The pathway for oxygen in brain
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The pathway for oxygen in brain. / Gjedde, Albert.
I: APMIS : Acta pathologica, microbiologica et immunologica Scandinavica. Supplementum, Nr. 109, 2003, s. 146-53.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - The pathway for oxygen in brain
AU - Gjedde, Albert
PY - 2003
Y1 - 2003
N2 - Blood-brain transfer of oxygen is a fundamental function of regional oxygen consumption. This function yielded a novel description of the mechanism of flow-metabolism coupling. The description revealed that constant oxygen consumption is not maintained by saturation of cytochrome oxidase but by adjustment of the enzyme's affinity towards oxygen. Interactions of oxygen and a factor that could be nitric oxide, at both cytochrome oxidase and nitric oxide synthase, match the affinities of both enzymes towards their respective substrates to the oxygen requirement of the tissue and, in doing so, explain several properties of flow-metabolism coupling.
AB - Blood-brain transfer of oxygen is a fundamental function of regional oxygen consumption. This function yielded a novel description of the mechanism of flow-metabolism coupling. The description revealed that constant oxygen consumption is not maintained by saturation of cytochrome oxidase but by adjustment of the enzyme's affinity towards oxygen. Interactions of oxygen and a factor that could be nitric oxide, at both cytochrome oxidase and nitric oxide synthase, match the affinities of both enzymes towards their respective substrates to the oxygen requirement of the tissue and, in doing so, explain several properties of flow-metabolism coupling.
M3 - Journal article
C2 - 12874967
SP - 146
EP - 153
JO - APMIS. Supplementum
JF - APMIS. Supplementum
SN - 0903-465X
IS - 109
ER -
ID: 14946647