in SOD3 protects against allergic airway inflammation. JCI insight, 2(17), [e95072]. https://doi.org/10.1172/jci.insight.95072

Vancouver

Gaurav R, Varasteh JT, Weaver MR, Jacobson SR, Hernandez-Lagunas L, Liu Q o.a. The R213G polymorphism in SOD3 protects against allergic airway inflammation. JCI insight. 2017;2(17). e95072. https://doi.org/10.1172/jci.insight.95072

Author

Gaurav, Rohit ; Varasteh, Jason T ; Weaver, Michael R ; Jacobson, Sean R ; Hernandez-Lagunas, Laura ; Liu, Qing ; Nozik-Grayck, Eva ; Chu, Hong Wei ; Alam, Rafeul ; Nordestgaard, Børge G ; Kobylecki, Camilla J ; Afzal, Shoaib ; Chupp, Geoffrey L ; Bowler, Russell P. / The R213G polymorphism in SOD3 protects against allergic airway inflammation. I: JCI insight. 2017 ; Bind 2, Nr. 17.

Bibtex

@article{9d94417f0b4a49c3be407fe4aec26b1e,
title = "The R213G polymorphism in SOD3 protects against allergic airway inflammation",
abstract = "Oxidative stress is important in the pathogenesis of allergic asthma. Extracellular superoxide dismutase (EC-SOD; SOD3) is the major antioxidant in lungs, but its role in allergic asthma is unknown. Here we report that asthmatics have increased SOD3 transcript levels in sputum and that a single nucleotide polymorphism (SNP) in SOD3 (R213G; rs1799895) changes lung distribution of EC-SOD, and decreases likelihood of asthma-related symptoms. Knockin mice analogous to the human R213G SNP had lower airway hyperresponsiveness, inflammation, and mucus hypersecretion with decreased interleukin-33 (IL-33) in bronchoalveolar lavage fluid and reduced type II innate lymphoid cells (ILC2s) in lungs. SOD mimetic (Mn (III) tetrakis (N-ethylpyridinium-2-yl) porphyrin) attenuated Alternaria-induced expression of IL-33 and IL-8 release in BEAS-2B cells. These results suggest that R213G SNP potentially benefits its carriers by resulting in high EC-SOD in airway-lining fluid, which ameliorates allergic airway inflammation by dampening the innate immune response, including IL-33/ST2-mediated changes in ILC2s.",
keywords = "Journal Article",
author = "Rohit Gaurav and Varasteh, {Jason T} and Weaver, {Michael R} and Jacobson, {Sean R} and Laura Hernandez-Lagunas and Qing Liu and Eva Nozik-Grayck and Chu, {Hong Wei} and Rafeul Alam and Nordestgaard, {B{\o}rge G} and Kobylecki, {Camilla J} and Shoaib Afzal and Chupp, {Geoffrey L} and Bowler, {Russell P}",
year = "2017",
doi = "10.1172/jci.insight.95072",
language = "English",
volume = "2",
journal = "JCI Insight",
issn = "2379-3708",
publisher = "American Society for Clinical Investigation",
number = "17",

}

RIS

TY - JOUR

T1 - The R213G polymorphism in SOD3 protects against allergic airway inflammation

AU - Gaurav, Rohit

AU - Varasteh, Jason T

AU - Weaver, Michael R

AU - Jacobson, Sean R

AU - Hernandez-Lagunas, Laura

AU - Liu, Qing

AU - Nozik-Grayck, Eva

AU - Chu, Hong Wei

AU - Alam, Rafeul

AU - Nordestgaard, Børge G

AU - Kobylecki, Camilla J

AU - Afzal, Shoaib

AU - Chupp, Geoffrey L

AU - Bowler, Russell P

PY - 2017

Y1 - 2017

N2 - Oxidative stress is important in the pathogenesis of allergic asthma. Extracellular superoxide dismutase (EC-SOD; SOD3) is the major antioxidant in lungs, but its role in allergic asthma is unknown. Here we report that asthmatics have increased SOD3 transcript levels in sputum and that a single nucleotide polymorphism (SNP) in SOD3 (R213G; rs1799895) changes lung distribution of EC-SOD, and decreases likelihood of asthma-related symptoms. Knockin mice analogous to the human R213G SNP had lower airway hyperresponsiveness, inflammation, and mucus hypersecretion with decreased interleukin-33 (IL-33) in bronchoalveolar lavage fluid and reduced type II innate lymphoid cells (ILC2s) in lungs. SOD mimetic (Mn (III) tetrakis (N-ethylpyridinium-2-yl) porphyrin) attenuated Alternaria-induced expression of IL-33 and IL-8 release in BEAS-2B cells. These results suggest that R213G SNP potentially benefits its carriers by resulting in high EC-SOD in airway-lining fluid, which ameliorates allergic airway inflammation by dampening the innate immune response, including IL-33/ST2-mediated changes in ILC2s.

AB - Oxidative stress is important in the pathogenesis of allergic asthma. Extracellular superoxide dismutase (EC-SOD; SOD3) is the major antioxidant in lungs, but its role in allergic asthma is unknown. Here we report that asthmatics have increased SOD3 transcript levels in sputum and that a single nucleotide polymorphism (SNP) in SOD3 (R213G; rs1799895) changes lung distribution of EC-SOD, and decreases likelihood of asthma-related symptoms. Knockin mice analogous to the human R213G SNP had lower airway hyperresponsiveness, inflammation, and mucus hypersecretion with decreased interleukin-33 (IL-33) in bronchoalveolar lavage fluid and reduced type II innate lymphoid cells (ILC2s) in lungs. SOD mimetic (Mn (III) tetrakis (N-ethylpyridinium-2-yl) porphyrin) attenuated Alternaria-induced expression of IL-33 and IL-8 release in BEAS-2B cells. These results suggest that R213G SNP potentially benefits its carriers by resulting in high EC-SOD in airway-lining fluid, which ameliorates allergic airway inflammation by dampening the innate immune response, including IL-33/ST2-mediated changes in ILC2s.

KW - Journal Article

U2 - 10.1172/jci.insight.95072

DO - 10.1172/jci.insight.95072

M3 - Journal article

C2 - 28878123

VL - 2

JO - JCI Insight

JF - JCI Insight

SN - 2379-3708

IS - 17

M1 - e95072

ER -

ID: 185685027