The impact of comorbidities on survival in oral cancer patients: a population-based, case-control study
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The impact of comorbidities on survival in oral cancer patients : a population-based, case-control study. / Ghanizada, Mustafa; Jakobsen, Kathrine Kronberg; Jensen, Jakob Schmidt; Wessel, Irene; Filtenborg Tvedskov, Jesper; Grønhøj, Christian; von Buchwald, Christian.
I: Acta Oncologica, Bind 60, Nr. 2, 2021, s. 173-179.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - The impact of comorbidities on survival in oral cancer patients
T2 - a population-based, case-control study
AU - Ghanizada, Mustafa
AU - Jakobsen, Kathrine Kronberg
AU - Jensen, Jakob Schmidt
AU - Wessel, Irene
AU - Filtenborg Tvedskov, Jesper
AU - Grønhøj, Christian
AU - von Buchwald, Christian
N1 - Publisher Copyright: © 2020 Acta Oncologica Foundation.
PY - 2021
Y1 - 2021
N2 - Background: Comorbidities have shown to highly influence the outcome and risk of death of head and neck cancer patients. The purpose of this study was to examine the comorbidities among oral cavity squamous cell carcinoma (OSCC) patients, and to investigate the impact of comorbidities on overall survival (OS) and recurrence free survival (RFS). Methods: Patients diagnosed with OSCC in Eastern Denmark in the period 2000–2014 and treated with curative intend were included. Patients data were linked to the Danish National Patients Register to identify comorbidities based on the Charlson Comorbidity Index (CCI) at the time of diagnosis and five years after diagnosis. Each patient was age-and sex-matched in a 1:10 ratio with an age and sex matched reference group. Results: A total of 1,183 patients and 11,830 controls were included. Overall this study found comorbidities to be more common among OSCC compared to the reference group both at the time of diagnosis and five years after. The 5-year OS among patients with a CCI score of zero, one, two, and three or above was 60%, 44%, 41%, and 40%, respectively. Similarly, the multivariate cox-regression analysis showed that patients with increasing CCI score also had an increasing risk of death compared to patients with no comorbidities. Conclusion: OSCC patients had significantly higher comorbidity burden at diagnosis and risk of developing additional comorbidities after diagnosis compared to the reference population. Survival outcomes decreased significantly with higher CCI.
AB - Background: Comorbidities have shown to highly influence the outcome and risk of death of head and neck cancer patients. The purpose of this study was to examine the comorbidities among oral cavity squamous cell carcinoma (OSCC) patients, and to investigate the impact of comorbidities on overall survival (OS) and recurrence free survival (RFS). Methods: Patients diagnosed with OSCC in Eastern Denmark in the period 2000–2014 and treated with curative intend were included. Patients data were linked to the Danish National Patients Register to identify comorbidities based on the Charlson Comorbidity Index (CCI) at the time of diagnosis and five years after diagnosis. Each patient was age-and sex-matched in a 1:10 ratio with an age and sex matched reference group. Results: A total of 1,183 patients and 11,830 controls were included. Overall this study found comorbidities to be more common among OSCC compared to the reference group both at the time of diagnosis and five years after. The 5-year OS among patients with a CCI score of zero, one, two, and three or above was 60%, 44%, 41%, and 40%, respectively. Similarly, the multivariate cox-regression analysis showed that patients with increasing CCI score also had an increasing risk of death compared to patients with no comorbidities. Conclusion: OSCC patients had significantly higher comorbidity burden at diagnosis and risk of developing additional comorbidities after diagnosis compared to the reference population. Survival outcomes decreased significantly with higher CCI.
KW - Charlson Comorbidity Index (CCI)
KW - comorbidity
KW - Oral cavity cancer
KW - overall survival
KW - recurrence free survival
U2 - 10.1080/0284186X.2020.1836393
DO - 10.1080/0284186X.2020.1836393
M3 - Journal article
C2 - 33103528
AN - SCOPUS:85094868891
VL - 60
SP - 173
EP - 179
JO - Acta Oncologica
JF - Acta Oncologica
SN - 1100-1704
IS - 2
ER -
ID: 269600738