The Duffy-null genotype and risk of infection

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

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The Duffy-null genotype and risk of infection. / Legge, Sophie E.; Christensen, Rune H.; Petersen, Liselotte; Pardiñas, Antonio F.; Bracher-Smith, Matthew; Knapper, Steven; Bybjerg-Grauholm, Jonas; Baekvad-Hansen, Marie; Hougaard, David M.; Werge, Thomas; Nordentoft, Merete; Mortensen, Preben Bo; Owen, Michael J.; O'Donovan, Michael C.; Benros, Michael E.; Walters, James T.R.

I: Human Molecular Genetics, Bind 29, Nr. 20, 2020, s. 3341-3349.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Legge, SE, Christensen, RH, Petersen, L, Pardiñas, AF, Bracher-Smith, M, Knapper, S, Bybjerg-Grauholm, J, Baekvad-Hansen, M, Hougaard, DM, Werge, T, Nordentoft, M, Mortensen, PB, Owen, MJ, O'Donovan, MC, Benros, ME & Walters, JTR 2020, 'The Duffy-null genotype and risk of infection', Human Molecular Genetics, bind 29, nr. 20, s. 3341-3349. https://doi.org/10.1093/hmg/ddaa208

APA

Legge, S. E., Christensen, R. H., Petersen, L., Pardiñas, A. F., Bracher-Smith, M., Knapper, S., Bybjerg-Grauholm, J., Baekvad-Hansen, M., Hougaard, D. M., Werge, T., Nordentoft, M., Mortensen, P. B., Owen, M. J., O'Donovan, M. C., Benros, M. E., & Walters, J. T. R. (2020). The Duffy-null genotype and risk of infection. Human Molecular Genetics, 29(20), 3341-3349. https://doi.org/10.1093/hmg/ddaa208

Vancouver

Legge SE, Christensen RH, Petersen L, Pardiñas AF, Bracher-Smith M, Knapper S o.a. The Duffy-null genotype and risk of infection. Human Molecular Genetics. 2020;29(20):3341-3349. https://doi.org/10.1093/hmg/ddaa208

Author

Legge, Sophie E. ; Christensen, Rune H. ; Petersen, Liselotte ; Pardiñas, Antonio F. ; Bracher-Smith, Matthew ; Knapper, Steven ; Bybjerg-Grauholm, Jonas ; Baekvad-Hansen, Marie ; Hougaard, David M. ; Werge, Thomas ; Nordentoft, Merete ; Mortensen, Preben Bo ; Owen, Michael J. ; O'Donovan, Michael C. ; Benros, Michael E. ; Walters, James T.R. / The Duffy-null genotype and risk of infection. I: Human Molecular Genetics. 2020 ; Bind 29, Nr. 20. s. 3341-3349.

Bibtex

@article{dd2fe0e5b74f43cebfab8c95d0cf5c92,
title = "The Duffy-null genotype and risk of infection",
abstract = "Many medical treatments, from oncology to psychiatry, can lower white blood cell counts and thus access to these treatments can be restricted to individuals with normal levels of white blood cells, principally in order to minimize risk of serious infection. This adversely affects individuals of African or Middle Eastern ancestries who have on average a reduced number of circulating white blood cells, because of the Duffy-null (CC) genotype at rs2814778 in the ACKR1 gene. Here, we investigate whether the Duffy-null genotype is associated with the risk of infection using the UK Biobank sample and the iPSYCH Danish case-cohort study, two population-based samples from different countries and age ranges. We found that a high proportion of those with the Duffy-null genotype (21%) had a neutrophil count below the threshold often used as a cut-off for access to relevant treatments, compared with 1% of those with the TC/TT genotype. In addition we found that despite its strong association with lower average neutrophil counts, the Duffy-null genotype was not associated with an increased risk of infection, viral or bacterial. These results have widespread implications for the clinical treatment of individuals of African ancestry and indicate that neutrophil thresholds to access treatments could be lowered in individuals with the Duffy-null genotype without an increased risk of infection.",
author = "Legge, {Sophie E.} and Christensen, {Rune H.} and Liselotte Petersen and Pardi{\~n}as, {Antonio F.} and Matthew Bracher-Smith and Steven Knapper and Jonas Bybjerg-Grauholm and Marie Baekvad-Hansen and Hougaard, {David M.} and Thomas Werge and Merete Nordentoft and Mortensen, {Preben Bo} and Owen, {Michael J.} and O'Donovan, {Michael C.} and Benros, {Michael E.} and Walters, {James T.R.}",
year = "2020",
doi = "10.1093/hmg/ddaa208",
language = "English",
volume = "29",
pages = "3341--3349",
journal = "Human Molecular Genetics",
issn = "0964-6906",
publisher = "Oxford University Press",
number = "20",

}

RIS

TY - JOUR

T1 - The Duffy-null genotype and risk of infection

AU - Legge, Sophie E.

AU - Christensen, Rune H.

AU - Petersen, Liselotte

AU - Pardiñas, Antonio F.

AU - Bracher-Smith, Matthew

AU - Knapper, Steven

AU - Bybjerg-Grauholm, Jonas

AU - Baekvad-Hansen, Marie

AU - Hougaard, David M.

AU - Werge, Thomas

AU - Nordentoft, Merete

AU - Mortensen, Preben Bo

AU - Owen, Michael J.

AU - O'Donovan, Michael C.

AU - Benros, Michael E.

AU - Walters, James T.R.

PY - 2020

Y1 - 2020

N2 - Many medical treatments, from oncology to psychiatry, can lower white blood cell counts and thus access to these treatments can be restricted to individuals with normal levels of white blood cells, principally in order to minimize risk of serious infection. This adversely affects individuals of African or Middle Eastern ancestries who have on average a reduced number of circulating white blood cells, because of the Duffy-null (CC) genotype at rs2814778 in the ACKR1 gene. Here, we investigate whether the Duffy-null genotype is associated with the risk of infection using the UK Biobank sample and the iPSYCH Danish case-cohort study, two population-based samples from different countries and age ranges. We found that a high proportion of those with the Duffy-null genotype (21%) had a neutrophil count below the threshold often used as a cut-off for access to relevant treatments, compared with 1% of those with the TC/TT genotype. In addition we found that despite its strong association with lower average neutrophil counts, the Duffy-null genotype was not associated with an increased risk of infection, viral or bacterial. These results have widespread implications for the clinical treatment of individuals of African ancestry and indicate that neutrophil thresholds to access treatments could be lowered in individuals with the Duffy-null genotype without an increased risk of infection.

AB - Many medical treatments, from oncology to psychiatry, can lower white blood cell counts and thus access to these treatments can be restricted to individuals with normal levels of white blood cells, principally in order to minimize risk of serious infection. This adversely affects individuals of African or Middle Eastern ancestries who have on average a reduced number of circulating white blood cells, because of the Duffy-null (CC) genotype at rs2814778 in the ACKR1 gene. Here, we investigate whether the Duffy-null genotype is associated with the risk of infection using the UK Biobank sample and the iPSYCH Danish case-cohort study, two population-based samples from different countries and age ranges. We found that a high proportion of those with the Duffy-null genotype (21%) had a neutrophil count below the threshold often used as a cut-off for access to relevant treatments, compared with 1% of those with the TC/TT genotype. In addition we found that despite its strong association with lower average neutrophil counts, the Duffy-null genotype was not associated with an increased risk of infection, viral or bacterial. These results have widespread implications for the clinical treatment of individuals of African ancestry and indicate that neutrophil thresholds to access treatments could be lowered in individuals with the Duffy-null genotype without an increased risk of infection.

U2 - 10.1093/hmg/ddaa208

DO - 10.1093/hmg/ddaa208

M3 - Journal article

C2 - 32959868

AN - SCOPUS:85098839366

VL - 29

SP - 3341

EP - 3349

JO - Human Molecular Genetics

JF - Human Molecular Genetics

SN - 0964-6906

IS - 20

ER -

ID: 254990687