The association of low vitamin k status with mortality in a cohort of 138 hospitalized patients with covid-19

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The association of low vitamin k status with mortality in a cohort of 138 hospitalized patients with covid-19. / Linneberg, Allan; Kampmann, Freja Bach; Israelsen, Simone Bastrup; Andersen, Liv Rabøl; Jørgensen, Henrik Løvendahl; Sandholt, Håkon; Jørgensen, Niklas Rye; Thysen, Sanne Marie; Benfield, Thomas.

I: Nutrients, Bind 13, Nr. 6, 1985, 2021.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › fagfællebedømt

Harvard

Linneberg, A, Kampmann, FB, Israelsen, SB, Andersen, LR, Jørgensen, HL, Sandholt, H, Jørgensen, NR, Thysen, SM & Benfield, T 2021, 'The association of low vitamin k status with mortality in a cohort of 138 hospitalized patients with covid-19', Nutrients, bind 13, nr. 6, 1985. https://doi.org/10.3390/nu13061985

APA

Linneberg, A., Kampmann, F. B., Israelsen, S. B., Andersen, L. R., Jørgensen, H. L., Sandholt, H., Jørgensen, N. R., Thysen, S. M., & Benfield, T. (2021). The association of low vitamin k status with mortality in a cohort of 138 hospitalized patients with covid-19. Nutrients, 13(6), [1985]. https://doi.org/10.3390/nu13061985

Vancouver

Linneberg A, Kampmann FB, Israelsen SB, Andersen LR, Jørgensen HL, Sandholt H o.a. The association of low vitamin k status with mortality in a cohort of 138 hospitalized patients with covid-19. Nutrients. 2021;13(6). 1985. https://doi.org/10.3390/nu13061985

Author

Linneberg, Allan ; Kampmann, Freja Bach ; Israelsen, Simone Bastrup ; Andersen, Liv Rabøl ; Jørgensen, Henrik Løvendahl ; Sandholt, Håkon ; Jørgensen, Niklas Rye ; Thysen, Sanne Marie ; Benfield, Thomas. / The association of low vitamin k status with mortality in a cohort of 138 hospitalized patients with covid-19. I: Nutrients. 2021 ; Bind 13, Nr. 6.

Bibtex

@article{991a6e3dda37470f868035743f453e91,

title = "The association of low vitamin k status with mortality in a cohort of 138 hospitalized patients with covid-19",

abstract = "It has recently been hypothesized that vitamin K could play a role in COVID-19. We aimed to test the hypotheses that low vitamin K status is a common characteristic of patients hospitalized with COVID-19 compared to population controls and that low vitamin K status predicts mortality in COVID-19 patients. In a cohort of 138 COVID-19 patients and 138 population controls, we measured plasma dephosphorylated-uncarboxylated Matrix Gla Protein (dp-ucMGP), which reflects the functional vitamin K status in peripheral tissue. Forty-three patients died within 90 days from admission. In patients, levels of dp-ucMGP differed significantly between survivors (mean 877; 95% CI: 778; 995) and non-survivors (mean 1445; 95% CI: 1148; 1820). Furthermore, levels of dp-ucMGP (pmol/L) were considerably higher in patients (mean 1022; 95% CI: 912; 1151) compared to controls (mean 509; 95% CI: 485; 540). Cox regression survival analysis showed that increasing levels of dp-ucMGP (reflecting low vitamin K status) were associated with higher mortality risk (sex-and age-adjusted hazard ratio per doubling of dp-ucMGP was 1.49, 95% CI: 1.03; 2.24). The association attenuated and became statistically insignificant after adjustment for co-morbidities (sex, age, CVD, diabetes, BMI, and eGFR adjusted hazard ratio per doubling of dp-ucMGP was 1.22, 95% CI: 0.82; 1.80). In conclusion, we found that low vitamin K status was associated with mortality in patients with COVID-19 in sex-and age-adjusted analyses, but not in analyses additionally adjusted for co-morbidities. Randomized clinical trials would be needed to clarify a potential role, if any, of vitamin K in the course of COVID-19.",

keywords = "COVID-19, Elastic fiber, Matrix Gla Protein, SARS-CoV-2, Thrombosis, Vitamin K",

author = "Allan Linneberg and Kampmann, {Freja Bach} and Israelsen, {Simone Bastrup} and Andersen, {Liv Rab{\o}l} and J{\o}rgensen, {Henrik L{\o}vendahl} and H{\aa}kon Sandholt and J{\o}rgensen, {Niklas Rye} and Thysen, {Sanne Marie} and Thomas Benfield",

note = "Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",

year = "2021",

doi = "10.3390/nu13061985",

language = "English",

volume = "13",

journal = "Nutrients",

issn = "2072-6643",

publisher = "M D P I AG",

number = "6",

}

RIS

TY - JOUR

T1 - The association of low vitamin k status with mortality in a cohort of 138 hospitalized patients with covid-19

AU - Linneberg, Allan

AU - Kampmann, Freja Bach

AU - Israelsen, Simone Bastrup

AU - Andersen, Liv Rabøl

AU - Jørgensen, Henrik Løvendahl

AU - Sandholt, Håkon

AU - Jørgensen, Niklas Rye

AU - Thysen, Sanne Marie

AU - Benfield, Thomas

PY - 2021

Y1 - 2021

N2 - It has recently been hypothesized that vitamin K could play a role in COVID-19. We aimed to test the hypotheses that low vitamin K status is a common characteristic of patients hospitalized with COVID-19 compared to population controls and that low vitamin K status predicts mortality in COVID-19 patients. In a cohort of 138 COVID-19 patients and 138 population controls, we measured plasma dephosphorylated-uncarboxylated Matrix Gla Protein (dp-ucMGP), which reflects the functional vitamin K status in peripheral tissue. Forty-three patients died within 90 days from admission. In patients, levels of dp-ucMGP differed significantly between survivors (mean 877; 95% CI: 778; 995) and non-survivors (mean 1445; 95% CI: 1148; 1820). Furthermore, levels of dp-ucMGP (pmol/L) were considerably higher in patients (mean 1022; 95% CI: 912; 1151) compared to controls (mean 509; 95% CI: 485; 540). Cox regression survival analysis showed that increasing levels of dp-ucMGP (reflecting low vitamin K status) were associated with higher mortality risk (sex-and age-adjusted hazard ratio per doubling of dp-ucMGP was 1.49, 95% CI: 1.03; 2.24). The association attenuated and became statistically insignificant after adjustment for co-morbidities (sex, age, CVD, diabetes, BMI, and eGFR adjusted hazard ratio per doubling of dp-ucMGP was 1.22, 95% CI: 0.82; 1.80). In conclusion, we found that low vitamin K status was associated with mortality in patients with COVID-19 in sex-and age-adjusted analyses, but not in analyses additionally adjusted for co-morbidities. Randomized clinical trials would be needed to clarify a potential role, if any, of vitamin K in the course of COVID-19.

AB - It has recently been hypothesized that vitamin K could play a role in COVID-19. We aimed to test the hypotheses that low vitamin K status is a common characteristic of patients hospitalized with COVID-19 compared to population controls and that low vitamin K status predicts mortality in COVID-19 patients. In a cohort of 138 COVID-19 patients and 138 population controls, we measured plasma dephosphorylated-uncarboxylated Matrix Gla Protein (dp-ucMGP), which reflects the functional vitamin K status in peripheral tissue. Forty-three patients died within 90 days from admission. In patients, levels of dp-ucMGP differed significantly between survivors (mean 877; 95% CI: 778; 995) and non-survivors (mean 1445; 95% CI: 1148; 1820). Furthermore, levels of dp-ucMGP (pmol/L) were considerably higher in patients (mean 1022; 95% CI: 912; 1151) compared to controls (mean 509; 95% CI: 485; 540). Cox regression survival analysis showed that increasing levels of dp-ucMGP (reflecting low vitamin K status) were associated with higher mortality risk (sex-and age-adjusted hazard ratio per doubling of dp-ucMGP was 1.49, 95% CI: 1.03; 2.24). The association attenuated and became statistically insignificant after adjustment for co-morbidities (sex, age, CVD, diabetes, BMI, and eGFR adjusted hazard ratio per doubling of dp-ucMGP was 1.22, 95% CI: 0.82; 1.80). In conclusion, we found that low vitamin K status was associated with mortality in patients with COVID-19 in sex-and age-adjusted analyses, but not in analyses additionally adjusted for co-morbidities. Randomized clinical trials would be needed to clarify a potential role, if any, of vitamin K in the course of COVID-19.

KW - COVID-19

KW - Elastic fiber

KW - Matrix Gla Protein

KW - SARS-CoV-2

KW - Thrombosis

KW - Vitamin K

U2 - 10.3390/nu13061985

DO - 10.3390/nu13061985

M3 - Journal article

C2 - 34207745

AN - SCOPUS:85107446940

VL - 13

JO - Nutrients

JF - Nutrients

SN - 2072-6643

IS - 6

M1 - 1985

ER -

ID: 272174676