The Danish PET/depression project: cognitive function and regional cerebral blood flow.
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The Danish PET/depression project: cognitive function and regional cerebral blood flow. / Ravnkilde, B; Videbech, P; Clemmensen, K; Egander, A; Rasmussen, N A; Gjedde, A; Rosenberg, R; Gade, A.
I: Acta Psychiatrica Scandinavica, Bind 108, Nr. 1, 2003, s. 32-40.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - The Danish PET/depression project: cognitive function and regional cerebral blood flow.
AU - Ravnkilde, B
AU - Videbech, P
AU - Clemmensen, K
AU - Egander, A
AU - Rasmussen, N A
AU - Gjedde, A
AU - Rosenberg, R
AU - Gade, A
PY - 2003
Y1 - 2003
N2 - OBJECTIVE: To clarify the relationship between cognitive functions and regional cerebral blood flow (rCBF) in a large group of depressed patients compared with healthy controls. METHOD: A set of principal components was extracted from scores of a battery of neuropsychological tests of 40 patients suffering from major depression and 49 healthy controls. The components were correlated by multiple linear regression analyses to selected regions of interest in the brain obtained from positron emission tomography images. RESULTS: In contrast to findings in the healthy controls, cognitive functions in the depressed patients correlated significantly with rCBF in specified regions of interest in only a few instances. CONCLUSION: Our study indicates that disturbed cognitive functions in depression do not relate to specific areas of the brain in the same way as normal cognitive functioning, suggesting that the abnormalities of brain function in major depression may be qualitative, rather than quantitative, in nature.
AB - OBJECTIVE: To clarify the relationship between cognitive functions and regional cerebral blood flow (rCBF) in a large group of depressed patients compared with healthy controls. METHOD: A set of principal components was extracted from scores of a battery of neuropsychological tests of 40 patients suffering from major depression and 49 healthy controls. The components were correlated by multiple linear regression analyses to selected regions of interest in the brain obtained from positron emission tomography images. RESULTS: In contrast to findings in the healthy controls, cognitive functions in the depressed patients correlated significantly with rCBF in specified regions of interest in only a few instances. CONCLUSION: Our study indicates that disturbed cognitive functions in depression do not relate to specific areas of the brain in the same way as normal cognitive functioning, suggesting that the abnormalities of brain function in major depression may be qualitative, rather than quantitative, in nature.
M3 - Journal article
C2 - 12807375
VL - 108
SP - 32
EP - 40
JO - Acta Psychiatrica Scandinavica
JF - Acta Psychiatrica Scandinavica
SN - 0001-690X
IS - 1
ER -
ID: 14946371