The correlates of neonatal complement component 3 and 4 protein concentrations with a focus on psychiatric and autoimmune disorders

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Standard

The correlates of neonatal complement component 3 and 4 protein concentrations with a focus on psychiatric and autoimmune disorders. / Borbye-Lorenzen, Nis; Zhu, Zhihong; Agerbo, Esben; Albiñana, Clara; Benros, Michael E.; Bian, Beilei; Børglum, Anders D.; Bulik, Cynthia M.; Debost, Jean-Christophe Philippe Goldtsche; Grove, Jakob; Hougaard, David M.; McRae, Allan F.; Mors, Ole; Mortensen, Preben Bo; Musliner, Katherine L.; Nordentoft, Merete; Petersen, Liselotte V.; Privé, Florian; Sidorenko, Julia; Skogstrand, Kristin; Werge, Thomas; Wray, Naomi R.; Vilhjálmsson, Bjarni J.; McGrath, John J.

I: Cell Genomics, Bind 3, Nr. 12, 100457, 2023.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Borbye-Lorenzen, N, Zhu, Z, Agerbo, E, Albiñana, C, Benros, ME, Bian, B, Børglum, AD, Bulik, CM, Debost, J-CPG, Grove, J, Hougaard, DM, McRae, AF, Mors, O, Mortensen, PB, Musliner, KL, Nordentoft, M, Petersen, LV, Privé, F, Sidorenko, J, Skogstrand, K, Werge, T, Wray, NR, Vilhjálmsson, BJ & McGrath, JJ 2023, 'The correlates of neonatal complement component 3 and 4 protein concentrations with a focus on psychiatric and autoimmune disorders', Cell Genomics, bind 3, nr. 12, 100457. https://doi.org/10.1016/j.xgen.2023.100457

APA

Borbye-Lorenzen, N., Zhu, Z., Agerbo, E., Albiñana, C., Benros, M. E., Bian, B., Børglum, A. D., Bulik, C. M., Debost, J-C. P. G., Grove, J., Hougaard, D. M., McRae, A. F., Mors, O., Mortensen, P. B., Musliner, K. L., Nordentoft, M., Petersen, L. V., Privé, F., Sidorenko, J., ... McGrath, J. J. (2023). The correlates of neonatal complement component 3 and 4 protein concentrations with a focus on psychiatric and autoimmune disorders. Cell Genomics, 3(12), [100457]. https://doi.org/10.1016/j.xgen.2023.100457

Vancouver

Borbye-Lorenzen N, Zhu Z, Agerbo E, Albiñana C, Benros ME, Bian B o.a. The correlates of neonatal complement component 3 and 4 protein concentrations with a focus on psychiatric and autoimmune disorders. Cell Genomics. 2023;3(12). 100457. https://doi.org/10.1016/j.xgen.2023.100457

Author

Borbye-Lorenzen, Nis ; Zhu, Zhihong ; Agerbo, Esben ; Albiñana, Clara ; Benros, Michael E. ; Bian, Beilei ; Børglum, Anders D. ; Bulik, Cynthia M. ; Debost, Jean-Christophe Philippe Goldtsche ; Grove, Jakob ; Hougaard, David M. ; McRae, Allan F. ; Mors, Ole ; Mortensen, Preben Bo ; Musliner, Katherine L. ; Nordentoft, Merete ; Petersen, Liselotte V. ; Privé, Florian ; Sidorenko, Julia ; Skogstrand, Kristin ; Werge, Thomas ; Wray, Naomi R. ; Vilhjálmsson, Bjarni J. ; McGrath, John J. / The correlates of neonatal complement component 3 and 4 protein concentrations with a focus on psychiatric and autoimmune disorders. I: Cell Genomics. 2023 ; Bind 3, Nr. 12.

Bibtex

@article{461b035de3fa4c7b98e3e718bf5a57d4,
title = "The correlates of neonatal complement component 3 and 4 protein concentrations with a focus on psychiatric and autoimmune disorders",
abstract = "Complement components have been linked to schizophrenia and autoimmune disorders. We examined the association between neonatal circulating C3 and C4 protein concentrations in 68,768 neonates and the risk of six mental disorders. We completed genome-wide association studies (GWASs) for C3 and C4 and applied the summary statistics in Mendelian randomization and phenome-wide association studies related to mental and autoimmune disorders. The GWASs for C3 and C4 protein concentrations identified 15 and 36 independent loci, respectively. We found no associations between neonatal C3 and C4 concentrations and mental disorders in the total sample (both sexes combined); however, post-hoc analyses found that a higher C3 concentration was associated with a reduced risk of schizophrenia in females. Mendelian randomization based on C4 summary statistics found an altered risk of five types of autoimmune disorders. Our study adds to our understanding of the associations between C3 and C4 concentrations and subsequent mental and autoimmune disorders.",
author = "Nis Borbye-Lorenzen and Zhihong Zhu and Esben Agerbo and Clara Albi{\~n}ana and Benros, {Michael E.} and Beilei Bian and B{\o}rglum, {Anders D.} and Bulik, {Cynthia M.} and Debost, {Jean-Christophe Philippe Goldtsche} and Jakob Grove and Hougaard, {David M.} and McRae, {Allan F.} and Ole Mors and Mortensen, {Preben Bo} and Musliner, {Katherine L.} and Merete Nordentoft and Petersen, {Liselotte V.} and Florian Priv{\'e} and Julia Sidorenko and Kristin Skogstrand and Thomas Werge and Wray, {Naomi R.} and Vilhj{\'a}lmsson, {Bjarni J.} and McGrath, {John J.}",
note = "{\textcopyright} 2023 The Author(s).",
year = "2023",
doi = "10.1016/j.xgen.2023.100457",
language = "English",
volume = "3",
journal = "Cell Genomics",
issn = "2666-979x",
publisher = "Elsevier",
number = "12",

}

RIS

TY - JOUR

T1 - The correlates of neonatal complement component 3 and 4 protein concentrations with a focus on psychiatric and autoimmune disorders

AU - Borbye-Lorenzen, Nis

AU - Zhu, Zhihong

AU - Agerbo, Esben

AU - Albiñana, Clara

AU - Benros, Michael E.

AU - Bian, Beilei

AU - Børglum, Anders D.

AU - Bulik, Cynthia M.

AU - Debost, Jean-Christophe Philippe Goldtsche

AU - Grove, Jakob

AU - Hougaard, David M.

AU - McRae, Allan F.

AU - Mors, Ole

AU - Mortensen, Preben Bo

AU - Musliner, Katherine L.

AU - Nordentoft, Merete

AU - Petersen, Liselotte V.

AU - Privé, Florian

AU - Sidorenko, Julia

AU - Skogstrand, Kristin

AU - Werge, Thomas

AU - Wray, Naomi R.

AU - Vilhjálmsson, Bjarni J.

AU - McGrath, John J.

N1 - © 2023 The Author(s).

PY - 2023

Y1 - 2023

N2 - Complement components have been linked to schizophrenia and autoimmune disorders. We examined the association between neonatal circulating C3 and C4 protein concentrations in 68,768 neonates and the risk of six mental disorders. We completed genome-wide association studies (GWASs) for C3 and C4 and applied the summary statistics in Mendelian randomization and phenome-wide association studies related to mental and autoimmune disorders. The GWASs for C3 and C4 protein concentrations identified 15 and 36 independent loci, respectively. We found no associations between neonatal C3 and C4 concentrations and mental disorders in the total sample (both sexes combined); however, post-hoc analyses found that a higher C3 concentration was associated with a reduced risk of schizophrenia in females. Mendelian randomization based on C4 summary statistics found an altered risk of five types of autoimmune disorders. Our study adds to our understanding of the associations between C3 and C4 concentrations and subsequent mental and autoimmune disorders.

AB - Complement components have been linked to schizophrenia and autoimmune disorders. We examined the association between neonatal circulating C3 and C4 protein concentrations in 68,768 neonates and the risk of six mental disorders. We completed genome-wide association studies (GWASs) for C3 and C4 and applied the summary statistics in Mendelian randomization and phenome-wide association studies related to mental and autoimmune disorders. The GWASs for C3 and C4 protein concentrations identified 15 and 36 independent loci, respectively. We found no associations between neonatal C3 and C4 concentrations and mental disorders in the total sample (both sexes combined); however, post-hoc analyses found that a higher C3 concentration was associated with a reduced risk of schizophrenia in females. Mendelian randomization based on C4 summary statistics found an altered risk of five types of autoimmune disorders. Our study adds to our understanding of the associations between C3 and C4 concentrations and subsequent mental and autoimmune disorders.

U2 - 10.1016/j.xgen.2023.100457

DO - 10.1016/j.xgen.2023.100457

M3 - Journal article

C2 - 38116117

VL - 3

JO - Cell Genomics

JF - Cell Genomics

SN - 2666-979x

IS - 12

M1 - 100457

ER -

ID: 377636476