The prevalence and prognostic value of concomitant eosinophilia in chronic graft-versus-host disease after allogeneic stem cell transplantation

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Standard

The prevalence and prognostic value of concomitant eosinophilia in chronic graft-versus-host disease after allogeneic stem cell transplantation. / Mortensen, Katrine Brandt; Gerds, Thomas Alexander; Bjerrum, Ole Weis; Lindmark, Anders; Sengeløv, Henrik; Andersen, Christen Lykkegaard.

I: Leukemia Research, Bind 38, Nr. 3, 03.2014, s. 334-9.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Mortensen, KB, Gerds, TA, Bjerrum, OW, Lindmark, A, Sengeløv, H & Andersen, CL 2014, 'The prevalence and prognostic value of concomitant eosinophilia in chronic graft-versus-host disease after allogeneic stem cell transplantation', Leukemia Research, bind 38, nr. 3, s. 334-9. https://doi.org/10.1016/j.leukres.2013.12.009

APA

Mortensen, K. B., Gerds, T. A., Bjerrum, O. W., Lindmark, A., Sengeløv, H., & Andersen, C. L. (2014). The prevalence and prognostic value of concomitant eosinophilia in chronic graft-versus-host disease after allogeneic stem cell transplantation. Leukemia Research, 38(3), 334-9. https://doi.org/10.1016/j.leukres.2013.12.009

Vancouver

Mortensen KB, Gerds TA, Bjerrum OW, Lindmark A, Sengeløv H, Andersen CL. The prevalence and prognostic value of concomitant eosinophilia in chronic graft-versus-host disease after allogeneic stem cell transplantation. Leukemia Research. 2014 mar.;38(3):334-9. https://doi.org/10.1016/j.leukres.2013.12.009

Author

Mortensen, Katrine Brandt ; Gerds, Thomas Alexander ; Bjerrum, Ole Weis ; Lindmark, Anders ; Sengeløv, Henrik ; Andersen, Christen Lykkegaard. / The prevalence and prognostic value of concomitant eosinophilia in chronic graft-versus-host disease after allogeneic stem cell transplantation. I: Leukemia Research. 2014 ; Bind 38, Nr. 3. s. 334-9.

Bibtex

@article{9cecd53ddedc4f84927028bdd5c620c4,

title = "The prevalence and prognostic value of concomitant eosinophilia in chronic graft-versus-host disease after allogeneic stem cell transplantation",

abstract = "The prognostic significance of eosinophilia after myeloablative allogeneic stem cell transplantation (ASCT) remains to be established. Patients, whom developed chronic graft-versus-host disease (cGVHD) after ASCT, were included (n = 142). Eosinophil count was analyzed at cGVHD onset. We observed no significant association between EO and the grade of cGVHD, thrombocytopenia, nor extensive skin involvement. Importantly, we observed no significant association between cGVHD with concomitant eosinophilia and long-term clinical outcomes, and subgroup analyses revealed a considerable confounding effect of ongoing steroid treatment. In conclusion, we advocate that prognostic conclusions regarding cGVHD with concomitant eosinophilia after ASCT should be interpreted with caution.",

keywords = "Adolescent, Adult, Blood Platelets, Eosinophilia, Eosinophils, Female, Glucocorticoids, Graft vs Host Disease, Hematopoietic Stem Cell Transplantation, Humans, Leukemia, Male, Middle Aged, Myeloablative Agonists, Prognosis, Risk Factors, Skin, Transplantation, Homologous",

author = "Mortensen, {Katrine Brandt} and Gerds, {Thomas Alexander} and Bjerrum, {Ole Weis} and Anders Lindmark and Henrik Sengel{\o}v and Andersen, {Christen Lykkegaard}",

year = "2014",

month = mar,

doi = "10.1016/j.leukres.2013.12.009",

language = "English",

volume = "38",

pages = "334--9",

journal = "Leukemia Research",

issn = "0145-2126",

publisher = "Pergamon Press",

number = "3",

}

RIS

TY - JOUR

T1 - The prevalence and prognostic value of concomitant eosinophilia in chronic graft-versus-host disease after allogeneic stem cell transplantation

AU - Mortensen, Katrine Brandt

AU - Gerds, Thomas Alexander

AU - Bjerrum, Ole Weis

AU - Lindmark, Anders

AU - Sengeløv, Henrik

AU - Andersen, Christen Lykkegaard

PY - 2014/3

Y1 - 2014/3

N2 - The prognostic significance of eosinophilia after myeloablative allogeneic stem cell transplantation (ASCT) remains to be established. Patients, whom developed chronic graft-versus-host disease (cGVHD) after ASCT, were included (n = 142). Eosinophil count was analyzed at cGVHD onset. We observed no significant association between EO and the grade of cGVHD, thrombocytopenia, nor extensive skin involvement. Importantly, we observed no significant association between cGVHD with concomitant eosinophilia and long-term clinical outcomes, and subgroup analyses revealed a considerable confounding effect of ongoing steroid treatment. In conclusion, we advocate that prognostic conclusions regarding cGVHD with concomitant eosinophilia after ASCT should be interpreted with caution.

AB - The prognostic significance of eosinophilia after myeloablative allogeneic stem cell transplantation (ASCT) remains to be established. Patients, whom developed chronic graft-versus-host disease (cGVHD) after ASCT, were included (n = 142). Eosinophil count was analyzed at cGVHD onset. We observed no significant association between EO and the grade of cGVHD, thrombocytopenia, nor extensive skin involvement. Importantly, we observed no significant association between cGVHD with concomitant eosinophilia and long-term clinical outcomes, and subgroup analyses revealed a considerable confounding effect of ongoing steroid treatment. In conclusion, we advocate that prognostic conclusions regarding cGVHD with concomitant eosinophilia after ASCT should be interpreted with caution.

KW - Adolescent

KW - Adult

KW - Blood Platelets

KW - Eosinophilia

KW - Eosinophils

KW - Female

KW - Glucocorticoids

KW - Graft vs Host Disease

KW - Hematopoietic Stem Cell Transplantation

KW - Humans

KW - Leukemia

KW - Male

KW - Middle Aged

KW - Myeloablative Agonists

KW - Prognosis

KW - Risk Factors

KW - Skin

KW - Transplantation, Homologous

U2 - 10.1016/j.leukres.2013.12.009

DO - 10.1016/j.leukres.2013.12.009

M3 - Journal article

C2 - 24439053

VL - 38

SP - 334

EP - 339

JO - Leukemia Research

JF - Leukemia Research

SN - 0145-2126

IS - 3

ER -

ID: 134781183