The effects of sodium nitroprusside on cerebral blood flow and cerebral venous blood gases: I. Observations in awake man during and following moderate blood pressure reduction

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Standard

The effects of sodium nitroprusside on cerebral blood flow and cerebral venous blood gases : I. Observations in awake man during and following moderate blood pressure reduction. / HENRIKSEN, LEIF; PAULSON, OLAF B.; LAURITZEN, MARTIN.

I: European Journal of Clinical Investigation, Bind 12, Nr. 5, 01.01.1982, s. 383-387.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

HENRIKSEN, LEIF, PAULSON, OLAFB & LAURITZEN, MARTIN 1982, 'The effects of sodium nitroprusside on cerebral blood flow and cerebral venous blood gases: I. Observations in awake man during and following moderate blood pressure reduction', European Journal of Clinical Investigation, bind 12, nr. 5, s. 383-387. https://doi.org/10.1111/j.1365-2362.1982.tb00684.x

APA

HENRIKSEN, LEIF., PAULSON, OLAF. B., & LAURITZEN, MARTIN. (1982). The effects of sodium nitroprusside on cerebral blood flow and cerebral venous blood gases: I. Observations in awake man during and following moderate blood pressure reduction. European Journal of Clinical Investigation, 12(5), 383-387. https://doi.org/10.1111/j.1365-2362.1982.tb00684.x

Vancouver

HENRIKSEN LEIF, PAULSON OLAFB, LAURITZEN MARTIN. The effects of sodium nitroprusside on cerebral blood flow and cerebral venous blood gases: I. Observations in awake man during and following moderate blood pressure reduction. European Journal of Clinical Investigation. 1982 jan. 1;12(5):383-387. https://doi.org/10.1111/j.1365-2362.1982.tb00684.x

Author

HENRIKSEN, LEIF ; PAULSON, OLAF B. ; LAURITZEN, MARTIN. / The effects of sodium nitroprusside on cerebral blood flow and cerebral venous blood gases : I. Observations in awake man during and following moderate blood pressure reduction. I: European Journal of Clinical Investigation. 1982 ; Bind 12, Nr. 5. s. 383-387.

Bibtex

@article{a9b07be941b446ecb5e7fccce42403b2,
title = "The effects of sodium nitroprusside on cerebral blood flow and cerebral venous blood gases: I. Observations in awake man during and following moderate blood pressure reduction",
abstract = "Abstract. Cerebral blood flow (CBF) and cerebral venous blood gases were studied in seven patients before, during and after intravenous sodium nitroprusside infusion. The 133Xe intra‐arterial injection method was used for the CBF measurements. A dose of sodium nitroprusside (mean 1·0 mg, mean infusion time 20 min), which reduced mean arterial blood pressure by a mean of 17%, resulted in a 13% decrease in CBF (P<0·05). Measurements obtained 5 and 20 min after termination of the sodium nitroprusside infusion showed no signs of a hyperaemic rebound effect. Arterial PCO2, metabolic rate of oxygen, arterio‐venous oxygen difference and venous PO2 remained unchanged during and after infusion. It is concluded that sodium nitroprusside has a minor effect on cerebral haemodynamics, an effect that might be mediated by the sympathetic nervous system.",
keywords = "autoregulation, cerebral blood flow, hypotension, rebound hyperaemic, Sodium nitroprusside",
author = "LEIF HENRIKSEN and PAULSON, {OLAF B.} and MARTIN LAURITZEN",
year = "1982",
month = jan,
day = "1",
doi = "10.1111/j.1365-2362.1982.tb00684.x",
language = "English",
volume = "12",
pages = "383--387",
journal = "European Journal of Clinical Investigation, Supplement",
issn = "0960-135X",
publisher = "Wiley-Blackwell",
number = "5",

}

RIS

TY - JOUR

T1 - The effects of sodium nitroprusside on cerebral blood flow and cerebral venous blood gases

T2 - I. Observations in awake man during and following moderate blood pressure reduction

AU - HENRIKSEN, LEIF

AU - PAULSON, OLAF B.

AU - LAURITZEN, MARTIN

PY - 1982/1/1

Y1 - 1982/1/1

N2 - Abstract. Cerebral blood flow (CBF) and cerebral venous blood gases were studied in seven patients before, during and after intravenous sodium nitroprusside infusion. The 133Xe intra‐arterial injection method was used for the CBF measurements. A dose of sodium nitroprusside (mean 1·0 mg, mean infusion time 20 min), which reduced mean arterial blood pressure by a mean of 17%, resulted in a 13% decrease in CBF (P<0·05). Measurements obtained 5 and 20 min after termination of the sodium nitroprusside infusion showed no signs of a hyperaemic rebound effect. Arterial PCO2, metabolic rate of oxygen, arterio‐venous oxygen difference and venous PO2 remained unchanged during and after infusion. It is concluded that sodium nitroprusside has a minor effect on cerebral haemodynamics, an effect that might be mediated by the sympathetic nervous system.

AB - Abstract. Cerebral blood flow (CBF) and cerebral venous blood gases were studied in seven patients before, during and after intravenous sodium nitroprusside infusion. The 133Xe intra‐arterial injection method was used for the CBF measurements. A dose of sodium nitroprusside (mean 1·0 mg, mean infusion time 20 min), which reduced mean arterial blood pressure by a mean of 17%, resulted in a 13% decrease in CBF (P<0·05). Measurements obtained 5 and 20 min after termination of the sodium nitroprusside infusion showed no signs of a hyperaemic rebound effect. Arterial PCO2, metabolic rate of oxygen, arterio‐venous oxygen difference and venous PO2 remained unchanged during and after infusion. It is concluded that sodium nitroprusside has a minor effect on cerebral haemodynamics, an effect that might be mediated by the sympathetic nervous system.

KW - autoregulation

KW - cerebral blood flow

KW - hypotension

KW - rebound hyperaemic

KW - Sodium nitroprusside

UR - http://www.scopus.com/inward/record.url?scp=0019901847&partnerID=8YFLogxK

U2 - 10.1111/j.1365-2362.1982.tb00684.x

DO - 10.1111/j.1365-2362.1982.tb00684.x

M3 - Journal article

C2 - 6816608

AN - SCOPUS:0019901847

VL - 12

SP - 383

EP - 387

JO - European Journal of Clinical Investigation, Supplement

JF - European Journal of Clinical Investigation, Supplement

SN - 0960-135X

IS - 5

ER -

ID: 201459713