The Brain's Glymphatic System: Current Controversies
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- The Brain’s Glymphatic System. Current Controversies
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The glymphatic concept along with the discovery of meningeal lymphatic vessels have, in recent years, highlighted that fluid is directionally transported within the central nervous system (CNS). Imaging studies, as well as manipulations of fluid transport, point to a key role of the glymphatic–lymphatic system in clearance of amyloid-β and other proteins. As such, the glymphatic–lymphatic system represents a new target in combating neurodegenerative diseases. Not unexpectedly, introduction of a new plumbing system in the brain has stirred controversies. This opinion article will highlight what we know about the brain's fluid transport systems, where experimental data are lacking, and what is still debated.
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Trends in Neurosciences |
| Vol/bind | 43 |
| Udgave nummer | 7 |
| Sider (fra-til) | 458-466 |
| Antal sider | 9 |
| ISSN | 0166-2236 |
| DOI | |
| Status | Udgivet - 2020 |
Bibliografisk note
Funding Information:
We thank Dan Xue for assistance with the illustrations. This work is supported by the National Institute of Neurological Disorders and Stroke and the National Institute on Aging (US National Institutes of Health: R01NS100366 and RF1AG057575 ), the US Army Research Office (grant number MURI W911NF1910280 to M.N.), Fondation Leducq Transatlantic Networks of Excellence Program, Novo Nordisk and Lundbeck Foundations , and the EU Horizon 2020 research and innovation programme (grant number 666881 ; SVDs@target). The views and conclusions contained in this opinion article are solely those of the authors and should not be interpreted as representing the official policies, either expressed or implied, of the National Institutes of Health, Army Research Office, or the US government. The US government is authorized to reproduce and distribute reprints for government purposes notwithstanding any copyright notation herein.
Publisher Copyright:
© 2020 The Author(s)
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