The precise ovarian volume is significantly associated with serum concentrations of antimüllerian hormone, the luteinizing hormone/follicle-stimulating hormone ratio, and total testosterone
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The precise ovarian volume is significantly associated with serum concentrations of antimüllerian hormone, the luteinizing hormone/follicle-stimulating hormone ratio, and total testosterone. / Wakimoto, Yu; Pors, Susanne Elisabeth; Cadenas, Jesús; Colmorn, Lotte; Ernst, Erik; Dueholm, Margit; Fedder, Jens; Mamsen, Linn S.; Kristensen, Stine Gry; Andersen, Claus Yding.
I: Fertility and Sterility, Bind 113, Nr. 2, 2020, s. 453-459.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - The precise ovarian volume is significantly associated with serum concentrations of antimüllerian hormone, the luteinizing hormone/follicle-stimulating hormone ratio, and total testosterone
AU - Wakimoto, Yu
AU - Pors, Susanne Elisabeth
AU - Cadenas, Jesús
AU - Colmorn, Lotte
AU - Ernst, Erik
AU - Dueholm, Margit
AU - Fedder, Jens
AU - Mamsen, Linn S.
AU - Kristensen, Stine Gry
AU - Andersen, Claus Yding
PY - 2020
Y1 - 2020
N2 - Objective: To evaluate potential associations between concentrations of antimüllerian hormone (AMH) and T as well as the LH/FSH ratio and the unbiased precise ovarian volume obtained after unilateral ovariectomy. Design: Cohort study. Setting: University hospital. Patient(s): A total of 765 patients having one ovary surgically removed for fertility preservation. Inclusion criteria were age >15 years and ovarian volume <25 mL; 386 women had one or more hormone parameter (AMH, LH, FSH, or total T) determined before oophorectomy. Intervention(s): None. Main Outcome Measure(s): A precise weight of the ovary was equated with ovarian volume. Associations between ovarian volume and AMH, the LH/FSH ratio, T concentrations, and body mass index (BMI) were evaluated. Patient characteristics in relation to ovarian volume cutoff values between 8 and 12 mL were also examined. Result(s): Ovarian volume was significantly positively associated with concentrations of AMH, the LH/FSH ratio, and T. Ovarian volume, concentrations of AMH and LH, and the LH/FSH ratio were significantly augmented in women having ovarian volumes above a threshold of 8, 9, and 10 mL compared with those below. Average age, FSH, and T concentrations did not differ between below and above the 10 mL threshold. There was a significant association between BMI and ovarian volume and BMI and T, while other hormone parameters were nonsignificant. Conclusion(s): The precise ovarian volume reflected ovarian activity measured as circulating concentrations of AMH and T as well as the LH/FSH ratio. These significant associations showed continuous progression, and a 10 mL threshold offered no clear difference compared with other volume threshold values.
AB - Objective: To evaluate potential associations between concentrations of antimüllerian hormone (AMH) and T as well as the LH/FSH ratio and the unbiased precise ovarian volume obtained after unilateral ovariectomy. Design: Cohort study. Setting: University hospital. Patient(s): A total of 765 patients having one ovary surgically removed for fertility preservation. Inclusion criteria were age >15 years and ovarian volume <25 mL; 386 women had one or more hormone parameter (AMH, LH, FSH, or total T) determined before oophorectomy. Intervention(s): None. Main Outcome Measure(s): A precise weight of the ovary was equated with ovarian volume. Associations between ovarian volume and AMH, the LH/FSH ratio, T concentrations, and body mass index (BMI) were evaluated. Patient characteristics in relation to ovarian volume cutoff values between 8 and 12 mL were also examined. Result(s): Ovarian volume was significantly positively associated with concentrations of AMH, the LH/FSH ratio, and T. Ovarian volume, concentrations of AMH and LH, and the LH/FSH ratio were significantly augmented in women having ovarian volumes above a threshold of 8, 9, and 10 mL compared with those below. Average age, FSH, and T concentrations did not differ between below and above the 10 mL threshold. There was a significant association between BMI and ovarian volume and BMI and T, while other hormone parameters were nonsignificant. Conclusion(s): The precise ovarian volume reflected ovarian activity measured as circulating concentrations of AMH and T as well as the LH/FSH ratio. These significant associations showed continuous progression, and a 10 mL threshold offered no clear difference compared with other volume threshold values.
KW - antimüllerian hormone
KW - LH/FSH ratio
KW - ovarian tissue cryopreservation
KW - Precise ovarian volume
KW - total testosterone
UR - http://www.scopus.com/inward/record.url?scp=85079854754&partnerID=8YFLogxK
U2 - 10.1016/j.fertnstert.2019.09.029
DO - 10.1016/j.fertnstert.2019.09.029
M3 - Journal article
C2 - 32106996
AN - SCOPUS:85079854754
VL - 113
SP - 453
EP - 459
JO - Sexuality, Reproduction and Menopause
JF - Sexuality, Reproduction and Menopause
SN - 1546-2501
IS - 2
ER -
ID: 255351090