The effects of sodium nitroprusside on cerebral blood flow and cerebral venous blood gases. II. Observations in awake man during successive blood pressure reduction
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The effects of sodium nitroprusside on cerebral blood flow and cerebral venous blood gases. II. Observations in awake man during successive blood pressure reduction. / Henriksen, L; Paulson, O B.
I: European Journal of Clinical Investigation, Bind 12, Nr. 5, 10.1982, s. 389-93.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - The effects of sodium nitroprusside on cerebral blood flow and cerebral venous blood gases. II. Observations in awake man during successive blood pressure reduction
AU - Henriksen, L
AU - Paulson, O B
PY - 1982/10
Y1 - 1982/10
N2 - Cerebral blood flow (CBF) and cerebral venous blood gases were investigated in seven awake patients during hypotension induced with sodium nitroprusside. Infusion of the drug into the internal carotid artery produced no changes in cerebral haemodynamics. Intravenous nitroprusside infusion resulted in a decrease in both CBF and jugular venous PO2 (P less than 0.01, respectively). Reducing mean arterial blood pressure by 18% and 43% produced a mean CBF fall of 6% and 27% respectively. Arteriovenous oxygen difference increased in consonance with the CBF decrease (P less than 0.01). Arterial PCO2 fell during the infusion (P less than 0.01). At 18% blood pressure reduction, the observed PCO2 decrease of 0.25 kPa could account for the 6% CBF decrease. At 43% blood pressure reduction, PCO2 fell by 0.53 kPa, a decrease which could not explain the observed CBF fall of 27%. Dizziness and incipient fainting occurred in the patients at this point. It is concluded that sodium nitroprusside has a minor but significant effect on cerebral haemodynamics in normal awake man.
AB - Cerebral blood flow (CBF) and cerebral venous blood gases were investigated in seven awake patients during hypotension induced with sodium nitroprusside. Infusion of the drug into the internal carotid artery produced no changes in cerebral haemodynamics. Intravenous nitroprusside infusion resulted in a decrease in both CBF and jugular venous PO2 (P less than 0.01, respectively). Reducing mean arterial blood pressure by 18% and 43% produced a mean CBF fall of 6% and 27% respectively. Arteriovenous oxygen difference increased in consonance with the CBF decrease (P less than 0.01). Arterial PCO2 fell during the infusion (P less than 0.01). At 18% blood pressure reduction, the observed PCO2 decrease of 0.25 kPa could account for the 6% CBF decrease. At 43% blood pressure reduction, PCO2 fell by 0.53 kPa, a decrease which could not explain the observed CBF fall of 27%. Dizziness and incipient fainting occurred in the patients at this point. It is concluded that sodium nitroprusside has a minor but significant effect on cerebral haemodynamics in normal awake man.
KW - Adult
KW - Blood Gas Analysis
KW - Blood Pressure/drug effects
KW - Carbon Dioxide/blood
KW - Cerebrovascular Circulation/drug effects
KW - Female
KW - Ferricyanides/pharmacology
KW - Homeostasis/drug effects
KW - Humans
KW - Hypotension/chemically induced
KW - Infusions, Intra-Arterial
KW - Infusions, Parenteral
KW - Male
KW - Middle Aged
KW - Nitroprusside/administration & dosage
KW - Oxygen/blood
U2 - 10.1111/j.1365-2362.1982.tb00685.x
DO - 10.1111/j.1365-2362.1982.tb00685.x
M3 - Journal article
C2 - 6816609
VL - 12
SP - 389
EP - 393
JO - European Journal of Clinical Investigation, Supplement
JF - European Journal of Clinical Investigation, Supplement
SN - 0960-135X
IS - 5
ER -
ID: 279595711