The interface between transcription and mechanisms maintaining genome integrity
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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The interface between transcription and mechanisms maintaining genome integrity. / Svejstrup, Jesper Q.
I: Trends in Biochemical Sciences, Bind 35, Nr. 6, 2010, s. 333-338.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - The interface between transcription and mechanisms maintaining genome integrity
AU - Svejstrup, Jesper Q.
N1 - Funding Information: I apologize to the many researchers whose excellent papers were not referenced in this review owing to space restraints. Research in the Svejstrup laboratory is supported by a generous in-house grant from Cancer Research UK, and by funding provided by Association for International Cancer Research (AICR). A. Barbara Dirac-Svejstrup is thanked for helpful comments on the manuscript.
PY - 2010
Y1 - 2010
N2 - Maintaining genome integrity is crucial for correctly regulated gene expression. Conversely, the process of transcription fundamentally impinges on genome stability, necessitating cellular mechanisms that lessen the genome destabilizing effect of reading genes. This review provides an overview of our present knowledge of how eukaryotic RNA polymerase II transcription affects, and is affected by, other DNA-related processes such as chromatin remodeling, DNA repair, recombination and replication.
AB - Maintaining genome integrity is crucial for correctly regulated gene expression. Conversely, the process of transcription fundamentally impinges on genome stability, necessitating cellular mechanisms that lessen the genome destabilizing effect of reading genes. This review provides an overview of our present knowledge of how eukaryotic RNA polymerase II transcription affects, and is affected by, other DNA-related processes such as chromatin remodeling, DNA repair, recombination and replication.
U2 - 10.1016/j.tibs.2010.02.001
DO - 10.1016/j.tibs.2010.02.001
M3 - Review
C2 - 20194025
AN - SCOPUS:77954759085
VL - 35
SP - 333
EP - 338
JO - Trends in Biochemical Sciences
JF - Trends in Biochemical Sciences
SN - 0968-0004
IS - 6
ER -
ID: 330899375