TY - JOUR

T1 - The provisional OMERACT ultrasonography score for giant cell arteritis

AU - Dejaco, Christian

AU - Ponte, Cristina

AU - Monti, Sara

AU - Rozza, Davide

AU - Scirè, Carlo Alberto

AU - Terslev, Lene

AU - Bruyn, George A.W.

AU - Boumans, Dennis

AU - Hartung, Wolfgang

AU - Hočevar, Alojzija

AU - Milchert, Marcin

AU - Døhn, Uffe Møller

AU - Mukhtyar, Chetan B.

AU - Aschwanden, Markus

AU - Bosch, Philipp

AU - Camellino, Dario

AU - Chrysidis, Stavros

AU - Ciancio, Giovanni

AU - D'Agostino, Maria Antonietta

AU - Daikeler, Thomas

AU - Dasgupta, Bhaskar

AU - De Miguel, Eugenio

AU - Diamantopoulos, Andreas P.

AU - Duftner, Christina

AU - Agueda, Ana

AU - Fredberg, Ulrich

AU - Hanova, Petra

AU - Hansen, Ib Tønder

AU - Hauge, Ellen Margrethe

AU - Iagnocco, Annamaria

AU - Inanc, Nevsun

AU - Juche, Aaron

AU - Karalilova, Rositsa

AU - Kawamoto, Toshio

AU - Keller, Kresten Krarup

AU - Keen, Helen Isobel

AU - Kermani, Tanaz A.

AU - Kohler, Minna J.

AU - Koster, Matthew

AU - Luqmani, Raashid Ahmed

AU - MacChioni, Pierluigi

AU - MacKie, Sarah Louise

AU - Naredo, Esperanza

AU - Nielsen, Berit Dalsgaard

AU - Ogasawara, Michihiro

AU - Pineda, Carlos

AU - Schäfer, Valentin Sebastian

AU - Seitz, Luca

AU - Tomelleri, Alessandro

AU - Torralba, Karina D.

AU - Van Der Geest, Kornelis S.M.

AU - Warrington, Kenneth J.

AU - Schmidt, Wolfgang A.

N1 - Publisher Copyright: © Author(s) (or their employer(s)) 2022. No commercial re-use. See rights and permissions. Published by BMJ.

PY - 2023

Y1 - 2023

N2 - Objectives: To develop an Outcome Measures in Rheumatology (OMERACT) ultrasonography score for monitoring disease activity in giant cell arteritis (GCA) and evaluate its metric properties. Methods: The OMERACT Instrument Selection Algorithm was followed. Forty-nine members of the OMERACT ultrasonography large vessel vasculitis working group were invited to seven Delphi rounds. An online reliability exercise was conducted using images of bilateral common temporal arteries, parietal and frontal branches as well as axillary arteries from 16 patients with GCA and 7 controls. Sensitivity to change and convergent construct validity were tested using data from a prospective cohort of patients with new GCA in which ultrasound-based intima-media thickness (IMT) measurements were conducted at weeks 1, 3, 6, 12 and 24. Results: Agreement was obtained (92.7%) for the OMERACT GCA Ultrasonography Score (OGUS), calculated as follows: sum of IMT measured in every segment divided by the rounded cut-off values of IMTs in each segment. The resulting value is then divided by the number of segments available. Thirty-five members conducted the reliability exercise, the interrater intraclass correlation coefficient (ICC) for the OGUS was 0.72-0.84 and the median intrareader ICC was 0.91. The prospective cohort consisted of 52 patients. Sensitivity to change between baseline and each follow-up visit up to week 24 yielded standardised mean differences from-1.19 to-2.16, corresponding to large and very large magnitudes of change, respectively. OGUS correlated moderately with erythrocyte sedimentation rate, C reactive protein and Birmingham Vasculitis Activity Score (corrcoeff 0.37-0.48). Conclusion: We developed a provisional OGUS for potential use in clinical trials.

AB - Objectives: To develop an Outcome Measures in Rheumatology (OMERACT) ultrasonography score for monitoring disease activity in giant cell arteritis (GCA) and evaluate its metric properties. Methods: The OMERACT Instrument Selection Algorithm was followed. Forty-nine members of the OMERACT ultrasonography large vessel vasculitis working group were invited to seven Delphi rounds. An online reliability exercise was conducted using images of bilateral common temporal arteries, parietal and frontal branches as well as axillary arteries from 16 patients with GCA and 7 controls. Sensitivity to change and convergent construct validity were tested using data from a prospective cohort of patients with new GCA in which ultrasound-based intima-media thickness (IMT) measurements were conducted at weeks 1, 3, 6, 12 and 24. Results: Agreement was obtained (92.7%) for the OMERACT GCA Ultrasonography Score (OGUS), calculated as follows: sum of IMT measured in every segment divided by the rounded cut-off values of IMTs in each segment. The resulting value is then divided by the number of segments available. Thirty-five members conducted the reliability exercise, the interrater intraclass correlation coefficient (ICC) for the OGUS was 0.72-0.84 and the median intrareader ICC was 0.91. The prospective cohort consisted of 52 patients. Sensitivity to change between baseline and each follow-up visit up to week 24 yielded standardised mean differences from-1.19 to-2.16, corresponding to large and very large magnitudes of change, respectively. OGUS correlated moderately with erythrocyte sedimentation rate, C reactive protein and Birmingham Vasculitis Activity Score (corrcoeff 0.37-0.48). Conclusion: We developed a provisional OGUS for potential use in clinical trials.

KW - giant cell arteritis

KW - outcome assessment, health care

KW - systemic vasculitis

KW - ultrasonography

U2 - 10.1136/ard-2022-223367

DO - 10.1136/ard-2022-223367

M3 - Journal article

C2 - 36600183

AN - SCOPUS:85144887883

VL - 82

SP - 556

EP - 564

JO - Annals of the Rheumatic Diseases

JF - Annals of the Rheumatic Diseases

SN - 0003-4967

IS - 4

ER -