The associative brain at work: Evidence from paired associative stimulation studies in humans
Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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The associative brain at work : Evidence from paired associative stimulation studies in humans. / Suppa, A.; Quartarone, A.; Siebner, H.; Chen, R.; Di Lazzaro, V.; Del Giudice, P.; Paulus, Walter; Rothwell, J. C.; Ziemann, U.; Classen, J.
I: Clinical Neurophysiology, Bind 128, Nr. 11, 2017, s. 2140-2164.Publikation: Bidrag til tidsskrift › Review › Forskning › fagfællebedømt
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TY - JOUR
T1 - The associative brain at work
T2 - Evidence from paired associative stimulation studies in humans
AU - Suppa, A.
AU - Quartarone, A.
AU - Siebner, H.
AU - Chen, R.
AU - Di Lazzaro, V.
AU - Del Giudice, P.
AU - Paulus, Walter
AU - Rothwell, J. C.
AU - Ziemann, U.
AU - Classen, J.
PY - 2017
Y1 - 2017
N2 - The original protocol of Paired Associative Stimulation (PAS) in humans implies repetitive cortical and peripheral nerve stimuli, delivered at specific inter-stimulus intervals, able to elicit non-invasively long-term potentiation (LTP)- and long-term depression (LTD)-like plasticity in the human motor cortex. PAS has been designed to drive cortical LTP/LTD according to the Hebbian rule of associative plasticity. Over the last two decades, a growing number of researchers have increasingly used the PAS technique to assess cortical associative plasticity in healthy humans and in patients with movement disorders and other neuropsychiatric diseases. The present review covers the physiology, pharmacology, pathology and motor effects of PAS. Further sections of the review focus on new protocols of “modified PAS” and possible future application of PAS in neuromorphic circuits designed for brain-computer interface.
AB - The original protocol of Paired Associative Stimulation (PAS) in humans implies repetitive cortical and peripheral nerve stimuli, delivered at specific inter-stimulus intervals, able to elicit non-invasively long-term potentiation (LTP)- and long-term depression (LTD)-like plasticity in the human motor cortex. PAS has been designed to drive cortical LTP/LTD according to the Hebbian rule of associative plasticity. Over the last two decades, a growing number of researchers have increasingly used the PAS technique to assess cortical associative plasticity in healthy humans and in patients with movement disorders and other neuropsychiatric diseases. The present review covers the physiology, pharmacology, pathology and motor effects of PAS. Further sections of the review focus on new protocols of “modified PAS” and possible future application of PAS in neuromorphic circuits designed for brain-computer interface.
KW - Paired associative stimulation
KW - Plasticity
KW - Primary motor cortex
KW - STDP
U2 - 10.1016/j.clinph.2017.08.003
DO - 10.1016/j.clinph.2017.08.003
M3 - Review
C2 - 28938144
AN - SCOPUS:85029515782
VL - 128
SP - 2140
EP - 2164
JO - Clinical Neurophysiology
JF - Clinical Neurophysiology
SN - 1388-2457
IS - 11
ER -
ID: 188486957