The basement membrane component laminin in breast carcinomas and axillary lymph node metastases.
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The basement membrane component laminin in breast carcinomas and axillary lymph node metastases. / Nielsen, M; Christensen, L; Albrechtsen, R.
I: Acta pathologica, microbiologica, et immunologica Scandinavica. Section A, Pathology, Bind 91, Nr. 4, 1983, s. 257-64.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - The basement membrane component laminin in breast carcinomas and axillary lymph node metastases.
AU - Nielsen, M
AU - Christensen, L
AU - Albrechtsen, R
N1 - Keywords: Adolescent; Adult; Aged; Axilla; Basement Membrane; Breast Neoplasms; Carcinoma, Intraductal, Noninfiltrating; Female; Glycoproteins; Humans; Immunoenzyme Techniques; Laminin; Lymph Nodes; Lymphatic Metastasis; Middle Aged; Phyllodes Tumor
PY - 1983
Y1 - 1983
N2 - The occurrence of the basement membrane (BM) glycoprotein laminin was investigated in 91 malignant breast tumors and in 359 axillary lymph nodes of which 70 contained metastases. The indirect double-layer immunoperoxidase technique was applied using rabbit anti-rat laminin. Positive cytoplasmic staining for laminin was found in all breast carcinomas. BM could be demonstrated around in situ carcinomas and in the higher differentiated carcinomas around islands of infiltrating tumor cells. Lymph node metastases resembled the primary tumors in the cytoplasmic staining reaction for laminin, but no BM staining was found. Tissue from 50 benign breast lesions showed cytoplasmic staining for laminin in both the secretory and the myoepithelial cells, but consistently weaker than in the carcinomas. BM was always present.
AB - The occurrence of the basement membrane (BM) glycoprotein laminin was investigated in 91 malignant breast tumors and in 359 axillary lymph nodes of which 70 contained metastases. The indirect double-layer immunoperoxidase technique was applied using rabbit anti-rat laminin. Positive cytoplasmic staining for laminin was found in all breast carcinomas. BM could be demonstrated around in situ carcinomas and in the higher differentiated carcinomas around islands of infiltrating tumor cells. Lymph node metastases resembled the primary tumors in the cytoplasmic staining reaction for laminin, but no BM staining was found. Tissue from 50 benign breast lesions showed cytoplasmic staining for laminin in both the secretory and the myoepithelial cells, but consistently weaker than in the carcinomas. BM was always present.
M3 - Journal article
C2 - 6306989
VL - 91
SP - 257
EP - 264
JO - Acta Pathologica Microbiologica et Immunologica Scandinavica - Section A Pathology
JF - Acta Pathologica Microbiologica et Immunologica Scandinavica - Section A Pathology
SN - 0108-0164
IS - 4
ER -
ID: 5237192