The brain in acute liver failure. A tortuous path from hyperammonemia to cerebral edema

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Standard

The brain in acute liver failure. A tortuous path from hyperammonemia to cerebral edema. / Bjerring, Peter Nissen; Eefsen, Martin; Hansen, Bent Adel; Larsen, Fin Stolze.

I: Metabolic Brain Disease, Bind 24, Nr. 1, 2008, s. 5-14.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Bjerring, PN, Eefsen, M, Hansen, BA & Larsen, FS 2008, 'The brain in acute liver failure. A tortuous path from hyperammonemia to cerebral edema', Metabolic Brain Disease, bind 24, nr. 1, s. 5-14. https://doi.org/10.1007/s11011-008-9116-3

APA

Bjerring, P. N., Eefsen, M., Hansen, B. A., & Larsen, F. S. (2008). The brain in acute liver failure. A tortuous path from hyperammonemia to cerebral edema. Metabolic Brain Disease, 24(1), 5-14. https://doi.org/10.1007/s11011-008-9116-3

Vancouver

Bjerring PN, Eefsen M, Hansen BA, Larsen FS. The brain in acute liver failure. A tortuous path from hyperammonemia to cerebral edema. Metabolic Brain Disease. 2008;24(1):5-14. https://doi.org/10.1007/s11011-008-9116-3

Author

Bjerring, Peter Nissen ; Eefsen, Martin ; Hansen, Bent Adel ; Larsen, Fin Stolze. / The brain in acute liver failure. A tortuous path from hyperammonemia to cerebral edema. I: Metabolic Brain Disease. 2008 ; Bind 24, Nr. 1. s. 5-14.

Bibtex

@article{427afa006a3911df928f000ea68e967b,
title = "The brain in acute liver failure. A tortuous path from hyperammonemia to cerebral edema",
abstract = "Acute liver failure (ALF) is a condition with an unfavourable prognosis. Multiorgan failure and circulatory collapse are frequent causes of death, but cerebral edema and intracranial hypertension (ICH) are also common complications with a high risk of fatal outcome. The underlying pathogenesis has been extensively studied and although the development of cerebral edema and ICH is of a complex and multifactorial nature, it is well established that ammonia plays a pivotal role. This review will focus on the effects of hyperammonemia on neurotransmission, mitochondrial function, oxidative stress, inflammation and regulation of cerebral blood flow. Finally, potential therapeutic targets and future perspectives are briefly discussed.",
author = "Bjerring, {Peter Nissen} and Martin Eefsen and Hansen, {Bent Adel} and Larsen, {Fin Stolze}",
note = "Keywords: Ammonia; Animals; Brain; Brain Edema; Hepatic Encephalopathy; Humans; Hyperammonemia; Intracranial Hypertension; Liver Failure, Acute; Mitochondria; Oxidative Stress; Water-Electrolyte Balance",
year = "2008",
doi = "10.1007/s11011-008-9116-3",
language = "English",
volume = "24",
pages = "5--14",
journal = "Metabolic Brain Disease",
issn = "0885-7490",
publisher = "Springer",
number = "1",

}

RIS

TY - JOUR

T1 - The brain in acute liver failure. A tortuous path from hyperammonemia to cerebral edema

AU - Bjerring, Peter Nissen

AU - Eefsen, Martin

AU - Hansen, Bent Adel

AU - Larsen, Fin Stolze

N1 - Keywords: Ammonia; Animals; Brain; Brain Edema; Hepatic Encephalopathy; Humans; Hyperammonemia; Intracranial Hypertension; Liver Failure, Acute; Mitochondria; Oxidative Stress; Water-Electrolyte Balance

PY - 2008

Y1 - 2008

N2 - Acute liver failure (ALF) is a condition with an unfavourable prognosis. Multiorgan failure and circulatory collapse are frequent causes of death, but cerebral edema and intracranial hypertension (ICH) are also common complications with a high risk of fatal outcome. The underlying pathogenesis has been extensively studied and although the development of cerebral edema and ICH is of a complex and multifactorial nature, it is well established that ammonia plays a pivotal role. This review will focus on the effects of hyperammonemia on neurotransmission, mitochondrial function, oxidative stress, inflammation and regulation of cerebral blood flow. Finally, potential therapeutic targets and future perspectives are briefly discussed.

AB - Acute liver failure (ALF) is a condition with an unfavourable prognosis. Multiorgan failure and circulatory collapse are frequent causes of death, but cerebral edema and intracranial hypertension (ICH) are also common complications with a high risk of fatal outcome. The underlying pathogenesis has been extensively studied and although the development of cerebral edema and ICH is of a complex and multifactorial nature, it is well established that ammonia plays a pivotal role. This review will focus on the effects of hyperammonemia on neurotransmission, mitochondrial function, oxidative stress, inflammation and regulation of cerebral blood flow. Finally, potential therapeutic targets and future perspectives are briefly discussed.

U2 - 10.1007/s11011-008-9116-3

DO - 10.1007/s11011-008-9116-3

M3 - Journal article

C2 - 19050999

VL - 24

SP - 5

EP - 14

JO - Metabolic Brain Disease

JF - Metabolic Brain Disease

SN - 0885-7490

IS - 1

ER -

ID: 20008910