The Mammalian Cysteine Protease Legumain in Health and Disease
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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The Mammalian Cysteine Protease Legumain in Health and Disease. / Solberg, Rigmor; Lunde, Ngoc Nguyen; Forbord, Karl Martin; Okla, Meshail; Kassem, Moustapha; Jafari, Abbas.
I: International Journal of Molecular Sciences, Bind 23, Nr. 24, 15983, 2022.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - The Mammalian Cysteine Protease Legumain in Health and Disease
AU - Solberg, Rigmor
AU - Lunde, Ngoc Nguyen
AU - Forbord, Karl Martin
AU - Okla, Meshail
AU - Kassem, Moustapha
AU - Jafari, Abbas
N1 - Publisher Copyright: © 2022 by the authors.
PY - 2022
Y1 - 2022
N2 - The cysteine protease legumain (also known as asparaginyl endopeptidase or δ-secretase) is the only known mammalian asparaginyl endopeptidase and is primarily localized to the endolysosomal system, although it is also found extracellularly as a secreted protein. Legumain is involved in the regulation of diverse biological processes and tissue homeostasis, and in the pathogenesis of various malignant and nonmalignant diseases. In addition to its proteolytic activity that leads to the degradation or activation of different substrates, legumain has also been shown to have a nonproteolytic ligase function. This review summarizes the current knowledge about legumain functions in health and disease, including kidney homeostasis, hematopoietic homeostasis, bone remodeling, cardiovascular and cerebrovascular diseases, fibrosis, aging and senescence, neurodegenerative diseases and cancer. In addition, this review addresses the effects of some marketed drugs on legumain. Expanding our knowledge on legumain will delineate the importance of this enzyme in regulating physiological processes and disease conditions.
AB - The cysteine protease legumain (also known as asparaginyl endopeptidase or δ-secretase) is the only known mammalian asparaginyl endopeptidase and is primarily localized to the endolysosomal system, although it is also found extracellularly as a secreted protein. Legumain is involved in the regulation of diverse biological processes and tissue homeostasis, and in the pathogenesis of various malignant and nonmalignant diseases. In addition to its proteolytic activity that leads to the degradation or activation of different substrates, legumain has also been shown to have a nonproteolytic ligase function. This review summarizes the current knowledge about legumain functions in health and disease, including kidney homeostasis, hematopoietic homeostasis, bone remodeling, cardiovascular and cerebrovascular diseases, fibrosis, aging and senescence, neurodegenerative diseases and cancer. In addition, this review addresses the effects of some marketed drugs on legumain. Expanding our knowledge on legumain will delineate the importance of this enzyme in regulating physiological processes and disease conditions.
KW - asaparginyl endopeptidae (AEP)
KW - asparaginyl carboksypeptidase (ACP)
KW - cysteine protease
KW - legumain
KW - peptide asparaginyl ligase (PAL)
KW - prolegumain
KW - δ-secretase
U2 - 10.3390/ijms232415983
DO - 10.3390/ijms232415983
M3 - Review
C2 - 36555634
AN - SCOPUS:85144730556
VL - 23
JO - International Journal of Molecular Sciences (Online)
JF - International Journal of Molecular Sciences (Online)
SN - 1661-6596
IS - 24
M1 - 15983
ER -
ID: 330894501