The Association of MRI Findings and Long-Term Disability in Patients With Chronic Low Back Pain
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The Association of MRI Findings and Long-Term Disability in Patients With Chronic Low Back Pain. / Udby, Peter Muhareb; Ohrt-Nissen, Søren; Bendix, Tom; Brorson, Stig; Carreon, Leah Y; Andersen, Mikkel Østerheden.
I: Global Spine Journal, Bind 11, Nr. 5, 2021, s. 633-639.Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt
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TY - JOUR
T1 - The Association of MRI Findings and Long-Term Disability in Patients With Chronic Low Back Pain
AU - Udby, Peter Muhareb
AU - Ohrt-Nissen, Søren
AU - Bendix, Tom
AU - Brorson, Stig
AU - Carreon, Leah Y
AU - Andersen, Mikkel Østerheden
PY - 2021
Y1 - 2021
N2 - STUDY DESIGN: Longitudinal cohort study with 13-year follow-up.OBJECTIVE: To assess whether long-term disability is associated with baseline degenerative magnetic resonance imaging (MRI) findings in patients with low back pain (LBP).METHODS: In 2004-2005, patients aged 18 to 60 years with chronic LBP were enrolled in a randomized controlled trial and lumbar MRI was performed. Patients completed the Roland-Morris Disability Questionnaire (RMDQ) and the LBP Rating Scale, at baseline and 13 years after the MRI. Multivariate regression analysis was performed with 13-year RMDQ as the dependent variable and baseline disc degeneration (DD, Pfirrmann grade), Modic changes (MC), facet joint degeneration (FJD, Fujiwara grade) smoking status, body mass index, and self-reported weekly physical activity at leisure as independent variables.RESULTS: Of 204 patients with baseline MRI, 170 (83%) were available for follow-up. Of these, 88 had Pfirrmann grade >III (52%), 67 had MC (39%) and 139 had Fujiwara grade >2 (82%) on at least 1 lumbar level. Only MC (β = -0.15, P = .031) and weekly physical activity at leisure (β = -0.51, P < .001) were significantly, negatively, associated with 13-year RMDQ-score (R2 = 0.31).CONCLUSION: DD and FJD were not associated with long-term disability. Baseline MC and weekly physical activity at leisure were statistically significantly associated with less long-term disability.
AB - STUDY DESIGN: Longitudinal cohort study with 13-year follow-up.OBJECTIVE: To assess whether long-term disability is associated with baseline degenerative magnetic resonance imaging (MRI) findings in patients with low back pain (LBP).METHODS: In 2004-2005, patients aged 18 to 60 years with chronic LBP were enrolled in a randomized controlled trial and lumbar MRI was performed. Patients completed the Roland-Morris Disability Questionnaire (RMDQ) and the LBP Rating Scale, at baseline and 13 years after the MRI. Multivariate regression analysis was performed with 13-year RMDQ as the dependent variable and baseline disc degeneration (DD, Pfirrmann grade), Modic changes (MC), facet joint degeneration (FJD, Fujiwara grade) smoking status, body mass index, and self-reported weekly physical activity at leisure as independent variables.RESULTS: Of 204 patients with baseline MRI, 170 (83%) were available for follow-up. Of these, 88 had Pfirrmann grade >III (52%), 67 had MC (39%) and 139 had Fujiwara grade >2 (82%) on at least 1 lumbar level. Only MC (β = -0.15, P = .031) and weekly physical activity at leisure (β = -0.51, P < .001) were significantly, negatively, associated with 13-year RMDQ-score (R2 = 0.31).CONCLUSION: DD and FJD were not associated with long-term disability. Baseline MC and weekly physical activity at leisure were statistically significantly associated with less long-term disability.
U2 - 10.1177/2192568220921391
DO - 10.1177/2192568220921391
M3 - Journal article
C2 - 32875907
VL - 11
SP - 633
EP - 639
JO - Global Spine Journal
JF - Global Spine Journal
SN - 2192-5682
IS - 5
ER -
ID: 260768156