The effect of MTHFR(C677T) genotype on plasma homocysteine concentrations in healthy children is influenced by gender
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The effect of MTHFR(C677T) genotype on plasma homocysteine concentrations in healthy children is influenced by gender. / Papoutsakis, Constantina; Yiannakouris, N; Manios, Yannis; Papaconstantinou, Evaggelos; Magkos, Faidon; Schulpis, K H; Zampelas, Antonis; Matalas, Antonia L.
I: European Journal of Clinical Nutrition, Bind 60, Nr. 2, 2006, s. 155-162.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - The effect of MTHFR(C677T) genotype on plasma homocysteine concentrations in healthy children is influenced by gender
AU - Papoutsakis, Constantina
AU - Yiannakouris, N
AU - Manios, Yannis
AU - Papaconstantinou, Evaggelos
AU - Magkos, Faidon
AU - Schulpis, K H
AU - Zampelas, Antonis
AU - Matalas, Antonia L
N1 - (Ekstern)
PY - 2006
Y1 - 2006
N2 - Objective: To explore the influence of gender, together with folate status, on the relation between the common methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and plasma total homocysteine (tHcy) concentrations in healthy children.Design: Cross-sectional study by face-to-face interview.Setting and subjects: A total of 186 sixth-grade students participated from twelve randomly selected primary schools in Volos, Greece.Methods: Fasting tHcy, folate, and vitamin B12 were measured in plasma. The MTHFR genotypes were determined. Anthropometric and dietary intake data by 24-h recall were collected.Results: Geometric means for plasma tHcy, plasma folate and energy-adjusted dietary folate did not differ between females and males. The homozygous mutant TT genotype was associated with higher tHcy only in children with lower plasma folate concentrations (<19.9 nmol/l, P = 0.012). As a significant gender interaction was observed (P = 0.050), we stratified the lower plasma folate group by gender and found that the association between the genotype and tHcy was restricted to males (P = 0.026). Similar results were obtained when folate status was based on estimated dietary folate. Specifically, only TT males that reported lower dietary folate consumption (<37 microg/MJ/day) had tHcy that was significantly higher than tHcy levels of C-allele carriers (P = 0.001).Conclusions: Under conditions of lower folate status (as estimated by either plasma concentration or reported dietary consumption), gender modifies the association of the MTHFR(C677T) polymorphism with tHcy concentrations in healthy children.Sponsorship: Kellog Europe.
AB - Objective: To explore the influence of gender, together with folate status, on the relation between the common methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and plasma total homocysteine (tHcy) concentrations in healthy children.Design: Cross-sectional study by face-to-face interview.Setting and subjects: A total of 186 sixth-grade students participated from twelve randomly selected primary schools in Volos, Greece.Methods: Fasting tHcy, folate, and vitamin B12 were measured in plasma. The MTHFR genotypes were determined. Anthropometric and dietary intake data by 24-h recall were collected.Results: Geometric means for plasma tHcy, plasma folate and energy-adjusted dietary folate did not differ between females and males. The homozygous mutant TT genotype was associated with higher tHcy only in children with lower plasma folate concentrations (<19.9 nmol/l, P = 0.012). As a significant gender interaction was observed (P = 0.050), we stratified the lower plasma folate group by gender and found that the association between the genotype and tHcy was restricted to males (P = 0.026). Similar results were obtained when folate status was based on estimated dietary folate. Specifically, only TT males that reported lower dietary folate consumption (<37 microg/MJ/day) had tHcy that was significantly higher than tHcy levels of C-allele carriers (P = 0.001).Conclusions: Under conditions of lower folate status (as estimated by either plasma concentration or reported dietary consumption), gender modifies the association of the MTHFR(C677T) polymorphism with tHcy concentrations in healthy children.Sponsorship: Kellog Europe.
KW - Analysis of Variance
KW - Child
KW - Cross-Sectional Studies
KW - Diet
KW - Female
KW - Folic Acid/blood
KW - Genotype
KW - Greece
KW - Homocysteine/blood
KW - Humans
KW - Male
KW - Mental Recall
KW - Methylenetetrahydrofolate Reductase (NADPH2)/genetics
KW - Polymorphism, Single Nucleotide
KW - Sex Factors
KW - Vitamin B 12/blood
U2 - 10.1038/sj.ejcn.1602280
DO - 10.1038/sj.ejcn.1602280
M3 - Journal article
C2 - 16234842
VL - 60
SP - 155
EP - 162
JO - European Journal of Clinical Nutrition
JF - European Journal of Clinical Nutrition
SN - 0954-3007
IS - 2
ER -
ID: 297205856